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Solid-phase extraction quantification

J. A. Pascual and J. Sanagustin, Eully automated analytical method for codeine quantification in human plasma using on-line solid-phase extraction and high-perfomance liquid clrromatogi aphy with ulti aviolet detection , 7. Chromatogr. B 724 295-302 (1999). [Pg.295]

Klejdus, B. et al.. Solid-phase extraction of 4(5)-methylimidazole (4-MeI) and 2-acetyl-4(5)-(l,2,3,4-tetrahydroxybutyl)-imidazole (THI) from foods and beverages with subsequent liquid chromatographic-electrospray mass spectrometric quantification, J. Sep. ScL, 29, 378, 2006. [Pg.345]

Fractions are concentrated under vacuum below 35°C. Alternatively, they can be purified and concentrated by solid phase extraction (SPE) before identification and quantification, which is a valuable procedure for samples containing low amounts of pigments. After concentration, fractions can be stored in small flasks, protected from light, sealed under inert atmosphere, and kept below -20°C until analysis. [Pg.432]

Lundanes E, Jara S, Lysebo C, Greibrokk T (2000) Determination of phthalates in water samples using polystyrene solid-phase extraction and liquid chromatography quantification. Anal Chim Acta 407 165-171... [Pg.134]

De la Torre-Carbot K, Jauregui O, Gimeno E, Castellote AI, Lamuela-Raventos RM and Lopez-Sabater M. 2005. Characterization and quantification of phenolic compounds in olive oils by solid-phase extraction, HPLC-DAD, and HPLC-MS/MS. J Agric Food Chem 53(11 ) 4331 —4340. [Pg.82]

Chao M. et al., 2005. Rapid and sensitive quantification of urinary N7-mthelguanine by isotope-dilution liquid chromatography/electrospray ionization tandem mass spectrometry with online solid-phase extraction. Rapid Commun Mass Spectrom 19 2427. [Pg.294]

Gon9alves J.C.S. et al., 2005. Online solid-phase extraction coupled with high-performance liquid chromatography and tandem mass spectrometry (SPE HPLC-MS-MS) for quantification of bromazepam in human plasma. Ther Drug Monit 27 601. [Pg.294]

Pozo O.J. et al., 2006. Efficient approach for the reliable quantification and confirmation of anitbiotice in water using online solid-phase extraction liquid chromatography/tandem mass spectrometry. J Chromatogr A 1103 83. [Pg.296]

Recent studies, including the use of Microtox and ToxAlert test kits [55,56], were carried out for the determination of the toxicity of some non-ionic surfactants and other compounds (aromatic hydrocarbons, endocrine disruptors) before implementation on raw and treated wastewater, followed by the identification and quantification of polar organic cytotoxic substances for samples with more than 20% inhibition. Furthermore, the study of their contribution to the total toxicity was obtained using sequential solid-phase extraction (SSPE) before liquid chromatography-mass spectrometry (LC-MS) detection. This combined procedure allows one to focus only on samples containing toxic substances. [Pg.263]

In order to study simultaneously the behaviour of parent priority surfactants and their degradation products, it is essential to have accurate and sensitive analytical methods that enable the determination of the low concentrations generally occurring in the aquatic environment. As a result of an exhaustive review of the analytical methods used for the quantification within the framework of the three-year research project Priority surfactants and their toxic metabolites in wastewater effluents An integrated study (PRISTINE), it is concluded that the most appropriate procedure for this purpose is high-performance (HP) LC in reversed phase (RP), associated with preliminary techniques of concentration and purification by solid phase extraction (SPE). However, the complex mixtures of metabolites and a lack of reference standards currently limit the applicability of HPLC with UV- or fluorescence (FL-) detection methods. [Pg.25]

Fish. Solid biota samples, mainly fish, should be quickly killed by liquid N2 [28] or cervical dislocation [32] and kept at low temperatures (— 20°C). Some authors preferred desiccation of the sample at high temperature (70°C) [33,34] or lyophylisation [28]. The extraction and isolation steps would be combined when using lyophylisation and homogenisation, followed by a Soxhlet extraction, usually with MeOH, and a subsequent solid-phase extraction (SPE) clean-up, prior to the quantification. [Pg.462]

Schindler BK, Eoerster K, Angerer J (2009b) Quantification of two urinary metabolites of organophosphorus flame retardants by solid-phase extraction and gas chromatography-tandem mass spectrometry. Anal Bioanal Chem 395 1167-1171... [Pg.304]

For reliable identification of a residue, detailed information about the molecular structure of the analyte is essential. The total information about the molecular structure of the analyte is the sum of the information derived from each individual analytical step of tire method. Frequently used selective analytical steps based on chromatography or immunoaffinity, provide more or less general indirect information. For example, solid-phase extraction (SPE) cleanup followed by liquid chromatography/ultraviolet detection (LC/UV) has been suggested for screening and quantification of ivermectin residues in liver, but presumptive positive samples can be confirmed by derivatizing an aliquot of the SPE eluate and reanalyzing the fluorescent derivative of ivermectin in an LC-fluorescence system (17). [Pg.768]

Since considerable amounts of potential interfering materials can be extracted along with the polyphenolics, an isolation/purification step is often required to eliminate components that may interfere with analysis. The fractionation techniques presented in Basic Protocol 2 and Alternate Protocol 2, using solid-phase extraction to minimize the effects of sample preparation/cleanup on the integrity of the extract, will make possible the identification and quantification of individual polyphenolics by HPLC (unit ii j), MS, and NMR. [Pg.1247]

