Streptomyces erythreus

The broth is placed in an iron tank of 350 gallon capacity and is sterilized by heating it under pressure at a temperature of about 120°C for 30 minutes. The sterilized broth is cooled and inoculated aseptically with spores oi Streptomyces erythreus, NRRL 2338. 

Streptomyces capreolus Capreomycin sulfate Streptomyces davuHgerus Clavulanic acid Streptomyces distallicus Stallimycin HCl Streptomyces erythreus Erythromycin Streptomyces fradiae Neomycin... 

The fungus Streptomyces erythreus is the source of a number of structurally related macrolide antibiotics that are collectively known as the erythromycins. The erythromycins occupy a prominent position in medicine by virtue of their useful antibacterial properties. Their use in therapy over the course of the last three decades has been widespread, and has resulted in the saving of many human lives. In this chapter, we address the landmark total synthesis of erythronolide B (1), the biosynthetic precursor of all the erythromycins, by E.J. Corey and his coworkers which was carried out at Harvard in the 1970s.1... 

Erythromycin Streptomyces erythreus Gram-positive bacteria Protein synthesis... 

From fermentation solutions of Streptomyces erythreus. Reference(s) ... 

Deoxyerythronolide B (28), produced by blocked mutants of Streptomyces erythreus, is a common biosynthetic precursor leading to erythromycins. A different route to this compound was developed with aldol methodology.5 In this approach, all the crucial C C bond formations involved in the construction of the carbon framework are exclusively aldol reactions. 

Streptomyces caelestis antibiotic resistant, 3 35 Streptomyces erythreus... 

Polycyclic endriandric acid A-like Endiandra introrsa C.T. White, Lauraceae, Ang. from Australian foests MI). Macrolides ervthromvcin-like erythromycin Streptomyces erythreus, Actinom., Bact. from the Philippine soil and picromycins, from temperate soil MI). 

Erythromycin was the first macrocyclic antibiotic which was isolated from Streptomyces erythreus. Erythromycin is widely used antibiotic both in children as well as in adults. 

The macrolides are a group of closely related compounds characterized by a macrocyclic lactone ring (usually containing 14 or 16 atoms) to which deoxy sugars are attached. The prototype drug, erythromycin, which consists of two sugar moieties attached to a 14-atom lactone ring, was obtained in 1952 from Streptomyces erythreus. Clarithromycin and azithromycin are semisynthetic derivatives of erythromycin. 

Erythromycin is a macrolide antibiotic produced by Streptomyces erythreus. It is considered the most active macrolide for treatment of staphylococcal infections in cases of penicillin resistance. It is used parenterally at a dosage of 3-5 mg/kg bw, in intramammary form at 300 mg/quarter, and orally at 20-50 mg/kg bw. For treatment of mycoplasmal infections in poultry, an oral medication... 

Erythromycins from Streptomyces erythreus strains are probably the structurally most complex of the best selling drugs. Erythromycin A costs only about 5 DM per gram. The two principal erythromycins A and B differ only with respect to hydroxylation at C-12. 

The erythromycins (Figure 3.65) are macrolide antibiotics produced by cultures of Saccharopolyspora erythraea (formerly Streptomyces erythreus). The commercial product... 

It is noteworthy that deosamines structurally related to amosamine (XXXIX) had previously been found in fermentation liquors of Streptomyces erythreus, but not as constituents of nucleosides. For example, a 3,4,6-trideoxy-3-dimethylamino-aldo-... 

The O-methyl group of L-cladinose (2) is also derived from L-methionine. The O-methylation step does not, however, take place at the level of the nucleotide-sugar, but it occurs when the substrate is erythromycin C, which contains L-mycarose and D-desosamine as glycosidic components9 (see Scheme la). The O-methylation of the L-mycarose moiety of erythromycin C by a partially purified enzyme from Streptomyces erythreus was described by Alpine and Corcoran.10,11 The reaction catalyzed is shown in Scheme la. 

An antimicrobial substance produced by the growth of certain strains of Streptomyces erythreus. It is a mixture consisting largely of erythromycin A with lesser amounts of erythromycins B and C. 

Straphanthuis grains, 834 Strepsils, 353 Streptocidum, 991 Streptomyces ambofaciens, 973 Streptomyces anUhwUcus, 832 Streptomyces erythreus, 589 Streptomyces fradiae, 802, 1058 Streptomyces garyphalus, 504 Streptomyces griseus, 976 Streptomyces kanamyceticus, 693 Streptomyces mediterra net, 960 Streptomyces natalensis, 801... 

CAS 114-07-8. C37H67NOB. An antibiotic produced by growth of Streptomyces erythreus Waksman. It is effective against infections caused by Gram-positive bacteria, including some 3-hemolytic streptococci, pneumococci, and staphylococci. 

The best known example of this class of compounds is erythromycin—a metabolite produced by the microorganism Streptomyces erythreus. The structure (Fig. 10.73) consists of a macrocylic lactone ring with a sugar and an aminosugar attached. The sugar residues are important for activity. 

Erythromycins. Erythromycin A (14, R = OH, R = CH3, R" = H), the most widely used macrolide antibiotic, was the principal product found in culture broths of Streptomyces erythreus (39), now reclassified as Saccharopolyspora eythraea (40). It contains a highly substituted aglycone, erythronolide A, (16, R = R = OH) to which desosamine (1, R = OH, R = H) and dadinose (8, R = CH3) are attached (41). The complete stereochemistry of erythromycin A was established by x-ray analysis of its hydroiodide dihydrate (42) total synthesis of erythromycin A was a landmark achievement (43), a task previously considered hopeless (44). 

Stanzak, R., Matsushima, P., Baltz, R.H. Rao, R.N. Cloning and expression in Streptomyces lividans of clustered erythromycin biosynthesis genes from Streptomyces erythreus. Biotechnol. 4, 229-232 (1986). 

Shafiee, A. Hutchinson, C. R. Macrolide antibiotic biosynthesis isolation and properties of two forms of 6-deoxyerythronolide B hydroxylase from Saccharopolyspora erythraea (Streptomyces erythreus). Biochemistry 26, 6204-6210 (1987). 

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