Streptococcus capsular polysaccharide

By applying the NOESY step first, this experiment allows us to jump from one spin system to another or to overcome a bottleneck in TOCSY transfer caused by an occurrence of a small coupling constant in the chain of J-connectivities. Both these features are illustrated in ID NOESY-TOCSY spectra of the type VI group B Streptococcus capsular polysaccharide (1). 

Other examples include a branched trisaccharide of the type lA group B Streptococcus capsular polysaccharide, GlcNAc(pi-3)[Glc(pi-6)]Glc, was synthesised and characterised using HSQC and P NMR Schaffer et al. characterised a pyrophosphate bridge which links the pyruvate-containing... 

Vaccines can be roughly categorized into killed vaccines and Hve vaccines. A killed vaccine can be (/) an inactivated, whole microorganism such as pertussis, (2) an inactivated toxin, called toxoid, such as diphtheria toxoid, or (J) one or more components of the microorganism commonly referred to as subunit vaccines. The examples are capsular polysaccharide of Streptococcus pneumoniae and the surface antigen protein for Hepatitis B vims vaccine. 

The type-specific capsular polysaccharide from Streptococcus pneumoniae type 5 contains 2-acetamido-2,6-dideoxy- -D-x>>/o-hexopyranosyl-4-ulose residues (17). Sugar nucleotides of hexos-4-uloses are important intermediates in the transformation of sugars during the biosynthesis, but this is the only known example of such a sugar as a polysaccharide component. 

The pyruvic acid may also be linked to vicinal positions. When linked to 0-3 and 0-4 of a D-galactopyranosyl residue (40), the dioxolane ring becomes cw-fused. In the limited number of known examples, the absolute configuration at the acetalic carbon atom is (S), as in 40. There are some examples of tra -fused dioxolane rings, and these are more sensitive to hydrolysis with acid than the others. Thus, pyruvic acid is acetalically linked to 0-3 and 0-4 of an a-L-rhamnopyranosyl residue in the Klebsiella type 72 capsular polysaccharide, to 0-2 and 0-3 of an a-D-galactopyranosyl residue in the Streptococcus pneumoniae type 4 capsular polysaccharide, and to 0-2 and 0-3 of a S-D-glucopyranosyluronic acid residue in the Klebsiella K1 capsular polysaccharide. " In the extracellular polysaccharide from... 

There are solitary examples of other alditol phosphates as components of this class of polymers. Arabinitol 1-phosphate is part of the S. pneumoniae type 17F capsular polysaccharide. o-Glucitol 6-phosphate is a component of the group-specific polysaccharide from group B Streptococcus, which has a most unusual, ramified structure. In a polysaccharide from Nocardia... 

The pneumococci all belong to different types of the same species, namely, Streptococcus pneumoniae. This was earlier called Diplococcus pneumoniae, but has been renamed.5 6 7 There are some 80 different types of pneumococcus, and two systems of nomenclature, the Danish, used in Europe, and Eddy s, used in the United States.8 Tables correlating the Danish and American designations have been published.8 The Danish system, with Arabic numerals and common abbreviations, such as Phi for Type 1 and SI for its type-specific, capsular polysaccharide, will be used in this article. 

Pneumococcal vaccine is a mixture of capsular polysaccharides from 23 of the 83 most prevalent types of Streptococcus pneumoniae seen in the United States. 

SGQARVLYSEFINAL mAb4 Streptococcus pneumoniae 4 capsular polysaccharide [62]... 

Pneumococcal vaccine, polyvalent [FDA former] Streptococcus pneumonia capsular polysaccharide vaccine [SY]... 

Apart from L-fucose, 3-amino-3,6-dideoxy-D-galactose169 and the D (Ref. 170) and L (Ref. 171) enantiomers of 2-amino-2,6-dideoxygalac-tose (fucosamine) have been identified in bacterial LPS. 2-Acetamido-4-amino-2,4,6-trideoxy-D-galactopyranose has been isolated1710 from the capsular polysaccharide of Streptococcus pneumoniae. 

T. Sugawara and K. Igarashi, Synthesis of a trisaccharide component of the capsular polysaccharide of Streptococcus pneumoniae Type 19F, Carbohydr. Res. 772 195 (1988). 

Epimerization at C-2 of UDP-GlcNAc, leading to the UDP derivative of 2-acetamido-2-deoxy-D-mannose, was also observed115 118 the monosaccharide was identified as a constituent of several capsular polysaccharides from Streptococcus pneumonia119-122 and Neisseria meningitidis group A (Ref. 123), the teichuronic acid of Bacillus cereus,124 and the O-specific... 

K. Leontein, B. Lindberg, J. Lonngren, and D. J. Carlo, Structural studies of the capsular polysaccharide from Streptococcus pneumoniae Type 12 A, Carbohydr. Res., 114 (1983) 257-266. 

---