Table 9 Limits of quantification for PFAs based on ion-pairing and solid-phase extraction methods ... Table 9 Limits of quantification for PFAs based on ion-pairing and solid-phase extraction methods ...
Orlando and Bonato [73] presented a practical and selective HPLC method for the separation and quantification of omeprazole enantiomers in human plasma. Ci8 solid-phase extraction cartridges were used to extract the enantiomers from plasma samples and the chiral separation was carried out on a Chiralpak AD column protected with a CN guard column, using ethanol-hexane (70 30) as the mobile phase, at a flow-rate of 0.5 ml/min. The detection was carried out at 302 nm. The method is linear in the range of 10-1000 ng/ml for each enantiomer, with a quantification limit of 5 ng/ml. Precision and accuracy, demonstrated by within-day and between-day assays, were lower than 10%. [Pg.219]

Louchouarn, P., Opsahl, S., and Benner, R. (2000). Isolation and quantification of dissolved lignin from natural waters using solid-phase extraction and GC/MS. Anal. Chem. 72, 2780-2787. [Pg.446]

Previous applications of ESI-MS could quantify intact proteins at relatively high concentrations, such as that of human transferrin in plasma samples [79] and o ,-globulin in urine and kidney samples [80]. With the use of solid-phase extraction combined with a high-sensitivity MS, improvements on sensitivity were achieved, for example for the quantification of rk5 in monkey plasma reaching a LLOQ of 10.29 ng/mL [81]. [Pg.174]

Marin, J.M., J.V. Sancho, O.J. Pozo, F.J. Lopez, and F. Hernandez. 2006. Quantification and confirmation of anionic, cationic and neutral pesticides and transformation products in water by on-line solid phase extraction-liquid chromatography-tandem mass spectrometry. J. Chromatogr. A 1133 204-214. [Pg.470]

The other form of on-line solid-phase extraction procedures involves column-switching techniques. Column switching employs valves that can be switched manually or automatically between a number of columns at predetermined times.67-69 For sample cleanup the analyte of interest is retained on the primary or precolumn while the interfering matrix components are eluted to waste. The analytes are then diverted to a second or analytical column where they are separated for identification and quantification. [Pg.116]

LLE liquid-liquid extraction, SPE solid phase extraction, LPME liquid-phase microextraction, ESI electrospray ionization, APCI atmospheric pressure chemical ionization, SSI sonic spray ionization, Q quadrupole, QqQ triple quadrupole, TOF time-of-flight, IT ion trap, IS internal standard, CV coefficient of variation, MRE mean relative error, LOD limit of detection, LLOQ lower limit of quantification... [Pg.159]

Badawi N, Simonsen KW, Steentoft A, Bernhoft IM, Linnet K (2009) Simultaneous screening and quantification of 29 drugs of abuse in oral fluid by solid-phase extraction and... [Pg.395]

A methodological approach for an effective and reliable quality control of Chinese star anise [I. verum Hook. F.) was developed and validated by Lederer et al. (2006). A combined method of TLC and HPLC-MS/MS was used for differentiation ofvarious Ulicium species, especially Chinese and Japanese star anise. Species can be distinguished by their TLC flavonoid pattern. A sensitive and selective HPLC/ESI-MS/MS method was developed for the detection and quantification of lower admixtures of I. anisatum and of further toxic Ulicium species at a low concentration range using the sesquiterpene, lactone anisatin, as a marker. This assay includes a solid-phase extraction clean-up procedure with a high recovery (> 90%). [Pg.327]

Bakhtiar R, Khemani L, Hayes M et al. (2002) Quantification of the anti-leukemia drug ST1571 (Gleevec) and ist metabolite (CGP 74588) in monkey plasma using a semi-automated solid phase extraction procedure and liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal 28(6) 1183-1194... [Pg.605]

Simultaneous Quantification of Flunitrazepam (Rohypnol) and its Major Metabolites in Human Plasma by Solid Phase Extraction and High-Performance Liquid Chromatography Atmospheric Pressure Chemical Ionization Tandem Mass Spectrometry, Using Deuterium Labeled Flunitrazepam as Internal Standard... [Pg.618]

Like the hydrolysis methods, many extraction procedures have been described. Table 3 presents the various procedures and the compounds used as IS. With the development of the technology and the introduction of gas chromatography coupled with mass spectrometry (GC/MS), deuterated IS have been used for the quantification of cannabis in hair. Presently, this technique represents the state of the art. Most authors use liquid-liquid extraction only Moeller and Moeller et al. - have reported solid-phase extraction (SPE) procedures. [Pg.183]

Lefebvre, I. et al. Quantification of zidovudine and its monophosphate in cell extracts by on-line solid-phase extraction coupled to liquid chromatography. J. Chromatog. B. 2007, 858, 2-7. [Pg.177]

Kuhnle, G. Dell Aquila, C. Low, Y. Kussmaul, M. Bingham, S. 2007. Extraction and quantification of phytoestrogens in foods using automated solid-phase extraction and LC/MS/MS. Anal. Chem. 79 9234-9239. [Pg.63]


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See also in sourсe #XX -- [ Pg.455 , Pg.461 ]




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