Streptomyces fradiae

Streptomyces capreolus Capreomycin sulfate Streptomyces davuHgerus Clavulanic acid Streptomyces distallicus Stallimycin HCl Streptomyces erythreus Erythromycin Streptomyces fradiae Neomycin... [Pg.1608]

More frequently, however, mutation is used to block a particular pathway. Streptomyces fradiae produces neomycin. 2-Deoxystreptamine is an intermediate in the biosynthetic pathway leading to the production of neomycin (see Figure 6.20). [Pg.182]

Neomycin Streptomyces fradiae Broad spectrum Protein synthesis... [Pg.268]

From fermentation solutions of Streptomyces fradiae (ATCC 21096). [Pg.936]

Streptomyces flocculus Streptomyces fradiae Streptomyces griseus... [Pg.212]

Miao, V., Brost, R., Chappie, J. et al. (2006) The lipopeptide antibiotic A54145 biosynthetic gene cluster from Streptomyces fradiae. Journal of Industrial Microbiology Biotechnology, 33, 129. [Pg.259]

The last paper in this category describes monitoring of a submerged filamentous bacterial cultivation.38 Arnold et al. studied a 12-1 stirred tank where a strain of Streptomyces fradiae was used for fermentation. They followed ammonium, methyl oleate, glucose, and glutamate concentrations over time in the production of tylosin. [Pg.392]

H Bacteria -Streptomyces fradiae Actinomycin Z5 - peptide antibiotic 242... [Pg.52]

TABLE 2.8. Proteins Encoded in the Genomic Area Covering the neo-Cluster of Streptomyces fradiae DSM 40063 (Accession Code AJ629247) ... [Pg.42]

Neomycin Neomycin is a complex of aminoglycoside antibiotics (neomycin A, neomycin B, and neomycin C) that is synthesized by the actinomycete Streptomyces fradiae. [26-30]. For example, neomycin B is 0-2,6-diamino-2,6-didesoxy-a-D-glucopyranosyl-(l )-0-[0-2,6-diamino-2,6-didesoxy-)3-L-idopyranosyl(l—>3)-)3-D-ribofuranosyl-(l— 5)]-2-desoxy-D-streptamine (20.3.1). [Pg.275]

Of the eight aminoglycosides that are currently used, five are synthesized from different versions of Streptomyces streptomycin (isolated from Streptomyces griseus), neomycin (isolated from Streptomyces fradiae), paromomycin (isolated from S. rimosus), kanamycin (isolated from Streptomyces kanamyceticus), and tobramycin (isolated from... [Pg.475]

Streptomyces fradiae (Waksman and Curtis 1916) Waksman and Henrici 1948, Actinmn., Bact. [Pg.141]

It is isolated from Streptomyces fradiae and is effective against most gram negative bacilli and some gram positive cocci. Because of its high ototoxicity and nephrotoxicity, it is not used systemically and used locally in various skin and eye infections. [Pg.329]

Tylosin (tylosin A) is a macrolide antibiotic produced by Streptomyces fradiae. Desmycosin (tylosin B), macrocin (tylosin C), and relomycin (tylosin D) are minor compounds also produced by this bacterial strain. [Pg.63]

Lackner H, Bahner I, Shigematsu N, Pannell LK, Mauger AB (2000) Structures of Five Components of the Actinomycin Z Complex from Streptomyces fradiae, Two of Which Contain 4-Chlorothreonine. J Nat Prod 63 352... [Pg.431]

Tylosin (Figure 3.64) is an important veterinary antibiotic. It is produced by Streptomyces fradiae, and is used to control chronic respiratory diseases caused by Mycoplasma galliseptum in poultry, and to treat Gram-positive infections in pigs. [Pg.100]

S. L. Ward, Z. Hu, A. Schirmer, R. Reid, W. P. Revill, C. D. Reeves, O. V. Petrakovsky, S. D. Dong, and L. Katz, Chalcomycin biosynthesis gene cluster from Streptomyces bikiniensis Novel features of an unusual ketolide produced through expression of the chm polyketide synthase in Streptomyces fradiae, Antimicrob. Agents Chemother., 48 (2004) 4703-4712 and references therein. [Pg.213]

The first of these compounds to be used in animal medicines, Tylosin, was isolated from Streptomyces fradiae. Its chemical structure which is typical of this group of compounds, is based on a lactone ring to which carbohydrate... [Pg.121]

Butler AR, Bate N, Kiehl DE et al (2002) Genetic engineering of aminodeoxyhexose biosynthesis in Streptomyces fradiae. Nat Biotechnol 20 713-716... [Pg.143]

Bauer NJ, Kreuzman AJ, Dotzlaf JE et al (1988) Purification, characterization, and kinetic mechanism of S-adenosyl-L- methionine macrocin O-methyltransferase from Streptomyces fradiae. J Biol Chem 263 15619-15625... [Pg.147]

Direct Fermentative Production of Acyltylosins by Genetically Engineered Strains of Streptomyces fradiae... [Pg.89]

Table 2 Productivity of Acyltylosins by Streptomyces fradiae (pABl 1AEH)...

A Arisawa, N Kawamura, T Narita, I Kojima, K Okamura, H Tsunekawa, T Yoshioka, R Okamoto. Direct fermentative production of acyltylosins by genetically-engineered strains of Streptomyces fradiae. J Antibiot 49 451-456, 1996. [Pg.109]

N Bate, AR Butler, AR Gandecha, E Cundliffe. Multiple regulatory genes in the tylosin biosynthetic cluster of Streptomyces fradiae. Chem Biol 6 617-624, 1999. [Pg.109]

L Tang, Y-X Zhang, CR Hutchinson. Amino acid catabolism and antibiotic synthesis valine is a source of precursors for macrolide biosynthesis in Streptomyces ambo-faciens and Streptomyces fradiae. J Bacteriol 176 6107-6119, 1994. [Pg.110]

SA Fish, E Cundliffe. Stimulation of polyketide metabolism in Streptomyces fradiae by tylosin and its glycosylated precursors. Microbiology 143 3871-3876, 1997. [Pg.111]

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