Cancer hereditary

Androgens also have been used in the management and treatment of agnogenic myeloid metaplasia, aplastic anemia, breast cancer, hereditary angiodema, osteoporosis, paroxysmal nocturnal hemoglobinuria, and sideroblastic anemia. 

Fearnhead NS, Wilding JL, Bodmer WF. Genetics of colorectal cancer hereditary aspects and overview of colorectal tumorigenesis. Brit Med Bulletin 2002 64 27-43. 

Prostate cancer Hereditary neuropathy with liability... 

KNUDSON A G Jr (1989) The ninth Gordon Hamilton-Fairley memorial lecture. Hereditary cancers clues to mechanisms of carcinogenesis , Br J Cancer, 59, 661-6. 

MSH2, MLH1, PM SI, DNA mismatch repair enzymes Hereditary nonpolyposis colorectal cancer... 

Familial adenomatous polyposis (FAP) and hereditary nonpolyposis colorectal cancer (HNPCC)... 

Non-steroidal anti-inflammatory agents, aspirin, and acetaminophen have been suggested for use in the prevention of different cancers, especially hereditary non-polyposis colon cancer.14 While there have been observational studies linked to a reduction of ovarian carcinoma risk, evidence is still lacking. Potential... 

No known family history of cancer specifically, no NMSC, MM, or hereditary... 

Hedenfalk I et al. Gene expression profiles in hereditary breast cancer. N Engl J Med 2001 344 539-548. 

Sv, adults 1% probability of hereditary effects 4% probability of fatal cancer in occupational workers 13... 

Without regard to therapy, potentially valuable diagnostic tests are available for presymptomatic evaluation of risk of breast cancer due to predisposition from BRCA 1 or BRCA 2 and of colon cancer related to familial adenomatous polyposis (APC gene) or hereditary nonpolyposis mismatch repair genes (MSH 2). Genetic predisposition to Alzheimer disease associated with ApoE4 is neither sufficient nor necessary to lead to the clinical condition, and no definitive therapy is available. 

Stochastic radiation effects are typically associated with those that occur over many months or years (i.e., are typically chronic instead of acute). Chronic doses are typically on the order of background doses (0.3 rem [0.003 Sv] or less) and are not necessarily associated with larger doses that could result from a terrorist attack with radiological weapons. However, stochastic health effects are defined here as effects that occur many years after chronic or acute exposure to radiological contaminants. Stochastic effects are categorized as cancers and hereditary effects. Because no case of hereditary effects (e.g., mutation of future generations) has been documented, this discussion focuses on cancer risk. 

A personal or family history of a genetic condition, birth defect, chromosomal disorder, or hereditary cancer. 

Retinoblastoma An eye cancer that most often occurs in children younger than 5 years. It occurs in hereditary and nonhereditary (sporadic) forms, [nih]... 

J. P., SozEN, M. A., Baron, A., Zeng, C., Frigkson, P. F., Hooper, J. E., Drabkin, H. a. The TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathway. Oncogene 2002, 21, 3507— 3516. 

Mismatched base (Gj) DNA replication errors A mutation on one of two genes, hMSH2 or hMLHl, initiates defective repair of DNA mismatches, resulting in a condition known as hereditary nonpolyposis colorectal cancer— HNPCC. DNA polymerase DNA ligase... 

Hereditary nonpolyposis colorectal cancer results from a deficiency in the ability to repair mismatched base pairs in DNA that are accidentally introduced during replication. 

A second group of inherited colon cancers are termed hereditary nonpolyposis colorectal cancer (HNPCC). HNPCC may account for 5% of all colon cancer cases and can be caused by mutations in any of five different genes. All of these genes encode proteins involved in DNA mismatch repair (Fig II-5-3). As with inherited breast cancer, fiiulty DNA repair leads to mutated cells capable of producing tumors. 

There is a disease termed hereditary polyposis. Victims develop a very large number of polyps in their colons, sometimes several thousand. Since the development of a colon polyp is the first step on the road to colon carcinoma, they are at high risk of colon cancer. The associated mutation is in a gene known as the APC gene. 

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