Streptomyces distallicus

A spore suspension obtained upon washing a culture oi Streptomyces distallicus is added to 3,000 ml of a sterile medium consisting of the following ... 

Streptomyces capreolus Capreomycin sulfate Streptomyces davuHgerus Clavulanic acid Streptomyces distallicus Stallimycin HCl Streptomyces erythreus Erythromycin Streptomyces fradiae Neomycin... 

Streptomyces distallicus the structure elucidation and synthesis have also been made by them.165 A wide variety of porphyrins which are derivatives of porphin (125 R = H) occur in nature and exert three biological functions (a) oxygen storage and transport, as in hemoglobin, (b) cellular respiration as in the cytochromes, and (c) photosynthesis, as in the chlorophylls for detailed discussion of structures and synthesis of naturally occurring porphyrins, see references.166 Recent developments in the chemistry of polypyrrolic compounds have been reviewed.167 Several naturally occurring indole alkaloids have dimeric structures of type B,168 an example of which is c-toxiferine-I, a calabash curare alkaloid found in South American species of Strychnos.169... 

Distamycin A (309) is an oligopeptide, isolated from Streptomyces distallicus that inhibits transcription and replication of DNA viruses along with its other related semisynthetic analogs [18]. Example of DNA viruses inhibited by this group are vaccinia virus and HSV-1. Distamycin A also shows inhibitory activity for RT of retroviruses [18]. 

Distamycins. Pyrrole antibiotics from Streptomyces distallicus, used topically to treat herpes simplex infections, e.g., D.A (stallimycin) C22H27N,04, Mr 481.51, mp. 154-156 °C used as the hydrochloride... 

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