Sodium 2- amino phenylacetate

Diclofenac Diclofenac, 2-[(2,6-dichlorophenyl)-amino]-phenylacetic acid (3.2.42), is synthesized from 2-chIorobenzoic acid and 2,6-dichloroaniline. The reaction of these in the presence of sodium hydroxide and copper gives iV-(2,6-dichlorophenyl)anthranyIic acid (3.2.38), the carboxylic group of which undergoes reduction by lithium aluminum hydride. The resulting 2-[(2,6-dicholorphenyl)-amino]-benzyl alcohol (3.2.39) undergoes further chlorination by thionyl chloride into 2-[(2,6-dichlorophenyl)-amino]-ben-zylchloride (3.2.40) and further, upon reaction with sodium cyanide converts into... 

Benzyl bromoacetate Sodium 2-[(2,6-dichlorphenyl)amino]phenylacetate Palladium on carbon Hydrogen... 

Recently, Smulik and Vedejs have reported that sodium and potassium salts of phenylacetates, phenylacetonitriles, malonates and / -cyanoesters can be converted to their a-amino derivatives in good yields using 4a and 4b as amination reagents (Scheme 45) . Amination can be accomplished at lower temperature using 4b. 

All enteral feeds were stopped. The baby was given intravenous glucose, L-arginine, sodium benzoate, and sodium phenylacetate. Hemodialysis was initiated. At this time, there were no spontaneous respirations, there was no response to painful stimuli, and brainstem reflexes were absent. The plasma amino acid results revealed a glutamine level of 1500 pmol/L (normal 254-823), and citrulline was undetectable (normal 10-34 pmol/L). Quantitative carnitine, plasma acylcarnitine, and urine organic acid profiles were normal. The urine orotic acid concen-... 

Harada and Matsumoto studied the effect of solvents on the % ee of the amino acids formed in asymmetric transamination.56 Generally, the optical activity of alanine prepared from benzyl pyruvate and (S )-)-)-1-phenylethylamine decreased with increasing polarity of the solvents used. From the finding that sodium a-phenylglycinate was hydrogenolyzed easily to ammonia and phenylacetate over palladium catalyst, Harada prepared optically active alanine, butyrine, glutamic acid, and aspartic acid in 40-60% optical purities from the corresponding a-oxo... 

Treatment involves a low-protein diet (0.5-0.7 g/kg BW/day) with a sufficient supply of calories. Substitution of essential amino acids (in about the same quantity) is required. The administration of benzoate (0.1-0.25 g/kg BW/day), arginine hydrochloride (1 mmol/kg BW/day) or sodium phenylacetate (0.3-0.5 g/ kg BW/day) (phenylbutyrate tends to be more effective) facilitates nitrogen excretion via other metabolic pathways. (168-170) With an enhanced excretion of orotate or other metabolites of pyrimidine synthesis, the administration of allopurinol leads to an increase in the excretion of nitrogen via metabolites from pyrimidine synthesis. Ammonia and urea precursors are eliminated by haemodialysis. In individual cases, liver transplantation is indicated. (I7l)... 

Sodium enolates of ketones and disodium enediolates of substituted phenylacetic acids reacted with activated aziridines to afford 7-amido ketones and 7-amidobutyric acids, respectively (Scheme 72). Aziridine-2-carboxylic acid esters can be utilized as versatile precursors for amino acid derivatives. Although the product distribution resulting from the reaction of activated aziridine-2-carboxylates with amines depends on the structure of the reactants, the reactions with alcohols or thiols in the presence of acidic cabilysts generally gave the a-amino acid derivatives (Scheme 73). ° On the other hand, free 3-methyl-2-aziridinecarboxylic acids (168) reacted with thiophenol, cysteine and glutathione to afford P-amino acid derivatives with sulfur substituents at the a-position as the main product (Scheme 73). ... 

Chiral metal alkoxides are apparently attractive candidates for the asymmetric catalyst since they are readily available. A very low level of asymmetric induction, however, was observed when lithium (S)-l-phenylethoxide was used in the reaction of phenylacetate 41 and acrylate 42. Koga showed that a stoichiometric amount of the hthium alkoxide derived from an amino alcohol promoted the asymmetric addition giving (S)-43 in 84% ee [38]. Use of sodium or potassium salts resulted in racemic 43. A catalytic reaction (10 mol %) still exhibited a selectivity of 41% ee (Scheme 8). 

Amfenac sodium W. A stirred solution of lllg (0.43 mol) of 2-amino-3-benzoyl-phenylacetic acid ( = amfenac) in 111 ml of tetrahydrofuran is treated with 31.3 g (0.39 mol) of 50% NaOH. After cooling the solution at 0°C for 3 h, the solid which precipitates is collected by filtration to yield 64 g (56%) of the expected sodium salt, m.p. 245-252°C. An analytical sample is obtained by dissolving 1.0 g of the crude salt in 10 ml of 95% EtOH and treating the solution with 5 ml of isopropyl ether. The pure sodium salt precipitates slowly to yield 0.9 g of yellow solid, m.p. 254-255.5 C. 

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