SLN

Representation of Chemical Compounds 29 Table 2-3. Basic SLN syntax without description of attributes and macro atoms. 

SLN is easy to learn and its use is intuitive. The language uses only six basic components to specify chemical structures. Four of them are hsted in Table 2-3 and can be compared directly with the SMILES notation of Section 2,3.3. 

Besides specifications on atoms, bonds, branches, and ring closure, SLN additionally provides information on attributes of atoms and bonds, such as charge or stereochemistry. These are also indicated in square [ ] or angle < > brackets behind the entity e.g., trans-butane CH3CH=[s=t]CHCH3). Furthermore, macro atoms allow the shorthand specification of groups of atoms such as amino adds, e.g., Ala, Protein2, etc. A detailed description of these specifications and also specifications for 2D substructure queries or combinatorial libraries can be found in the literature [26]. 

U(CsMe5)2(SlN=CHCH=CH)a, 2, 78 UC24H16a2N402 U02Cl2(phen)2, 3,1190 UC24H16C15N40 [UOCl5(phen)2]2-,3,1179 UC24H14N4Os... 

For patients with melanomas that are at risk of spreading to the lymph nodes, a sentinel lymph node (SLN) biopsy is performed. The SLN, the first lymph node to receive lymph draining from the tumor, is identified by injecting a radioactive material, technetium-99m-labeled radiocolloids, and vital... 

KM underwent surgical resection of the primary tumor, and an SLN biopsy was positive for lymph node involvement. A lymphadenectomy was performed. After extensive discussion with his oncologist, the decision was made to start KM on interferon-oc2b. 

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