Aspergillus clavatus

Antimicrobial agent and suspect animal carcinogen Patulin. Isolated from a number of fungi, Aspergillus clavatus, etc. 

Aspergillus clavatus Neosartorya fischeri Aspergillus fumigatus... 

Arabidopsis thaliana Oryza sativa T h a 1 ict r um f 1 avuiti Papaver somniferuiti Aristolochia contorta Petrosel inum crispuiti Rhodiola sachalinensis St igmate1la aurantiaca Pseudomonas entomophila Pseudomonas putida Aspergillus clavatus Neosartorya fischeri Drosophila melanogaster. ..TEF.KR. Apis mellifera. .IQEF.VR. 

Cellulose was reported as a wall constituent of the conidiophores of Aspergillus niger, based on the physical appearance of the fibrils. However, walls of Aspergillus niger and Aspergillus clavatus were shown to be insoluble in Schweizer reagent and to contain chitin. The cell walls of Haplosporangium parvum were reported to contain... 

An improved procedure for the production of the tremorgenic mycotoxins trypto-quivaline and tryptoquivalone by Aspergillus clavatus, has been reported this makes use of pearled barley in a procedure based on Hesseltine s solid substrate fermentation technique. 

Aspergillus clavatus, A. giganteus, A. terreus, and Byssochlamys nivea (Davis and Diener, 1987). 

Tremor-inducing mycotoxins were isolated from the mold Aspergillus clavatus, which infests rice. The mycotoxins were tetrapeptides of anthranilic acid (source of the quinazolin-4-ones), trypotophan, valine, and methyl-alanine or alanine. They were named tryptoquivaline (116 = OH,... 

Tremor-inducing mycotoxins were isolated from the mold Aspergillus clavatus, which infests rice. The mycotoxins were tetrapeptides of anthranilic acid (source of the quinazolin-4-ones), trypotophan, valine, and methyl-alanine or alanine. They were named tryptoquivaline (116 R1 = OH, R2 = R3 = Me X = H, OAc) and nortryptoquivalone (116 R =OH R2 = Me R3 = H X = O). The structures of the metabolites were deduced from spectral data, from the X-ray crystallographic analysis of the p-bromo-phenylurethan derivative of a transformation product of tryptoquivaline, and from chemical studies.259... 

Seifert R.M. and King A.D. Jr (1982) Identification of some volatile constituents of Aspergillus clavatus. 

Crystallographic parameters were determined for the pyrimido[2,l- 7][l,3]oxazine (215) <67RS970>. The lFf-[l,4]oxazino[3,4-ft]quinazolin-(4//)3-one (tricyclic lactone) skeleton was demonstrated for the methanolysis product of triptoquivaline, a metabolite of Aspergillus clavatus <75JA663>. 

Another substance P inhibitor was isolated from the mycelial extract — fiscalin B (10), which was originally isolated from Neosartorya fischeri by Sterling -Winthrop labs [46]. The fiscalins are structurally similar to the tremorgenic tryptoquivaline mycotoxins produced by Aspergillus clavatus [47] and A. fumigatus [48]. Fiscalin B was purified by reverse phase HPLC (Rainin C8 semipreparative, 50% methanol/water - 100% methanol) of the initial silica gel fraction 12. 

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