Sodium fusidate

Sodium fusidate (Fucidin) allergy has been reported twice (Dave and Main 1973). 

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Sodium fusidate gauze Medicated open wound ... 

Various antibiotics bacitracin chloramphenicol colistimethate sodium fosfomycin tromethamine fusidic acid metronidazole polymyxin B sulfate rifabutin sodium fusidate... 

Lecithin (phosphatidylcholine) is a phospholipid, which may be isolated from either egg yolk or soybeans. It is commercially available in high purity for medical uses and has been used to enhance the absorption of insulin in vivo [26]. The antibiotic sodium fusidate, a steroid similar in molecular structure to bile salts has also been shown to have permeation enhancing properties for insulin in vitro [41]. 

White, D.G., Collins, P.O., and Rowsell, R.B., Topical antibiotics in the treatment of superficial skin infections in general practice — a comparison of mupirocin with sodium fusidate. J. Infect. 18, 221-229, 1989. 

Infra-red Spectrum. Principal peaks at wavenumbers 1267,1547, 1706, 1238, 1020, 966 (sodium fusidate, KBr disk). 

Oxytetracycline Hydrochloride 538.7 Sodium Fusidate 606.1 Prochlorperazine Maleate... 

Other drugs that act by inhibiting protein synthesis include quinupristin-dalfopristin, linezolid, chloramphenicol and sodium fusidate. 

Uses. Sodium fusidate is a valuable drug for treating severe staphylococcal infections, including osteomyelitis and is available as i.v. and oral preparations. In an ointment or gel, sodium fusidate is used topically for staphylococcal skin infection and as a cream is applied to eradicate the staphylococcal nasal carrier state. Another gel preparation is used for topical application to the eye this contains such a high fusidic acid concentration that it possesses useful activity against most bacteria that cause conjunctivitis, not only staphylococci. 

Pneumonia following influenza is often caused by Staphylococcus aureus, and best guess therapy is usually achieved by adding flucloxacillin to one of the regimens above. When staphylococcal pneumonia is proven, sodium fusidate p.o. plus flucloxacillin i.v. should be used in combination. 

Staphylococcus aureus flucloxacillin 2 g 4-hourly by i.v. injection for at least 4 weeks plus either gentamicin by i.v. injection or sodium fusidate by mouth for the first 1-2 weeks. 

Bile salts sodium deoxycholate sodium glycocholate sodium fusidate sodium taurodihydrofusidate denaturation of proteins decrease of mucus viscosity decrease of peptidase activity solubilization of peptides formation of reversed micelles... 

Povidone iodine 10%, chlorhexidine 0.5%w/w, sodium fusidate 2%w/w, and 1% framycetin sulfate are examples of available gauze impregnations and are recommended for the reduction of wound infection. However, diffusion of fhe anfibacferial agent into or onto an infected and exuding wound has been shown to be minimal and the possibility of development of resistant strains of infective organisms has reduced the usage of these products. 

Sensitization to sodium fusidate is rare, and most often found in patients with stasis dermatitis or atopic dermatitis. 

Lee AY, Joo FIJ, Oh JG, Kim YG. Allergic contact dermatitis from sodium fusidate with no underlying dermatosis. Contact Dermatitis 2000 42(1) 53. 

Table 10.6 The effect of colestyramine administration on sodium fusidate levels"...

Sodium salt, Cj,H17NaO, sodium fusidate, ZN 6, Fucidin, Fucidina, Fucidine, Fucidin Intertulle, Crystals,, sol in wa -ter, LDj(, in mice (g/kg) 0.2 i.v. (Godtfredsen, Nature... 

In vitro studies have shown that colestyramine can bind with sodium fusidate in the gut, thereby reducing its activity, and in vivo animal studies have shown peak fusidate levels are decreased by 33 to 77% by colestyramine, but whether this also occurs clinically has not been confirmed. It is generally recommended that other drugs are given 1 hour before or 4 to 6 hours after colestyramine. 

Johns WH, Bates TR. Drug-cholestyramine interactions. I Physicochemical factors affecting in vitro binding of sodium fusidate to cholestyramine. JPhamiiJd (1972) 61, 730-5. 

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