Skin disorders irritant

Adverse Side Effects. Gastric irritation, confusion, sedation, dizziness, headache, cerebellar signs (nystagmus, ataxia, dysarthria), gingival hyperplasia, increased body and facial hair (hirsutism), and skin disorders are typical adverse effects. 

Adverse Effects. The most serious problem associated with chloroquine is the possibility of toxicity to the retina and subsequent visual disturbances. This issue is usually insignificant, however, when this drug is used for short periods in relatively low doses (see Chapter 16). Other relatively mild side effects may occur, including gastrointestinal distress (nausea, vomiting, stomach cramps, diarrhea), behavior and mood changes (irritability, confusion, nervousness, depression), and skin disorders (rashes, itching, discoloration). 

Dactinomycin Cosmegen Carcinoma of testicle and endometrium carcinosarcoma of kidney [Wilms tumor] Ewing sarcoma rhabdomyosarcoma Blood disorders [leukopenia, thrombocytopenia, others] Gl distress [nausea, vomiting, loss of appetite] mucocutaneous lesions skin disorders [rash, hair loss] local irritation at injection site... 

Skin tolerability in patients with a history of eczema, psoriasis, or other skin disorders has been studied in 1481 participants (33). The adverse effects reported were erythema, rash, pruritus, irritation, edema at the site of application, musculoskeletal pain related to the application site, dreaming, and other sleep disturbances. 

ALLERGIC, IRRITANT, AND INFECTION-RELATED SKIN DISORDERS... 

Some active species have been studied and their pharmacological activity confirmed in different experimental models. In general, the active fractions of such plants were those containing cucurbitacins, as demonstrated by Rios et al. [10] in their work with Cayaponia tayuya roots. This species is used in the Amazon region of South America as an analgesic, anti-inflammatory, and anti-rheumatic agent while the extracts of this species are widely employed in the treatment of skin disorders such as dermatosis and other irritations. The chloroform fraction obtained from the active root methanol extract was found to be more active than the ethyl acetate and butanol fractions. Subsequent phytochemical analysis demonstrated that the chloroform fraction is rich in cucurbitacins, whereas the ethyl acetate and butanol fractions are principally comprised of C-glycosil flavonoids [10]. 

ACUTE HEALTH RISKS irritation of nose and throat irritation of gastrointestinal tract irritation to skin, including redness, itching, and pain causes eye irritation, including redness and pain may affect central nervous system drowsiness loss of consciousness persons with pre-existing skin disorders or eye problems, or impaired kidney, liver or respiratory function may be more susceptible to the effects of ethyl formate. 

Pruritus, burning, worsening of clinical signs and symptoms, periungual erythema, nail disorders, irritation, ingrown toenail, burning of the skin... 

Reactive diluents and low molecular mass aliphatic epoxy resins are of low viscosity, show a noticeable vapor pressure and have to be handled with care. These substances produce medium to strong irritation of skin and mucous membranes they are also sensitizers and can cause skin disorders. 

Absorption route Can enter the body by inhalation or ingestion. Immediate effects irritates the eyes, skin and respiratory tract. In serious cases risk of unconsciousness. Effects of prolonged/repeated exposure Can affect the blood if ingested. Prolonged or repeated contact can cause skin disorders (eczema). ... 

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