Gastrointestinal tract irritability

Adverse reactions associated with probenecid therapy include occasional rashes, allergic dermatitis, upper gastrointestinal tract irritation, and drowsiness. The drug is contraindicated in patients with a history of renal calculi. 

PVAP Gastrointestinal tract irritation in rat and dog and embryo toxicity in rat and rabbit Very high-dose effects only following oral administration 42... 

DOT CLASSIFICATION 5.1 Label Oxidizer SAFETY PROFILE Moderately toxic by ingestion. Human systemic effects by ingestion ulceration or bleeding from stomach. Autopsy findings include gastrointestinal tract irritation, tissue edema, liver and kidney congestion. A severe eye and skin irritant. When heated to decomposition it emits chlorides and carbon monoxide. 

The potential for esophageal or gastrointestinal tract irritation following ingestion suggests that emesis should not be induced. Other measures to prevent absorption may be beneficial. Exposed skin and eyes should be copiously flushed. Liver function and blood glucose must be monitored. 

Induced emesis is not recommended if the victim has any signs of esophageal or gastrointestinal tract irritation or burns, or decreased sensory response, depressed gag reflex, or impending shock. Activated charcoal slurry with or without saline cathartic or sorbitol can be given in cases of oral exposures. Skin decontamination should be done with repeated washing with soap. Exposed eyes should be irrigated with copious amounts of room-temperature water... 

Vomiting and gastrointestinal tract irritation have been seen with quinones. Nonspecific liver changes... 

An acute oral MRL for formaldehyde was not derived because data describing dose-response relationships for gastrointestinal tract irritation in humans or animals after acute oral exposure are lacking. The reports of gastrointestinal effects and symptoms in humans who ingested single large doses (>200 mg/kg) of formaldehyde (Burkhart et al. 1990 Eells et al. 1981 Kochhar et al. 1986), coupled... 

Vanillin is considered safe for human consumption, although it can be toxic in very large quantities. Known reactions include respiratory irritation, including coughing and shortness of breath, and gastrointestinal tract irritation. Contact with the skin or eyes can also cause irritation, redness, and pain. These symptoms are virtually unknown except for individuals who work directly with the pure compounds. 

HEALTH SYMPTOMS inhalation (headaches, dizziness, cyanosis) skin absorption (RBC Heinz bodies) ingestion (esophageal or gastrointestinal tract irritation). 

ACUTE HEALTH RISKS irritation of nose and throat irritation of gastrointestinal tract irritation to skin, including redness, itching, and pain causes eye irritation, including redness and pain may affect central nervous system drowsiness loss of consciousness persons with pre-existing skin disorders or eye problems, or impaired kidney, liver or respiratory function may be more susceptible to the effects of ethyl formate. 

ACUTE HEALTH RISKS irritation of eyes emd mucous membranes respiratory tract irritation dyspnea bronchopneumonia pulmonary edema irritation of the nasal mucosa and rhinorrhea irritation of the throat conjunctivitis can induce methemoglobinemia in humans, which may lead to cyanosis central nervous system depressant esophageal or gastrointestinal tract irritation or bums may develop fatty degeneration of the liver and kidneys human fatalities have occurred from acute exposure. 

I. Mechanism of toxicity. Inhaled Cd is at least 60 times more toxic than the ingested form. Fumes and dust may cause delayed chemical pneumonitis and resultant pulmonary edema and hemorrhage. Ingested Cd is a gastrointestinal tract irritant. Once absorbed, Cd is bound to metallothionein and filtered by the kidney, where renal tubule damage may occur. 

IV. Diagnosis is based on a history of exposure and evidence of mucous membrane, respiratory, or gastrointestinal tract irritation. 

Emetine is a gastrointestinal tract irritant causing reflex increase in respiratory secretions. It acts as an emetic in higher doses, and is indicated in chronic bronchitis and whooping cough. 

These NSAIDs are photolabUe and are known to exhibit phototoxicity, causing a number of side effects such as dizziness, drowsiness, nausea, and gastrointestinal tract irritation. Many of them can also induce skin photosensitivity in some patients. In addition, ketoprofen, one of the commonly prescribed NSAIDs, produces photohemolytic activity toward red blood cells and is also capable of causing photocleavage of DNA. - The photosensitization of NSAIDs can be traced to their photochemistry and, upon excitation, decarboxylation is the major reaction pathway. " The aryl methyl radical can then react with molecular oxygen to yield a peroxide radical. It can also undergo coupling and other related radical reactions. 

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