Cholestyramine drug interactions

A 45-year-old male takes simvastatin for hypercholesterolemia however, his cholesterol level remains above target at maximal doses. Cholestyramine is added to the therapeutic regimen. What drug-drug interaction can occur ... 

The following drug interactions were reported for metronidazole, a chemically related nitroimidazole. Therefore, these drug interactions may occur with tinidazole. Drugs that may affect tinidazole include cholestyramine, CYP3A4 inducers and inhibitors and oxytetracycline. Drugs that may be affected by tinidazole include alcohols, anticoagulants, cyclosporine, tacrolimus, disulfiram, fluorouracil, hydantoins, and lithium. 

Drug Interactions Acyclovir Antacids with magnesium and aluminum hydroxides Cholestyramine Drugs that alter gastrointestinal flora may interact with mycophenolate mofetil by disrupting enterohepatic recirculation Probenecid... 

Drug Interactions Cyclosporine Gemfibrozil Niacin Erythromycin Cholestyramine/Colestipol Warfarin Cimetidine Digoxin ... 

Drug Interactions Gemfibrozil Niacin Erythromycin Cholestyramine Digoxin Cimetidine/ranitidine/ omeprazole Rifampicin Warfarin Itraconazole Gemfibrozil Niacin Erythromycin Propranolol Digoxin Warfarin Antacids Colestipol Digoxin Erythromycin Oral contraceptives Fibrates Niacin Azole antifungals... 

Balmelli N, Domine F, Pfisterer M, Krahenbuhl S, Marsch S. Fatal drug interaction between cholestyramine and phenprocoumon. Eur J Intern Med 2002 13(3) 210-1. 

MYCOPHENOLATE LEFLUNOMIDE T risk of serious infections (sepsis) and of opportunistic infections (Pneumocystis jiroveci pneumonia, tuberculosis, aspergillosis) Additive immunosuppression Monitor platelets, white blood cells, haemoglobin and haematocrit at baseline and regularly - weekly -during concomitant therapy. With evidence of bone marrow suppression, discontinue leflunomide and administer cholestyramine and charcoal to t elimination of leflunomide - For signs and symptoms of immunosuppression, see Qinical Features of Some Adverse Drug Interactions, Immunosuppression and blood dyscrasias... 

Drug Interactions Various drugs can decrease T absorption. Drugs such as aluminum hydroxide, ferrous sulfate, sucralfate, and calcium carbonate should be separated from T administration by 1 to 2 hours. Bile acid sequestrants (cholestyramine and colestipol) must be separated from T by at least 4 hours and preferably 6 hours. CYP450 enzyme inducing drugs such as phenytoin, carba-mazepine, rifampin, and phenobarbital can increase T requirements. 

Because of their mechanism of action, bile acid sequestrants can potentially bind with and decrease the oral absorption of almost any other drug. Because these anion-exchange resins contain numerous positive charges, they are much more likely to bind to acidic compounds than to basic compounds or nonelectrolytes. This is not an absolute, however, because cholestyramine and colestipol have been reported to decrease the oral absorption of propranolol (a base) and the lipid-soluble vitamins. A, D, E, and K (nonelectrolytes). As a result, the current recommendation is that all other oral medication should be administered at least 1 hour before or 4 hours after cholestyramine and colestipol. Interestingly, this drug interaction has been used in a beneficial manner to treat digitalis overdose and toxicity. 

Because finasteride and dutasteride are metabolized primarily by CYP3A4, the CYP3A4 inhibitors, such as ritonavir, ketoconazole, verapamil, diltiazem, cimetidine, and ciprofloxacin, may increase the drugs blood levels and, possibly, cause drug-drug interactions. Clinical drug interaction studies have shown no pharmacokinetic or pharmacodynamic interactions between dutasteride and tamsulosin or terazosin, warfarin, digoxin, and cholestyramine. 

Tembo AV, Bates TR Impairment by cholestyramine of dicumarol and tromexan absorption in rats a potential drug interaction. /P/tamaco/Ther 974) 191,53-9. 

Drug interactions anticonvulsants (phenytoin, barbiturates, carbamazepine) increase the risk of hepatotoxicity by increasing conversion of acetaminophen to toxic metabolites. Isoniazide also increases risk of acetaminophen hepatotoxicity. Acetaminophen may enhance the anticoagulant effect of warfarin with daily doses > 1.3 g for > 1 week. Phenothiazines may increase risk of severe hypothermia with acetaminophen. Cholestyramine resin may decrease the absorption of acetaminophen. 

Drugs that may interact with raloxifene include ampicillin and cholestyramine. Raloxifene may affect warfarin. 

Drugs that may affect amiodarone include hydantoins, cholestyramine, fluoroquinolones, rifamycins, ritonavir, and cimetidine. Drugs that may be affected by amiodarone include anticoagulants, beta-blockers, calcium channel blockers, cyclosporine, dextromethorphan, digoxin, disopyramide, fentanyl, flecainide, hydantoins, lidocaine, methotrexate, procainamide, quinidine, and theophylline. Drug/Lab test interactions Amiodarone alters the results of thyroid function tests, causing an increase in serum T4 and serum reverse T3 levels and a decline in... 

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