Local similarity

Simons KT, Kooperberg C, Huang E, Baker D. Assembly of protein tertiary structures from fragments with similar local sequences using simulated annealing and Bayesian scoring functions. J Mol Biol 1997 268 209-25. 

Several topically applied local anesthetics are routinely used by the eye care specialist in certain routine diagnostic procedures and for various relatively simple surgical procedures such as insertion of punctal plugs and surgical vision correction. The first of these to be used was cocaine, in concentrations ranging from 1 to 4% [30]. More modern local anesthetics, however, such as tetracaine hydrochloride and proparacaine hydrochloride, have replaced cocaine as drugs of choice in these procedures. For surgical procedures of a more complex nature, lidocaine hydrochloride and similar local anesthetics as retrobulbar injections have been used [31]. 

Electrons in the core of an atom are fully localized into spherical shells but not into opposite-spin pairs. In an isolated atom the valence shell electrons are similarly localized into a spherical shell. The Laplacian shows that in each of these spherical shells there is a spherical region of charge concentration and a spherical region of charge depletion. But in these regions there is no localization of electrons of opposite spin into pairs. There are no Lewis pairs or electron pair domains in an inner shell. The domain of each electron is spherical and fully delocalized through the shell. 

Similar results were obtained in cats. Intraperitoneal injections of the Hi receptor antagonist mepyramine (1 and 5 mg/kg) dose-dependently increased NREM sleep and decreased wakefulness, REM sleep, and the latency to sleep within 1 h of injection (Lin et al., 1988). Similarly, local application of mepyramine (120 pg in 1 pi) into the TMN region increased NREM sleep, with a concomitant decrease in wakefulness within 1 h of injection. However, unlike the systemic injection, the latency to sleep remained unchanged and REM sleep was significantly increased following local injection of mepyramine in the TMN region (Lin et al., 1988). 

There is doubtful statistical significance in the trend observed in the bondlengths. However, it appears that the similarity in the data for the samples is indicative of similar local structure at all stages of polymer deposition. These values correlate very well with the known coordination number of six and a Ru-N distance of 2.056 A. Q4)... 

Flypersensitivity to trimethobenzamide, benzocaine or similar local anesthetics parenteral use in children suppositories in premature infants or neonates. 

Contraindications Hypersensitivity to benzocaine or similar local anesthetics... 

Vapor Density (vap d). This value expresses the ratio of the density/of a vapor to the density of air. The vapors of most flammable liquids are heavier than air, thus they can readily flow into low areas, excavations and similar localities. Hence, ventilating outlets in a plant should be located near ground level. 

Similar local effects may be produced by injecting histamine liberators (compound 48/80, morphine, etc) intradermally or by applying the appropriate antigens to the skin of a sensitized person. Although most of these local effects can be prevented by adequate doses of an H -receptor-blocking agent, H2 and H3 receptors may also be involved. 

In essence, jSel is the interaction between the electronic wave functions of A and B. Obviously there must be some spatial overlap between the two in order to give rise to a finite value. Furthermore, if 0A. and />B fall in the same symmetry class or, in complex molecules, have similar local symmetry, the value of j8 may be relatively large. This will depend upon whether or not the perturbation operators, H, have preferred symmetry properties. The Woodward-Hoffman rules suggest that these operators can... 

The amidoxy, or ip[C0-NH-0], link 6 (R1 = H) results from N-acylation of an a-aminoxy acid. a-Aminoxy acids have been isolated from natural sources and some of them present antibacterial properties as such, or when coupled to an a-amino acid, as in malioxamycin H-L-Vali )[C0-NH-0]D-Asp-0Hj115 117l The a-aminoxy acids are homologous to the a-hy-drazino acids with the advantage that there is no problem of regioselectivity for N-acylation. Despite the easy preparation of a-aminoxy acids,1118-1201 the number of (amidoxy) peptides reported in the literature is rather limited, with no examples of solid-phase synthesis. Recently, it has been observed that the a-aminoxy and a-hydrazino acid units induce quite similar local folded structures.1 21-123 ... 

Regarding the photoionization of predominantly ligand MOs, many authors proceed on the assumption that there is a crude relationship between spectral intensity and orbital degeneracy. This assumption should be viewed with caution, however, since the generalization is accurate only for the ionization of electrons with similar localization properties. 

A third role of natural products is their utility as prototypes or models for synthetic drugs possessing physiological activities similar to the original drug. Procaine and similar local anesthetics are commonly cited representatives of this category. 

The right panel of Fig. 9 shows the surface state of dzi ri character observed in Cr(100) right at the Fermi level [59], Many bcc surfaces posses a similar localized surface state in W(100) it has been found close to the Fermi level (—0.3eV) [63], as in Mo(100) [65] (— 0.2eV). 

Figure 33. Hydration correlation functions c(t) probed by W31 in hTrx and two mutants in reduced states. The three functions are strikingly similar, indicating a similar local solvent environment upon mutation. The inset shows the fluorescence anisotropy dynamics of W31. The nearly constant r(t) reflects a very rigid local structure.

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