Biological activity structure

Cramer, R.D., Poss, M.A., Hermsmeier, M.A., Caulfield, T.J., and Kowala, M.C. Prospective identification of biologically active structures by topomer shape similarity searching. /. Med. Chem. 

The related elements, proton hydrogen (H ), and hydride (H ) change their physical properties (including their size) drastically by the change of the number of electrons. Hydrogen-bond and proton-transfer interactions are the key to understanding many chemical reactions, biological activities, structure of molecular assemblies and supramolecules, functionalities in the solid state, etc. 

Chemical modification of the biomaterial with photoisomerizable units represents one approach to controlling intermolecular affinity interactions (Scheme 2(A)). In one photoisomer state of the biomaterial, its tertiary, biologically active structure is retained and the formation of the intermolecular complex is facilitated. In the complementary photoisomer state, the bioactive binding site is distorted and the formation of the intermolecular recognition complex is switched off. The bind-... 

Oxidizing polymers and polymer-supported carbanion equivalents, in particular, have been employed successfully for preparation of protease inhibitor collections as a practically relevant example. With peptide aldehydes and differently substituted a-hydroxy-jS-amino carbonyl moieties two inhibitory motifs have been prepared with hitherto unprecedented ease and efficiency. Now it remains to be demonstrated that the synthetic methodology as introduced here is capable of assisting the identification of novel biologically active structures. 

Discussion of the field of conformational analysis and protein folding is beyond the scope of this section. Nevertheless, the concept that the most potent drugs mimic the three-dimensional ( biologically active ) structure of the native peptide bound to its receptor became an important driving force in the field of peptide chemistry. The stabilization of this structure would result in increased potency and more efficacious pharmaceuticals. 

After duVigneaud s proof of the biologically active structure of oxytocin by total synthesis... 

Soil indicators organic matter, biological activity, structure and erosion... 

Botrytis species an intriguing source of metabolites with a wide range of biological activities. Structure, chemistry and bioactivity of metabolites isolated from Botrytis species. LG. Collado, J. Aleu, R. Hernandez-Galan and R. Duran-Patron, Curr. Org. Chem., 2000, 4, 1261. 

F. Micropatterning of Biologically Active Structures with the SECM... 

The iterative deconvolution procedure has been applied successfully to determine the biologically active structure directly, but several issues should be considered. Firstly, as... 

Unsaturated 8-lactones are biologically active structural elements in many natural products. The synthesis of this heterocyclic moiety can be achieved by a Knoevenagel condensation of 3-hydroxy aldehydes with active methylene in the presence of TiCU/pyridine or under standard conditions. ° " ... 

By now an immobihzation on diamond films succeeded for several biologically active structures like DNA-fragments, oligonucleotides, peptides, enzymes, etc. AH of them were proven to retain their activity also in the bound state by showing their respective interaction in suitable test systems. Apart from biological moieties, also catalysts or other reagents may be connected to diamond films. Many studies... 

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