Ascorbic acid tablets

Rutin, Ascorbic acid Tablet MLR Non-destructive quantitation method. Errors (SEP) less than 0.7%. Method validated using ICH-adapted guidelines 129... 

Asker AF, Harris CW. Influence of storage under tropical conditions on the stability and dissolution of ascorbic acid tablets. Drug Dev Ind Pharm 1990 16 165. 

A combination of 4% polyethylene glycol (PEG) 6000 and 0.1% sodium stearyl fumarate proved to be a good lubricant for ascorbic acid tablets made by direct compression on a small scale. Sodium chloride, sodium acetate, and D,L-leucine (water-soluble lubricants) also have been suggested for effervescent tablets. ... 

EBMUD, Oakland, CA Combined chlorine Sodium sulfite Sodium thiosulfate Ascorbic acid Tablets from 2 companies Crystals Powder Varied from 1 to 36 tablets 1 lb in nylon bags placed on the flow path 1.2 8.0 Surface water 100-500 100 100... 

Povidone K 25 and povidone K 30 are very good binders for effervescent tablets, as they dissolve rapidly in water to form a clear solution. This particularly applies to effervescent vitamin tablets, e.g. ascorbic acid tablets [368 b]. Tables 65 and 66 give formulations for ranitidine effervescent tablets and multivitamin effervescent tablets as typical examples that were developed on a laboratory scale. For the granulation of multivitamin preparations, it is always preferable to use a fluidized bed. 

Table 70. Ascorbic acid tablets from compacted powder with povidone K 30 [367]...

Table 174. Dry binding effect of different dry binders in ascorbic acid tablets...

Fig. 3 shows the difference that can occur when ascorbic acid tablets of the same composition are produced at the same pressure, but when the active substance consists of crystals of two different sizes (crystalline =... 

Vemuri S, Taracatac C, Skluzacek R. Color stability of ascorbic acid tablets measured by a tristimulus colorimeter. Drug Dev Ind Pharm 1985 11 207-222. 

Ascorbic acid samples as well as binary mixtures of ascorbic acid and the considered excipients were investigated. The binary mixtures were prepared taking into account the shoichiometry generally used for the preparation of ascorbic acid tablets ascorbic acid (500 mg, of a 100 mesh sample), magnesium stearate (6.7 mg), magnesium trisilicate (13.3 mg), and Si02 (1.0mg). The compounds were mixed in a mortar. 

Based on the TG and DSC experimental results it can be concluded that the excipients, that is, magnesium stearate, magnesium trisilicate, and Si02, have no substantial influences on the thermal stabihty of ascorbic acid. This result shows that the three compounds can be used (at least from a thermal point of view) as excipients, with no restrictions, for ascorbic acid tablet formulations, since they will not provoke or accelerate the thermal degradation of ascorbic acid. However, by comparison of Tables 3.5 and 3.7, it is evident that the temperature of the... 

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