Drugs prediction

Avdeef, A., Artursson, P., NeuhofF, S., Lazorova, L., Grasjo, J., Tavelin, S. Caco-2 permeability of weakly basic drugs predicted with the double-sink PAM PA pKl method. Eur.J. Pharm. Sci. 2005, 24, 333-349. 

From an acid-base titration curve, we can deduce the quantities and pK.d values of acidic and basic substances in a mixture. In medicinal chemistry, the pATa and lipophilicity of a candidate drug predict how easily it will cross cell membranes. We saw in Chapter 10 that from pKa and pH, we can compute the charge of a polyprotic acid. Usually, the more highly charged a drug, the harder it is to cross a cell membrane. In this chapter, we learn how to predict the shapes of titration curves and how to find end points with electrodes or indicators. 

Boccardi G. Autoxidation of drugs prediction of degradation impurities from results of reaction with radical chain initiators. II Farmaco 1994 49(16) 431-435. 

Mahmood I. Interspecies scahng of protein drugs prediction of clearance from animals to humans. J Pharm Sci 2004 93(l) 177-85. 

Greenhill, J.V. Is the photodecomposition of drugs predictable In Photostability of Drugs and Drug Formulations Tpnnesen, H.H., Ed. Taylor Francis London, 1996 83-110. 

Higuchi, T. and Davis, S.S. (1970). Thermodynamic Analysis of Structure-Activity Relationships of Drugs Prediction of Optimal Structure. J.Pharm.ScL, 59,1376-1383. 

If the patient with coronary artery disease also develops cardiac dysfunction, the same medications would be expected to apply, but for additional reasons. The re-instation of preconditioning mechanisms by ACEI administration has already been described. (I-blockers have additional mechanisms, such as an antiapoptotic and antioxidant action.276 In this situation oxidative stress is also predominant and may further exacerbate apoptotic mechanisms.277 The only drugs predictably diminishing oxidative stress in clinical usage are carvedilol and statins. The latter drug family is also used in heart failure. Exercise is also a standard preventive and therapeutic intervention in both the above categories. 

Figure 9.6 Human in vivo permeability is one of as the absorption parameter has several the cornerstones ofthe BCS. Correlation ofthese important advantages. First, it is possible to measurements with fraction dose absorbed and measure Pefrregardless oftransport mechanism permeability values from other permeability (s) across the intestinal mucosa, and second, it models make it feasible to classify drugs predicts Fa and can be used to assess in vitro-in...

Ganser GH. A rational approach to drug prediction of spherical and non-spherical particles. Powder Technol 1993 77 143-152. 

Which one of the following drugs predictably prolongs the PR interval and increases cardiac contractility ... 

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