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Adenoma, hepatocellular

A 2-year carcinogenicity bioassay of tricresyl phosphate in mice and rats showed no evidence of carcinogenicity in these species (NTP 1994). Doses (consumed in feed) were <37 mg/kg/day in mice and < 15 mg/kg/day in rats. Dietary administration of tributyl phosphate was associated with transitional and squamous cell carcinomas of the bladder in rats after 2 years of exposure at 143.3 mg/kg/day (FMC 1994a). An increased incidence of hepatocellular adenomas in the liver was observed in mice after dietary administration of 455 mg/kg/day tributyl phosphate for 18 months (FMC 1994b). [Pg.131]

Category C (possible human carcinogen) was evidenced by a dose-related increase in the incidence of leiomyosarcomas in the urinary bladder, a significant dose-related trend for combined hepatocellular adenomas and carcinomas in males, and a significantly higher incidence of combined lung adenomas and carcinomas in females. For the purpose of risk characterization, the RfD approach should be used for quantification of human cancer risk. The chronic exposure analysis revealed <100% RfD, and it is assumed that the chronic dietary endpoint is protective for cancer dietary exposure [64]. [Pg.94]

D-Phenothrin (I) Not likely to be carcinogenic to humans. Rat liver tumors occurred only at excessively toxic doses (limit dose) and mouse hepatocellular adenomas, which are common, did not achieve statistical significance (p < 0.01). Additionally, acceptable mutagenicity studies were negative for mutagenic potential [97] No tumorigenicity was observed [11]. [Pg.96]

Mouse (B6C3F1) 2 yr 5 d/wk 6 hr/d 9018° F (CEL increased incidence of hepatocellular adenomas and carcinomas) Biodynamics 1995b Mixed Hexanes... [Pg.46]

No skin cancer was reported in B6C3Fj mice chronically exposed to 250 and 500 mg/kg/day of JP-5 (NTP/NIH 1986). There was a 2-6% incidence of squamous cell papilloma and/or carcinoma of the skin in B6C3Fj mice chronically exposed to 250 (females only) or 500 (both sexes) mg/kg/day marine diesel fuel. The effect did not occur in the control groups the statistical significance of these effects was not reported. Hepatocellular adenoma or carcinoma were noted in males exposed to 250 and 500 mg/kg/day... [Pg.74]

In an NTP carcinogenicity study, rats and mice of both sexes were fed DEHA at 12,000 and 2 5,000 ppm in the diet for 103 weeks. DEHA was noncarcinogenic in rats but caused hepatocellular carcinomas in female mice in both dose groups and hepatocellular adenomas in males at the higher dose. The species difference in carcinogenicity is consistent with a greater extent of peroxisome proliferation in liver of mice as compared to rats. ... [Pg.250]

High doses of dioxane by oral administration produced malignant tumors of the nasal cavity and liver in rats, and mmors of the liver and gallbladder in guinea pigs." Rats administered either 0.5% or 1.0% (vol/vol) in the drinking water had squamous cell carcinomas of the nasal turbinates hepatocellular adenomas were seen in the dosed females." In another study, inhalation of 111 ppm, 7 hours/day, 5 days/week for 2 years did not result in any increased tumor incidence in rats. ... [Pg.282]

In 2-year gavage studies there was some evidence of carcinogenic activity in male rats based on increased incidences of cholangiocar-cinomas and bile duct dysplasia and fibrosis. There was also some evidence of carcinogenicity in female mice based on increased incidences of hepatocellular adenomas. Male mice showed clear evidence of carcinogenicity based on increased incidences of hepatocellular adenomas and carcinomas. The development of liver tumors may be related to the chronic inflammatory effects noted at this site. In another experiment with hamsters, exposure to furfural vapor 7 hours/day, 5 days/week for 1 year caused irritation of the nasal mucosa and growth retardation but no evidence of carcinogenic effects. ... [Pg.354]

Mice were administered 250 or 500mg/ kg/day pentachloroethane by gavage for life. The hepatic carcinogenicity of pentachloroethane was clearly established despite reduced survival rates. The incidence of hepatocellular carcinomas was significantly increased in low-dose males and in treated females there also was a significant dose-related increase in the incidence of hepatocellular adenomas in treated females. ... [Pg.557]

In male rats dosed by gavage at doses up to 60mg/kg, spontaneous seizures occurred at 12.5 mg/kg, the lowest dose used. Chronic oral studies in rats revealed no evidence of neoplasms, whereas one study in mice found an increased incidence of combined hepatocellular adenomas and carcinomas in females. It has been noted that these mmors in mice are poor predictors for malignancy in other species. A number of studies suggest that RDX is not mutagenic. ... [Pg.617]

Carcinogenesis In a lifetime carcinogenicity study carried out in B6C3F1 mice, racemic methylphenidate caused an increase in hepatocellular adenomas and, in males only, an increase in hepatoblastomas at a daily dose of approximately 60... [Pg.1148]

Carcinogenesis In mice, a dose-related increase in the incidence of hepatocellular adenomas was observed with oxcarbazepine. [Pg.1276]

Hepatic function impairment Amprenavir is principally metabolized by the liver exercise caution when administering this drug to patients with hepatic impairment. Carcinogenesis Results showed an increase in the incidence of benign hepatocellular adenomas and an increase in the combined incidence of hepatocellular adenomas plus carcinoma in males of both species at the highest doses tested. [Pg.1824]

Carcinogenesis Hepatocellular adenomas and carcinomas were increased at all doses in rats and mice. [Pg.1889]

B artolozzi C, Lencioni R, Paolicchi A, et al. Differentiation of hepatocellular adenoma and focal nodular hyperplasia of the liver comparison of power Doppler imaging and conventional color Doppler sonography. EurRadiol 1997 7 1410-1415. [Pg.375]

Coumarin has been adequately tested by oral administration in two experiments in mice and in one experiment in rats. In mice of one strain, it produced increases in lung tumours (adenomas and carcinomas) in both males and females and in hepatocellular adenomas in females. There was no increase in tumour incidences in another strain of mouse. In one study in rats, coumarin produced a low incidence of renal tubule adenomas in males, seen only after step-sectioning of the kidney. Three other studies in rats could not be evaluated. [Pg.216]

Diethanolamine was tested for carcinogenicity by dermal application in one study in mice and in one study in rats. In the mouse study, there was a treatment-related increase in the incidences of both hepatocellular adenomas and carcinomas in both males and females, as well as an increase in the incidence of hepatoblastomas in males. There was also a marginal increase of renal tubule adenomas in males. In rats, no treatment-related increase in the incidence of tumours was seen in either males or females. [Pg.373]

Adenomas and adenocarcinomas Squamous-cell papillomas Hepatocellular adenomas and carcinomas Adenocarcinomas... [Pg.473]

Nitromethane was tested for carcinogenicity by inhalation in one experiment in mice and in two experiments in rats. In mice, it increased the incidence of Harderian gland and lung tumours in males and females as well as of hepatocellular adenomas in females. In one experiment in rats, nitromethane increased the incidence of benign and malignant mammary gland tumours in females, but produced no increase in the incidence of tumours in a second study in a different strain of rat. [Pg.498]


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See also in sourсe #XX -- [ Pg.397 ]




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