Streptococcus pneumoniae Pneumococcal vaccine

Xu, J., Dai, W., Wang, Z., Chen, B., Li, Z., and Fan, X. (2011). Intranasal vaccination with chitosan-DNA nanoparticles expressing pneumococcal surface antigen a protects mice against nasopharyngeal colonization by streptococcus pneumonia, Clin. Vaccine Immunol., 18(1), 75-81. 

Hilleman MR, Carlson AJ, McLean AA, Vella PP, Weibel RE, Woodhour AF. Streptococcus pneumoniae polysaccharide vaccine age and dose responses, safety, persistence of antibody, revaccination, and simultaneous administration of pneumococcal and influenza vaccines. Rev Infect Dis 1981 3(suppl) S31-S42. 

Immunization against pneumococcal pneumonia and bacteremia caused by the types of pneumococci included in the vaccine Active immunization against Streptococcus pneumoniae for infants and toddlers... 

Herd immunity refers to high levels of immunization in one population resulting in protection of another unvaccinated population. For example, concentrated vaccination of children with the 7-valent pneumococcal conjugate vaccine resulted in decreased invasive Streptococcus pneumoniae infection not only in the vaccinated children, but also in elderly persons within the same community. 

Streptococcus pneumoniae is the most common bacterial cause of community-acquired respiratory tract infections. S. pneumoniae causes approximately 3000 cases of meningitis, 50,000 cases of bacteremia, 500,000 cases of pneumonia, and over 1 million cases of otitis media each year. The increasing prevalence of drug-resistant S. pneumoniae has highlighted the need to prevent infection through vaccination. Both licensed pneumococcal vaccines are highly effective in preventing disease from the common S. pneumoniae serotypes that cause human disease. 

Pneumococcal vaccine is a mixture of capsular polysaccharides from 23 of the 83 most prevalent types of Streptococcus pneumoniae seen in the United States. 

Pneumococcal Disease In October 2002, the FDA approved the use of Prevnar for immunization of infants and toddlers against otitis media— middle ear infection. Prevnar is a pneumococcal seven-valent conjugate vaccine. It is formulated with a sterile solution of saccharides conjugated to the antigen, Streptococcus pneumoniae. 

Pneumococcal vaccines Mixture of purified surface polysaccharide antigens obtained from differing serotypes of Streptococcus pneumoniae Active immunization against Streptococcus pneumoniae... 

Pneumococcal vaccine, polyvalent [FDA former] Streptococcus pneumonia capsular polysaccharide vaccine [SY]... 

Wang, Q., Wang, M., Kong, F., Gilbert, G.L., Cao, B., Wang, L., Feng, L. Development of a DNA microarray to identify the Streptococcus pneumoniae serotypes contained in the 23-valent pneumococcal polysaccharide vaccine and closely related serotypes. J Microbiol Methods 68 (2007) 128-136. 

Structures of Some of the Capsular Polysaccharides of Streptococcus pneumoniae Contained in the Current, Pneumococcal Vaccine... 

Nayak, A. R., Tinge, S. A., Tart, R. C., McDaniel, L. S., and Briles, D. E., 3rd, and Curtiss, R. (1998), A live recombinant avirulent oral Salmonella vaccine expressing pneumococcal surface protein A induces protective responses against Streptococcus pneumoniae, Infect. Immun., 66,3744—3751. 

Pneumococcal vaccine is composed of a saline solution containing the purified capsular polysaccharides of 23 types of Streptococcus pneumoniae. The improved 23-valent vaccine, which replaced a 14-valent vaccine at the beginning of the 1980s, contains antigens to pneumococcal types that are responsible for about 85% of bacteremic pneumococcal pneumonia. 

Binder, C.J. et al. Pneumococcal vaccination decreases atherosclerotic lesion formation molecular mimicry between Streptococcus pneumoniae and oxidized LDL. Nat. Med. 9 (2003) 736 3. 

Pneumococcal vaccine is a bacterial vaccine that induces antibodies against 23 capsular types of Streptococcus pneumoniae. The type-specific antibody facilitates bacterial destruction by complement-mediated lysis. It is indicated in protection against pneumococcal pneumonia, pneumococcal bacteremia, and other pneumococcal infections. This bacterial vaccine is used for pneumococcal immunization. 

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