Solid substrate fermentation

Processes have been developed in North America to pilot scale growing the bacterium Cellulomonas or the fungus Trichoderma on pre-treated milled cellulosic material in conventional fermentors, ie in a liquid medium. However, preparation costs are considerably higher than with solid-substrate fermentations. 

Only this fungus amongst those listed is capable of using the cellulose of which paper is composed. Solid substrate fermentation would be foe easiest and cheapest production system. 

An improved procedure for the production of the tremorgenic mycotoxins trypto-quivaline and tryptoquivalone by Aspergillus clavatus, has been reported this makes use of pearled barley in a procedure based on Hesseltine s solid substrate fermentation technique. 

Zhang, W. J., Xu, Z. R., Sun, J. Y., and Yang, X. (2006a). Effect of selected fungi on the reduction of gossypol levels and nutritional value during solid substrate fermentation of cottonseed meal.. Zhejiang. Univ. Sci. B 7, 690-695. 

Nwe N, Stevens WF (2002) Production of fungal chitosan by solid substrate fermentation followed by enzymatic extraction. Biotechnol Lett 24 131-134... 

Laukevics JJ, Apsite AF, Viesturs UE (1984) Solid substrate fermentation of wheat straw to fungal protein. Biotechnol Bioeng 26 1465-1474... 

By solid substrate fermentation, T-2 toxin can be produced at approximately 9 g/kg of substrate, with a yield of 2 to 3 g of crystalline product.32 Several of the trichothecene mycotoxins have been produced in liquid culture at medium yields and large volumes of culture for extraction.33 Thus, using existing state-of-the-art fermentation processes that... 

Blanch HW, Clark DS (1997) Biochemical engineering. Marcel Dekker, New York, 702 pp Bogar B, Szakacs G, Tengerdy RP et al. (2002) Production of tilpha-amylase with Aspergillus oryzae on spent brewing grain by solid substrate fermentation. Appl Biochem Biotechnol 102-... 

Bogar B, Szakacs G, Linden JC et al. (2003) Optimization of phytase production by solid substrate fermentation. J Ind Microbiol Biotechnol 30(3) 183—189 Bojorge N, Valdman B, Acevedo F et al. (1999) A semi-structured model for the growth tmd p-galactosidase production by fed-batch fermentation with Ktuyveromyces marxianus. Bioproc Eng 21 313-318... 

George S, Raju V, Subramanian TV et al. (1997) Comparative study of protease production in solid substrate fermentation versus submerged fermentation. J Bioproc Biosys Eng 16(6) 381-382 Gerday G, Aittaleb M, Bentahir M (2000) Cold-adapted enzymes from fundamentals to biotechnology. TIBTECH 18 103-107... 

Illanes A, Aroca G, CabeUo L et al. (1992) Solid substrate fermentation of leached beet pulp with Trichoderma aureoviride. World J Microbiol Biotechnol 8 488-493 Illanes A, Acevedo F, Gentina J et al. (1994) Production of penicillin acylase from Bacillus mega-terium in complex and defined media. Proc Biochem 29(4) 263-270 Illanes A, Acevedo F, Gentina JC et al. (1995) Pilot-plant production and evaluation of yeast lactase. Paper presented at the Seventh European Congress on Biotechnology, Nice, France, February 15-19, 1995... 

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