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Doxorubicin resistance

S9788. Comparison with 11 other MDR-modulating agents in a model of doxorubicin-resistant rat glioblastoma cells, Eur. J. Cancer 1993, 30, 1377-1383. [Pg.493]

Wang K, Ramji S, Bhathena A et al. Glutathione S-transferases in wild-type and doxorubicin-resistant MCF-7 human breast cancer cell lines. Xenobiotica 1999 ... [Pg.308]

Bellamy, W.T., Dalton, W.S., Kailey, J.M., Gleason, M.C., McCloskey, T.M., Dorr, R. T. and Alberts, D.S. (1988) Verapamil reversal of doxorubicin resistance in multidrug-resistant human myeloma... [Pg.362]

Allen, J. D., Jackson, S. C., and Schinkel, A. H. (2002) A mutation hot spot in the BCRPl (ABCG2) multidrug transporter in mouse cell fines selected for doxorubicin resistance. Cancer Res. 62, 2294-2299. [Pg.59]

Ahmad S, Glazer RI (1993) Expression of the antisense cDNA for protein kinase C alpha attenuates resistance in doxorubicin-resistant MCF-7 breast carcinoma cells. Mol Pharmacol 43 858-862... [Pg.61]

Ahn CH, Kong JY, Choi WC, Wang MS (1996) Selective inhibition of the effects of phorbol ester on doxorubicin resistance and P-glycoprotein by the protein kinase C inhibitor l-(5-isoquinolinesulfonyl)-2-methylpipera2inc (H7) in multidrug-resistant MCF-7/Dox human breast carcinoma cells. Biochem Pharmacol 52 393-399... [Pg.61]

In 1991, Kojiri et al. reported the isolation of BE-13793C (344), an alkaloid isomeric with the arcyriaflavins C (347) and D (348) (see Scheme 2.89), from the culture broth of Streptoverticillium moharaense strain BA 13793 collected in Seto, Aichi Perfecture, Japan. BE-13793C (344) showed strong inhibitory activity against topoisomerases I and II and inhibited the growth of doxorubicin-resistant or vincristine-resistant P-388 murine leukemia cell lines, as well as their parent P-388 cell line (330). [Pg.139]

BSA Doxorubicin Alkylamine bond between drug aminoribosyl and glutaraldehyde spacer None N/A Showed marked anticancer activity against doxorubicin resistant AH66DR cells N/T 51... [Pg.67]

Booser, D. J., Esteva, F. J., Rivera, E., Valero, V., Esparza, G., Priebe, W., and Hortobagyi, G. (2002). Phase II study of liposomal annamycin in the treatment of doxorubicin-resistant breast Gaamsr Chemother. Pharmacol., 50, 6-8. [Pg.409]

Vaclavikova et al. [216] have investigated the effect of 13 flavonoid derivatives—aurones, chalcones, flavones, flavonols, chromones, and isoflavones—on 14 C-paclitaxel transport in two human breast cancer cell lines, the doxorubicin-resistant NCI/ADR-RES and sensitive MDA-MB-435. The compounds with known binding affinity toward the NBD of P-gp were selected. The four aurones studied most effectively inhibited P-gp-related transport in the resistant fine in comparison with other groups of flavonoids. The aurones also most effectively increased the intracellular accumulation of paclitaxel and decreased its efflux. The results obtained did not always correlate with the binding of flavonoid derivatives to P-gp, so this indicated that the binding was not the only factor influencing the transport of paclitaxel. The different aspects of inhibition of P-gp by polyphenols was recently reviewed by Kitagawa [212],... [Pg.274]

Conrad S, Kauffmann HM, Ito K, Leslie EM, Deeley RG, Schrenk D, Cole SPC. A naturally occurring mutation in MRP1 results in a selective decrease in organic anion transport and in increased doxorubicin resistance. Pharmacogenetics 2002 12 321-330. [Pg.149]

Kudoh K, Ramanna M, Ravatn R, Elkahloun AG, Bittner ML, Meltzer PS, Trent JM, Dalton WS, Chin KV. Monitoring the expression profiles of doxorubicin-induced and doxorubicin-resistant cancer cells by cDNA microarray. Cancer Res 2000 60 4161 4166. [Pg.409]

