Solvent casting and particulate leaching

In order to overcome some of the drawbacks associated with the fiber bonding preparation, a solvent-casting and particulate-leaching technique was developed [32], With appropriate thermal treatment porous constructs of synthetic biode-... 

Fig. 4a, b. Scanning electron photomicrographs of amorphous poly(L-lactic acid) foams a 92% porosity and 30 pm median pore diameter b and 91% porosity and 94 pm median pore diameter. Prepared by a solvent-casting and particulate-leaching method [32] using 90 wt% sieved sodium chloride particles of size range between 0-53 pm and 106-150 pm, respectively... 

Highly porous membranes with an inter-connected pore structure were produced using this solvent-casting and particulate-leaching technique (Fig. 4a, b). The porosity of porous PLLA membranes could be controlled by varying the amount of salt used to construct the composite material (Fig. 5a). 

Solvent casting and particulate leaching This approach allows the preparation of porous structures with regular porosity. Other than the small thickness range that can be obtained, another drawback of such scaffolds lies in the use of organic solvents, which must be fully removed to avoid any possible damage... 

The lack of control over pore size is a major issue for methods such as fiber bonding, but solvent casting and particulate leaching (SC-PL) allows for fine control over pore... 

Solvent casting and particulate leaching Controllable porosity, up to 93% Limit of membranes up to a thickness of 3 mm... 

Porous 3D polymeric scaffolds with HAp for bone regeneration are fabricated by solvent casting and particulate leaching, melt moulding, emulsion freeze drying, gas foaming, electrospinning, thermaily induced phase separation or solid freeform fabrication (SFF) (Table 3). 

Solvent casting and particulate leaching (SC/PL) is a simple and commonly used method for fabricating scaffolds for tissue engineering. With an appropriate thermal treatment, porous constructs of synthetic biodegradable polymers can be prepared with specific porosity, surfaceivolume ratio, pore size and crystallinity for different applications. This method involves mixing water-soluble salt (e.g. sodium chloride, sodium citrate) particles into a polymer solution. The mixture is then cast into the mould of the desired shape. After the solvent is removed by evaporation or lyophilization, the salt particles are leached out to obtain a porous structure with the pore shape limited to the cubic crystal shape of the salt. Removal of soluble particles from the interior of a polymer matrix is difficult and limits the thickness of the films prepared to ca. 2 mm [293]. 

Solvent casting and particulate leaching PLGA/HAp Gelatine 23-52 im Salt 67-167 im Open-cell Porogens either gelatin microspheres or NaCl salt particles [154]... 

---