Nail disorders

Docetaxel Myelosuppression, severe fluid retention Alopecia, fatigue, stomatitis, nausea, vomiting, diarrhea, peripheral neuropathy, nail disorder, skin reactions, hypersensitivity reactions... 

Docetaxel Neutropenia (DLT), hyperlacrimation, fluid retention, nail disorders, myelosuppression Use with caution in liver dysfunction. Do not give if biliary tract is obstructed. Premedicate dexamethasone. 

Krebs A. 1983. [Drug induced nail disorders], Deutsch Apotheker Zeitung 123 557-561. (German). 

Skin and subcutaneous tissue disorders Reversible cutaneous reactions have been observed and are generally mild to moderate. Reactions are characterised by a rash including localised eruptions mainly on the feet and hands (including severe hand and foot syndrome), but also on the arms, face or thorax, and frequently associated with pruritus. Eruptions generally occur within one week after the docetaxel infusion. Severe nail disorders are characterised by hypo- or hyperpigmentation and sometimes pain and onycholysis. 

Midgley G, Moore MK, Cook J, Phan QG Mycology of nail disorders. J Am Acad Dermatol 1994 31 S68-S74. 

Norton LA. Nail disorders. A review. J Am Acad Dermatol 1980 2(6) 451-67. 

Onycholysis, the painless separation of the nail plate from the nail bed, is one of the most common nail disorders. 

Myelosuppression fluid retention syndrome edema, weight gain, pleural effusions, ascites typically occurs when cumulative dose exceeds 400 mg/m alopecia rash forearms, hands nail disorders onycholysis, banding, hypo- or hyperpigmentation mild peripheral neuropathy mildly emetogen hypersensitivity reactions... 

Pruritus, burning, worsening of clinical signs and symptoms, periungual erythema, nail disorders, irritation, ingrown toenail, burning of the skin... 

The main goals when handling occupational nail disorders are (1) long-term management and (2) prevention. Management must take into account the... 

Fisher AA, Baran R (1992) Occupational nail disorders with a reference to Koebner s phenomenon. Am J Contact Dermat 3 404-406... 

Occupational nail disorders are reviewed in Chap. 31 and hair loss in Chap. 32. 

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