Much earlier, the partitioning of [14C]-doxorubicin was determined in subcellular fractions of doxorubicin-sensitive (V-79) and doxorubicin-resistant (LZ) hamster lung fibroblast cell lines. A significant difference was reported (Table 5.14) [114], At concentrations clinically relevant in vivo, doxorubicin preferentially partitioned into the membrane, achieving a 100-fold higher concentration in the membrane fraction than the cytosol fraction. The data in Table 5.14 show the ability of resistant cells to decrease the doxorubicin content in the lipid fraction of the membrane. It is remarkable that the doxorubicin content of the lipid membrane fraction in resistant cells decreased about ninefold, whereas the reduction in whole cells is only fourfold in com-... [Pg.260]

Table 5 The effects of carotenoids on MDR reversal in doxorubicin-resistant MCF7/KCR MDRl-expressing human breast cancer cell line... Table 5 The effects of carotenoids on MDR reversal in doxorubicin-resistant MCF7/KCR MDRl-expressing human breast cancer cell line...
Vanhoefer U, Cao S, Minderman H, Toth K, Scheper RJ, Slovak ML, Rustum YM (1996) PAK-104P, a pyridine analogue, reverses paclitaxel and doxorubicin resistance in cell lines and nude mice bearing xenografts that overexpress the multidrug resistance protein. Clin Cancer Res 2 369-377... [Pg.250]

Investigation of doxorubicin resistance in MCF-7 breast cancer cells using shot-gun comparative proteomics with proteolytic 180 labeling. J. Proteome Res. 3, 455 62. [Pg.82]

Le Cesne A, Vassal G, Far ace F, Spielmann M, Le Chevalier T, Angevin E et al. Combination interleukin-2 and doxorubicin in advanced adult solid tumors Circumvention of doxorubicin resistance in soft-tissue sarcoma J Immunother 1999 22 268-77. [Pg.499]

Withoff, S., Keith, W., Knol, A., Coutts, J., Hoare, S., Mulder, N., and de Vries, E. (1996) Selection of a subpopulation with fewer DNA topoisomerase II alpha gene copies in a doxorubicin-resistant cell line panel. Br. J. Cancer 74,502-507. [Pg.222]

Doxorubicin-resistant tumors Eungal infections Lymphomatous meningitis Metastatic malignant uveal melanoma Ovarian cancer Advanced cancer Various tumors Advanced cancer... [Pg.4]

Booser DJ et al (2002) Phase 11 study of liposomal annamycin in the treatment of doxorubicin-resistant breast cancer. Cancer Chemother Pharmacol 50 6-8... [Pg.22]

Miraglia, E. Viarisio, D. Riganti, C. Costamagna, C. Ghigo, D. Bosia, A. NaVH+ exchanger activity is increased in doxorubicin-resistant human colon cancer ceUs and its modulation modifies the sensitivity of the cells to doxorubicin. Int. J. Cancer 2005, 115, 924-929. [Pg.214]

Thierry, A. R., Vige, D., Coughhn, S. S., Belh, J. A., Dritscilo, A., Rahman, A. Modulation of doxorubicin resistance in multi-drug resistant cells by liposomes. FASEB J. 1993, 7, 572—579. [Pg.812]

Ji BS, Fie L, Liu GQ. Reversal of p-glycoprotein-mediafed multidrug resistance by CJXl, an amlodipine derivative, in doxorubicin-resistant human myelogenous leukemia (K562/... [Pg.88]

See other pages where Doxorubicin resistance is mentioned: [Pg.300]    [Pg.327]    [Pg.216]    [Pg.78]    [Pg.78]    [Pg.80]    [Pg.81]    [Pg.111]    [Pg.404]    [Pg.251]    [Pg.279]    [Pg.527]    [Pg.174]    [Pg.1192]    [Pg.1192]    [Pg.168]    [Pg.487]    [Pg.394]    [Pg.208]    [Pg.111]    [Pg.356]    [Pg.49]    [Pg.484]    [Pg.37]    [Pg.38]    [Pg.56]   
See also in sourсe #XX -- [ Pg.251 ]



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