Bacterium Streptomyces fradiae

Neomycin, produced by the bacterium Streptomyces fradiae, is an aminoglycoside antibiotic that shows good activity against gramnegative bacteria and some gram-positives. Neomycin is made up of neomycin B and neomycin C. Hydrolysis of neomysin B yields neamine made up of neosamine B and the amino-cyclitol, 2-deoxystreptamine, and the disaccharide neobiosamine B composed of o-ribose and neosamine B. Hydrolysis of neomycin C produces neamine and neobiosamine C, a disaccharide... 

In addition, note that antibiotic preparations themselves are often contaminated with DNA encoding antibiotic-resistant genes. Fluorescence spectroscopy and PCR amplification have shown that a number of antibiotic preparations are contaminated with significant amounts of DNA from the antibiotic-producing bacterium (for example, the gene ermSF of Streptomyces fradiae, which is responsible for resistance to MLS antibiotics) [115]. 

Further examples of BVMO reactions are reported in the biosynthesis of urdamycin (the antitumor antibiotic produced by the soil bacteria Streptomyces fradiae TU 2717) [38], jadomycin (a glycoside antibiotic produced by the soil bacterium Streptomyces venezuelae ISP5230) [39], and 5-alkenyl-3,3(2//)-furanones (isolated from Streptomyces aculeolatus NRRL 18422 and Streptomyces sp. Eco86) [40],... 

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