Streptoverticillium

MacroHdes are obtained by controUed submerged aerobic fermentations of soil microorganisms. Although species of Streptomjces have dominated, species of Saccharopoljspora Micromonospora and Streptoverticillium are also weU represented. New techniques such as enzyme-linked immunosorbent assay (ELISA) based assays may prove beneficial for discovering new stmctures (464). 

A.ctinomadura macra 2SXQQ 31286 A.ctinomadura macra 2SXQQ 31286 Streptomyces sp. ATCC 53862 A.ctinomadura sp. ATCC 53764 Streptoverticillium eurocidicum SANK 61484... 

Streptoverticillium eurocidium ATCC 31175, Streptomyces olivoreticuli A14939... 

The full structure and absolute configuration of FR 900848 104 has been determined to be (6R,8S,9R,11S,12S,14R,15S,17R) from X-ray crystallographic study [133]. Strategies for its enantioselective total synthesis are based on an iterative cyclopropanation [134], and on the use of chiral auxiliaries [135]. It has also been prepared by fermentation and isolated from cultures of Streptoverticillium fervens to be considered as an agrochemical microbicide [136]. 

Streptoverticillium album K-25l/ the antitumoral bis-indole alkaloids vinblastine and vincristine/ verruculogen, a very potent mycotoxin produced by several Penicillium species and melatonin, a hormone found in all living creatures from algae to humans, just to mention the most important ones. 

Matsuda Y, Asano K, Kawamoto I, YasuzawaT, Shirahata K, Sano H, Kase H, K-251 compounds, inhibitors of Ca and cahnodulin-. dependent cyclic nucleotide phosphodiesterase from Streptoverticillium album, Agric Biol Chem 52 3211-3213, 1988. 

In 1988, Nakamura et al. reported the isolation of carbazomycins G (269) and H (270) from the culture broth of Streptoverticillium ehimense. These alkaloids have a structurally unique carbazole-l,4-quinol framework and were obtained from Nature in racemic form. Carbazomycin G showed moderate antifungal activity against... 

In 1991, Kojiri et al. reported the isolation of BE-13793C (344), an alkaloid isomeric with the arcyriaflavins C (347) and D (348) (see Scheme 2.89), from the culture broth of Streptoverticillium moharaense strain BA 13793 collected in Seto, Aichi Perfecture, Japan. BE-13793C (344) showed strong inhibitory activity against topoisomerases I and II and inhibited the growth of doxorubicin-resistant or vincristine-resistant P-388 murine leukemia cell lines, as well as their parent P-388 cell line (330). 

The bacterial oxazoles span a wide range in structural complexity. The most simple are the indolyl compounds pimprinine (70), pimprinethine (71), and pimprinaphine (72). All three compounds, which are colorless and crystalline, cooccur in Streptoverticillium olivoreticuli (28), with pimprinine (70) having... 

Application and Principle This procedure is used to determine transglutaminase activity in preparations derived from Streptoverticillium mobaraense var. The assay is based on the enzymatic formation of a glutamic acid y-hydroxamate in a glutaminyl residue in the substrate peptide with another substrate, hydroxylamine. The amount of the glutamic acid y-hydroxamate formed as a red complex with ferric ion in acidic conditions at 37° is measured spectrophotometrically. 

Carbazomycin G and H have been isolated from Streptoverticillium ehimense [38]. In nature carbazomycin G occurs as a racemic mixture and the same is assumed for carbazomycin H. Garbazomycin G was reported to show antifungal activity. The two compounds share a unique structure, namely the carbazole-l,4-quinol moiety. Starting from the appropriate iron complex salt, iron-mediated arylamine cydization provides a simple route to both alkaloids (Scheme 15.10) [39]. 

A new carbazole alkaloid, streptoverticillin, has been isolated from Streptoverticillium morookaense, and has been shown to exhibit antifungal activity against Peronophythora litchii <2007JAN179>. 

The leucomycin complex is comprised of ten factors which differ in the number and type of short-chain acyl substituents on the 3- and 4"-hydroxyl groups [1-3], In the generalized structure depicted in Figure 5.2, R is acetyl or hydrogen, and R is 3-methylbutanoyl (isovaleryl, iVal), n-butyryl, propionyl, acetyl, or hydrogen. The leucomycin complex (also called kitasamycin) was isolated from culture broths of Streptomyces kitasatoensis [18], an organism later reclassified into the genus Streptoverticillium [19]. 

Mannostatin A, a pentasubsthuted amino-cyclopentane produced by Streptoverticillium verticillus var quintum ME3-AG3 [113], is also a specific inhibitor of a-D-mannosidase and has shown anti-metastatic activity [114],... 

Perhaps ASTM E1428 (a. 16), commonly referred to as the Pink Stain test, is one of the most recognised plastic test methods. The actinomycete Streptoverticillium reticulum is used as an indicator organism to inoculate yeast malt extract agar. Test discs of plastic are placed on the surface and incubated at 29 °C for three weeks. Assessment focuses on the extent of staining of the... 

This pigment is a prodigiosin-like pigment, actually a mixture of two prodiginines (a. 17) but is not exclusive to Streptoverticillium sp. 

Absence of staining indicates the effectiveness of the biostabiliser when compared to a control plastic. Streptoverticillium waksmanii produces a similar effect. 

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