Microspheres gelatin

Data on the biocompatibility of gelatin microspheres is extremely limited. Drug-free microspheres elicited no untoward effects when injected intravenously into mice over a 12-week period (159). When albumin microspheres were injected repeatedly into the knee joints of rabbits, pronounced rapid joint swelling occurred after the second and subsequent injections. By comparison, no swelling occurred when gelatin microspheres were administered (160). 

Magnetically responsive gelatin microspheres, prepared using methods adopted from albumin preparations (161), were evaluated... 

As was the case with albumin, reports on clinical studies employing gelatin microspheres are limited and confined to Japan. Bleomycin, contained in a microsphere-in-oil formulation, was targeted to the lymph nodes for the treatment of infantile cystic hygroma, a benign tumor (143). Successful treatment was noted in all cases. 

H. Sezaki, M. Hashida, and S. Muranishi, Gelatin microspheres as carriers for antineoplastic agents, in Optimization of Drug Delivery (H. Bundgaard, A. B. Hansen, and H. Kofod, eds.), Munksgaard, Copenhagen, 1982, p. 316. 

J. Wang, Y. Tabata, and K. Morimoto. Aminated gelatin microspheres as a nasal delivery system for peptide drugs Evaluation of in vitro release and in vivo insulin absorption in rats. J Control Release 113 31-37 (2006). 

Fig. 6. Scanning electron photomicrograph of a PLGA 50 50 scaffold in the shape of a half-cylinder prepared by a melt molding method [35] using 35 wt% gelatin microspheres with diameters in the size range 300-500 pm. (Reproduced with permission from [35])...

Morimoto, K., Katsumata, H., Yabuta, T., et al. (2000). Gelatin microspheres as a pulmonary delivery system Evaluation of salmon calcitonin absorption. J. Pharm. Pharmacol., 52, 611-617. 

Wang, J., et al. 2000. Positively charged gelatin microspheres as gastric mucoadhesive drug delivery system for eradication of H. pylori. Drug Deliv 1 231. 

Sakakibara Y Nishimura K, Tambara K, et al. Prevascularization with gelatin microspheres containing basic fibroblast growth factor enhances the benefits of cardiomyocyte transplantation. J Thorac Cardiovasc Surg 2002 124 50-56. 

Gelatin Microspheres Several studies characterizing gelatin microspheres as a nasal drug delivery system have been reported. Gelatin microspheres were shown... 

Brime, B., Ballesteros, M. P., and Frutos, P. (2000), Preparation and in vitro characterization of gelatin microspheres containing Levodopa for nasal administration, J. Micro-encapsul., 17,777-784. 

Vandelli, M.A. Rivasi, P. Guerra, P. Forni, F. Arletti, R. Gelatin microspheres crosslinked with D, L-glyceraldehyde as a potential drug delivery system preparation, characterisation, in vitro and in vivo studies. Int. J. Pharm. 2001,215, 175-184. 

Narayani, R. Rao, K.P. Gelatin microsphere cocktails of different sizes for the controlled release of anticancer drugs. Int. J. Pharm. 1996, 143, 255-258. 

Fig. 6. A SEM photograph of gelatin microspheres crosslinked with glutaraldehvde...

Adekogbe I, Ghanem A (2005) Fabrication and characterization of DTBP-crosslinked chitosan scaffolds for skin tissue engineering. Biomaterials 26 7241-7250 Liu FI, Fan FI, Cui Y et al (2007) Effects of the controlled-released basic fibroblast growth factor from chitosan-gelatin microspheres on a chitosan-gelatin scaffold. Biomacromolecules 8 1446-1455... 

---