Skin irritation epoxy resin

Skin. Most epoxy resins are not acutely irritating to the skin. However, they are capable of causing skin sensitization. Susceptibility to skin irritation and sensitization varies from person to person. The epoxy resins are considered to be milder skin sensitizers than amine-type curing agents or epoxy functional reactive diluents. 

Toxicology Toxic by inhalation strong irritant to eyes and skin Uses Epoxy resin curing agent (elec, castings) intermediate for paints, alkyds, plasticizers, insect repellents, rust inhibitors hardener in epoxy resins... 

Solid epoxy resins based on the reaction product of epichlorohydrin and bisphenol A or bisphenol F mild to moderate irritants and mild sensitizers not readily absorbed through skin low volatility, exposure unlikely unless crushed or ground low toxicity... 

Solvents used as nonreactive diluents include acetone, cellosolve, methyl ethyl ketone, methyl isobutyl ketone, methylene chloride, 1,1,1-trichloroethane, toluene, and xylene. Skin and eye irritation and, in higher concentrations, CNS depression and respiratory irritation may result ftom exposure to these solvents as diluents for epoxy resin... 

The curing process renders the resin essentially inert and nontoxic. At room temperature, full curing may take several days incompletely cured resins may cause skin irritation and sensitization. Respiratory symptoms may result from inhalation of cured epoxy dusts during grinding, presumably due to release of residual curing agent. Skin irritation and sensitization have been associated with epoxy resin exposure. 

Diglycidyl ether of bisphenol A (low molecular weight epoxy resins epoxy value ca. 0.57 mol/100 g) 25 g, 0.060 mmol can cause eye and skin irritation... 

Epoxy-amine adducts are produced to provide curing agents that have reduced skin and eye irritation and better flexibility than unmodified amines. These epoxy amines are formed by the reaction of either a primary or secondary amine with an epoxy resin. They are more fully described in Chap. 5. 

Some of the solvents that are commonly used in epoxy resins can present a flammability hazard and special health hazards. Contact with solvents will cause drying of the skin, which may result in an increased probability of skin irritation, especially when one comes in contact with curing agents. Solvents also have the ability to dissolve epoxy resin system components and carry them through the skin in liquid form or into the respiratory system in vapor form. The inhalation of solvent vapors or mist may cause respiratory irritation and... 

Epoxy Resins. Liquid epoxy resins are mild to moderate irritants to the skin, eyes, and mucous membranes. The irritant potential is increased by their sticky nature, which tends to lead to prolonged skin contact. These resins are generally mild to moderate dermal (skin) sensitizers in susceptible individuals. 

Solid epoxy resins are not readily absorbed through the skin and present a low risk of skin irritation. Direct contact with solutions of these resins can cause mild to moderate irritation of the skin and the eyes, principally because the solvents remove the protective layer of fat that is on the surface of the skin. When crushed into a fine powder, epoxies should be considered an irritant dust, and inhalation and skin contact should be avoided. Solid resins are generally considered to be low to mild sensitizers. 

Bis(4-aminophenyl)methane, commonly known as 4,4/-methylenedianiline, or MDI (41), is toxic, with an acute oral LD50 (rat) of approximately 200 mg kg-1. Occupational exposure occurs by inhalation and dermal contact, particularly from its use as an epoxy resin hardener. Excessive exposure to its dust has resulted in temporary liver damage in workmen. It is a mild eye irritant and can cause cyanosis. Though it is not a primary skin irritant or strong sensitizer, skin irritation can occur with sensitive individuals. It can be handled safely if care is taken to prevent excessive exposure to dust and fumes. 

It is sometimes recommended that persons subject to allergy should not be allowed to come in contact with epoxy resin systems. This would be an improbably measure to observe, it must be kept in mind that exposure to epoxy resin systems cannot cause anything but skin dermatitis. There has been absolutely no evidence of any carcinogenic effect from contact with these systems. Where slight irritations occur, desensitization should first be attempted. If eczema occurs, standard medical treatment should be provided. Antihistamine drugs may be used only to reduce itching. In severe cases, such as in the second stage of dermatosis, cortisone ointments have been used successfully to relieve the symptoms. It should be kept in mind that if protective measures are scrupulously observed, incidents of dermatoses from epoxy resin systems can be kept to a very low minimum. There is no reason for any concern in the use of these systems in the construction industry. 

Reactive diluents and low molecular mass aliphatic epoxy resins are of low viscosity, show a noticeable vapor pressure and have to be handled with care. These substances produce medium to strong irritation of skin and mucous membranes they are also sensitizers and can cause skin disorders. 

Properties Colorless-ylsh. clear-sl. muddy liq., hydrocarbon-like odor insol. in water sp.gr. 0.81 (20 C) dens. 6.76 Ib/gal b.p. 235-257 C flash pt. (Seta CC) 95 C ref. index 1.448 5% NV Use Level 0.5-2% on epoxy resin plus hardener Toxicology Inh. of vapors may cause respiratory tract irritation, headaches, nausea, vomiting, CNS depression repeated/prolonged contact may cause eye and skin irritation repeated ingestion may irritate digestive tract TSCA listed... 

Use Level 133 phr with Epoxy Resin EEW190 Toxicology Causes severe skin and eye irritation can cause burns on proionged contact do not breathe vapors Storage Store in cooi, dry piace in tightiy dosed containers prod, wiii absorb moisture and COj which may affect vise, or create foaming with epoxy resins 1 yr min. sheit iite Epikure 3270 [Resoiution Pert. Prods.]... 

Toxicology LD50 (oral, rat) 265 mg/kg, (skin, rabbit) 1660 mg/kg poison by ing. mod. toxic by inh., skin contact corrosive severe skin and eye irritant TSCA listed Precaution Flamm. exposed to heat or flame Hazardous Decomp. Prods. Heated to decomp., emits toxic fumes of NOx Uses Intermediate dehydrohalogenating catalyst corrosion inhibitor acid neutralizer potting compounds adhesives paints cellulose modifier catalyst for rigid PU foam, polyester resins epoxy resin curative, accelerator... 

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