Genes overexpression

Lei B, S-C Tu (1996) Gene overexpression, purification, and identification of a desulfurization enzyme from Rhodococcus sp. strain IGTS8 as a sulfide/sulfoxide monooxygenase. J Bacteriol 178 5699-5705. 

Node positive (1-3 involved nodes) and HER2/neu gene overexpressed or amplified... 

Lei, B. F., and Tu, S. C., Gene Overexpression, Purification, and Identification of a Desulfurization Enzyme From Rhodococcus Sp Strain IGTS8 as a Sulfide/Sulfoxide Monooxygenase. Journal of Bacteriology, 1996. 178(19) pp. 5699-5705. 

Nakayama, N. Matsubara, T. Ohshiro, T., et al., A Novel Enzyme, 2 -Hydroxybiphenyl-2-Sulfinate Desulfinase (DszB), From a Dibenzothiophene-Desulfurizing Bacterium Rhodococcus Erythropolis KA2-5-1 Gene Overexpression and Enzyme Characterization. Biochimica Et Biophysica Acta-Proteins and Proteomics, 2002. 1598(1-2) pp. 122-130. 

Villaret DB et al. Identification of genes overexpressed in head and neck squamous cell carcinoma using a combination of complementary DNA subtraction and microarray analysis. Laryngoscope 2000 11 374-381. 

Couillard-Despres, S., Zhu, Q., Wong, P. C., Price, D. L., Cleveland, D. W. and Julien, J. P. Protective effect of neurofilament heavy gene overexpression in motor neuron disease induced by mutant superoxide dismutase. Proc. Natl Acad. Sci. U.S.A. 95 9626-9630,1998. 

Transgene of osteoprotegerin gene Overexpressed Osteoprotegerin Osteopetrosis without osteoclasts Deficiency of l3miph nodes, T and B cell deficiency... 

Macrophage invasion — the up-regulation of the macrophage mannose receptor, cathepsin S, and macrophage capping protein. Up-regulation of irramme response genes — overexpression of major histocompatibility complex (MHC) and IgG. 

Namy O, Duchateau-Nguyen G, Rousset JP (2002) Translational readthrough of the PDE2 stop codon modulates cAMP levels in Saccharomyces cerevisiae. Mol Microbiol 43 641-652 Namy O, Hatin 1, Stahl G, Liu H, Barnay S, Bidou L, Rousset JP (2002) Gene overexpression as a tool for identifying new trans-acting factors involved in translation termination in Saccharomyces cerevisiae. Genetics 161 585-594... 

An elegant approach using three bacterial genes overexpressed in Desiree achieved a 20-fold increase in total carotenoids to 114 p-g/G DW and a 3600-fold increase in B-carotene to 47 pg/g DW (Diretto et al., 2007). A 250 g serving of these potatoes was estimated to provide 50% of the RDA of vitamin A. Potatoes engineered to have higher zeaxanthin levels were fed to human subjects and the zeaxanthin was found to be readily bioavailable (Bub et al., 2008). 

The elevation of serum concentration of kallikreins in cancer might be a result of the increased vasculature (angiogenesis), the destruction of the glandular architecture of the tissues involved, and the subsequent leakage of these proteins into the general circulation. It is possible that the concentration of kallikreins may also be increased in serum because of gene overexpression. 

Mahon FX, Belloc F, Lagarde V, Chollet C, Moreau-Gaudry F, Reiffers J, Goldman JM, Melo JV (2003) MDR1 gene overexpression confers resistance to imatinib mesylate in leukemia cell line models. Blood 101, 2368-2373. 

Anazawa Y, Nakagawa H, Furihara M, Ashida S, Tamura K, Yoshioka H, et al. PCOTH, a novel gene overexpressed in prostate cancers, promotes prostate cancer cell growth through phosphorylation of oncoprotein TAF-Ibeta/SET. Cancer Res 2005 65(11) 4578-4586. 

The mechanism by which the KCNK9 gene overexpresses in human colorectal cancers is a good example of chromosomal gain or genomic amplification. Mu et al. (2003) have identified KCNK9 as a new protooncogene... 

Protection against this effect was achieved by transfection of cells with PHGPx gene. Overexpression of PHGPx has been shown to suppress cell death that is due to oxidative damage. 

Schneider, E., Horton, J. K., Yang, C. H., Nakagawa, M., Cowan, K. H. (1994). Multidrug resistance-assodated protein gene overexpression and reduced drug sensitivity of topoisomerase II in a human breast cardnoma MCE7 cell line seleded for etoposide resistance. Cancer Res. 54,152-158. 

Fig. 2 Cell taggers are genes expressed predominantly in particular immune cell subsets, (a) This heat map depicts the cell subset expression of genes overexpressed in the whole blood of Multiple Sclerosis patients (MS) (b) Heat map of genes underexpressed in whole blood of MS patients and (c). the percentage of dys-regulated genes from each cell subset from the overexpressed and undexpressed gene sets...

Koffas, M.A. Jung, G.Y. Stephanopoulos, G. Engineering metabolism and product formation in Corynebacterium glutamicum by coordinated gene overexpression. Metab. Eng. 2003, 5 (1), 32-41. 

Vital-Lopez et al. (2006) used a linearized kinetic model, possibly anticipating a complex problem to be solved, as the basis for maximizing serine production. In their study, gene overexpression/repression and... 

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