Skeletal deformation

Tb allium intoxication during the first trimester of pregnancy can cause skeletal deformities, alopecia, rash, low birth weight, and premature birth (38). 

IMPAIRED PHYSICAL MOBILITY. The patient may have an acute or chronic disorder with varying degrees of mobility. The patient may be in acute pain or have longstanding mild to moderate pain. Along with the pain there may be skeletal deformities, such as the joint deformities seen with advanced rheumatoid arthritis. Considering the nature of the patient s condition, the nurse s assistance with ambulation may be required. The nurse determines the degree of immobility of the patient and assists the patient as needed. 

Farber s disease Ceramidase Acyl-i-Sphingosine Ceramide Hoarseness, dermatitis, skeletal deformation, mental retardation fatal in early life. 

Figure 9.12. Potential energy profile along (adapted from reference 10) near the fulvene conical intersection. The branching space consists of stretching and skeletal deformation of the five-membered ring.

Figure 9.25. A cartoon showing the lowest K-K excited states along a proton transfer coordinate and a skeletal deformation coordinate from the branching space (adapted from Figure 4 of reference 16).

Patients with end-stage renal disease hyperphosphatemia ineffectively filter excess phosphate that enters the body in the normal diet.278 Elevated phosphate produces the bone disorder renal osteodystrophy. Skeletal deformity may occur, possibly associated with cardiovascular disease. Calcium deposits may further build up around the body and in blood vessels creating further health risks. The use of lanthanum carbonate is being promoted as an alternative to aluminum-based therapies.279,280 Systemic absorption, and cost have produced a clinical candidate, Fosrenol (AnorMED), an intriguing use of a lanthanide compound in therapy. 

BMPs. Consistent with this surmise is the finding that CBP knockout mice show reduced Bmp7 expression and skeletal deformities (Tanaka et al, 1997). 

Osteogenesis imperfecta Mutations in collagen genes Skeletal deformities Fractures, blue sclera... 

Hemorrhagic disease with no connective tissue problems Gum hyperplasia, inflammation, loss of teeth Skeletal deformity in children foot wound healing Anemia... 

Yovo et al. stated that these alkaloids act via inhibition of ganglionic impulse transmissions of the sympathetic nervous system. It is evident that each alkaloid has its own effect. Anagyrine caused skeletal deformity in foetuses when pregnant cows consumed toxic lupines . On the other hand, some quinolizidine alkaloids are used as a drug in folk medicine". They probably have chronic toxicity. However, adequate knowledge about the chronic toxicity of these alkaloids and especially of chronic toxication across generations is not available. The premise that quinolizidine alkaloids have not produced hereditary symptoms has not been checked with total reliability. 

Clinical manifestations may occur in virtually every organ system, with widely variable progression often involving short stature, skeletal deformities, intestinal abnormalities, spasticity, joint stiffness,... 

The disease is usually diagnosed by adolescence, and patients exhibit tall stature and a variety of skeletal deformities, inciuding very iong, thin bones of the digits and iimbs fiat feet scoiiosis and breastbone deformation. 

Skeletal fluorosis can be defined as excessive deposition of fluoride in bone. This is a pathological condition that is by far the most important aspect of chronic exposure to elevated levels of fluoride, either by inhalation or by ingestion. The skeletal deformities may be associated with or accentuated by nutritional deficiencies or even malnutrition and hard manual work or, possibly, other conditions found in areas of long-term social and nutritional deprivation [6]. See, for instance Fig. 1 of [54]. The situation is specific also for populations consuming large volumes of water, such as athletes or people with certain medical conditions or... 

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