Proteins signal transduction

Beside other functions in signal transduction, protein inhibitors of activated STAT suppress the DNA-binding activity of STAT proteins. 

Mikalsen T, Gerits N, Moens U (2006) Inhibitors of signal transduction protein kinases as targets for cancer therapy. Biotechnol Annu Rev 16 153-223... 

Table 2 Signal Transduction Proteins as Potential Therapeutic Targets... 

These are considered to be functionally competent protein domains owing to their ability to maintain their structure and molecular recognition properties independent of the full-length protein (Cohen GB, Ren R, Baltimore D. Modular binding domains in signal transduction proteins. Cell 1995 80 237-248). 

IN PROTEIN COMPLEXES TOGETHER WITH OTHER SIGNAL-TRANSDUCTION PROTEINS... 

Bastiaens, P. I. and Jovin, T. M. (1996). Microspectroscopic imaging tracks the intracellular processing of a signal transduction protein fluorescent-labeled protein kinase C beta I. Proc. Natl. Acad. Sci. USA 93, 8407-12. 

SH2 domains generally consist of approximately 100 amino acid residues [49,50, 60,61 ] and have been first identified as a conserved sequence region between the oncoproteins Src and Fps [19, 48]. By means of sequence homology, SH2 domains have been uncovered in numerous other intracellular signal transduction proteins (Figs. 1 and 4) [20]. 

Signal-to-noise (S/N) ratio FTIR system, 24 115 in rapid scanning instruments, 24 228 Signal transduction proteins, 20 832 Signal transmission, in process control, 20 684... 

In contrast to the receptors for insulin and growth factors (see p. 388), the cytokine receptors (with a few exceptions) have no tyrosine kinase activity. After binding of cytokine (1), they associate with one another to form homodimers, join together with other signal transduction proteins (STPs) to form dimers, or promote dimerization of other... 

C. Receptor, Protease, and Signal Transduction-Protein Targets... 

C. Peptidomimetics Signal-Transduction Protein Inhibitors and Antagonists... 

An example of the signal-transduction protein-targeted inhibitor design which illustrates both peptide scaffold- and nonpeptide template-based approaches is that for the Ras famesyl transferase inhibitor discovery. Such compounds show potential as new therapeutic agents for Ras-related carcinogenesis [81]. Substrate sequences for famesyl transferase have the consensus Cy s-A A, - A A2-Met motif (AA refers to Val or lie). Both substrate-based... 

Signal-transduction protein-targeted peptidomimetics derived by structure-based drug design... 

Nagasawa, S. Tokishita, S. Aiba, H. Mizuno, T. A novel sensor-regulator protein that belongs to the homologous family of signal-transduction proteins involved in adaptive responses in Escherichia coli. Mol. Microbiol., 6, 799-807 (1991)... 

Arico, B. Miller, J.E Roy, C. Stibitz, S. Monack, D. Falkow, S. Gross, R. Rappuoli, R. Sequences required for expression of Bordetella pertussis virulence factors share homology with prokaryotic signal transduction proteins. Proc. Natl. Acad. Sci. USA, 86, 6671-6675 (1989)... 

Aiba, H. Nagaya, M. Mizuno, T Sensor and regulator proteins from the cyanobacterium Synechococcus species PCC7942 that belong to the bacterial signal-transduction protein families implication in the adaptive response to phosphate hmitation. Mol. Microbiol., 8, 81-91 (1993)... 

Bastiaens PIH, Verveer PJ, Squire A, Wouters F (2001) Fluorescence lifetime imaging microscopy of signal transduction protein reactions in cells. In Valeur B, Brochon JC (eds) Springer series on fluorescence 1 (New trends in fluorescence spectroscopy). Springer, Berlin Heidelberg New York p 297-302... 

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