Solid-state nuclear magnetic resonance pharmaceutical applications

DE Bugay. Solid-state nuclear magnetic resonance spectroscopy Theory and pharmaceutical applications. Pharm Res 10(30) 317-327, 1993. 

Byrn SE, Bugay DE, Tishmack PA. Solid state nuclear magnetic resonance spectroscopy—pharmaceutical applications. J Pharm Sci 2003 92(3) 441-474. 

One technique that is becoming increasingly important for the characterization of materials is that of solid-state nuclear magnetic resonance (NMR) spectroscopy, and the application of this methodology to topics of pharmaceutical interest has been amply demonstrated.The NMR spectra of polymorphs or solvatomorphs often contains non-equivalent resonance peaks for analogous nuclei since the intimate details of the molecular environments associated with differing crystal structures can lead to perturbations in nuclear resonance energies. 

Solid-state nuclear magnetic resonance (SSNMR) spectroscopy is a powerful technique used in the analysis of solids, and is currently finding more and more applications, particularly in the analysis of pharmaceutical formulations. It is a non-destructive, non-invasive technique that can be employed to simultaneously examine the physical and chemical states of both the active pharmaceutical ingredient (API) and the excipients present as they exist within the formulation. It is also highly selective, as nuclei of the API often have different chemical shifts than do common excipients. 

Tishmack, P.A. Bugay, D.E. Byrn, S.R. Solid-state nuclear magnetic resonance spectroscopy— pharmaceutical applications. J. Pharm. Sci. 2003, 92, 441-474. 

Y Aboul-Enein. Applications of solid-state nuclear magnetic resonance spectroscopy to pharmaceutical research. Spectroscopy 5 32-33, 1990. 

R 598 L. K. Thompson, Unraveling the Secrets of Alzheimer s j3-Amyloid Fibrils , P. Natl. Acad. Sci. U. S. A., 2003,100, 383 R 599 T. Timusk, The Mysterious Pseudogap in High Temperature Superconductors An Infrared View , Solid State Commun., 2003,127, 337 R 600 P. A. Tishmack, D. E. Bugay and S. R. Byrn, Solid-State Nuclear Magnetic Resonance Spectroscopy - Pharmaceutical Applications , J. Pharm. Sci., 2003, 92,441... 

Tishmack PA, Bugay DE, and Byrn SR (2003) Solid-state nuclear magnetic resonance spectroscopy - pharmaceutical applications./owma/ of Pharmaceutical Sciences 92 577-610. 

Volume 83 of Annual Reports on NMR Spectroscopy commences with an interesting account of Dynamic Pictures of Proteins by NMR from H. Saito this is followed by a report on Recent Progress in the Solid-State NMR Studies of Short Peptides—Techniques, Structure and Dynamics by A. Jezioma, S. Kazmierski, P. Paluch, E. Skorupska and M. J. Potrzebowski an account of Solid-State NMR Studies of Biomolecules is presented by A. Wong and F. PoU G. A. Monti, A. K. Chattah and Y. G. Linck report on Solid-State Nuclear Magnetic Resonance in Pharmaceutical Compounds the final report by M. Jaeger andR. L. E. G. Aspers is on Covariance NMR and Small-Molecule Applications . 

See also Extraction Solid-Phase Extraction. Food and Nutritional Analysis Oils and Fats Fruits and Fruit Products. Lab-on-a-Chip Technologies. Liquid Chromatography Liquid Chromatography-Nuclear Magnetic Resonance Spectrometry. Nuclear Magnetic Resonance Spectroscopy Oven/iew Principles Instrumentation. Nuclear Magnetic Resonance Spectroscopy Applications Food. Nuclear Magnetic Resonance Spectroscopy Techniques Solid-State. Peptides. Radiochemical Methods Radiotracers Pharmaceutical Applications. 

See alscr. Nuclear Magnetic Resonance Spectroscopy Overview Principles. Nuclear Magnetic Resonance Spectroscopy Applications Pharmaceutical. Nuclear Magnetic Resonance Spectroscopy Techniques Solid-State. 

Nuclear magnetic resonance (NMR) spectroscopy in pharmaceutical research has been used primarily in a classical, organic chemistry framework. Typical studies have included (1) the structure elucidation of compounds [1,2], (2) investigating chirality of drug substances [3,4], (3) the determination of cellular metabolism [5,6], and (4) protein studies [7-9], to name but a few. From the development perspective, NMR is traditionally used again for structure elucidation, but also for analytical applications [10]. In each case, solution-phase NMR has been utilized. It seems ironic that although —90% of the pharmaceutical products on the market exist in the solid form, solid state NMR is in its infancy as applied to pharmaceutical problem solving and methods development. 

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