Molecular recognition properties

Apart from the successful imprinting discussed above, the recognition for many templates is far from that is required for the particular application, even after careful optimization of the other factors affecting the molecular recognition properties. Often, a large excess of MAA in the synthesis step is required for recognition to be observed and then only in solvents of low to medium polarity and hydrogen bond... 

Flower D.R. (1995). Multiple molecular recognition properties of the lipocalin protein family. J Mol Recog 8, 185-195. 

These are considered to be functionally competent protein domains owing to their ability to maintain their structure and molecular recognition properties independent of the full-length protein (Cohen GB, Ren R, Baltimore D. Modular binding domains in signal transduction proteins. Cell 1995 80 237-248). 

Etter, M. C., Z. Urbanczyk-Lipowska, M. Zia-Ebrahimi, and T. W. Pananto. 1990. Hydrogen Bond Directed Cocrystallization and Molecular Recognition Properties of Diaryl Ureas. J. Am Chem. Soc. 112, 8415. 

Many efforts to improve the efficiency and the selectivity of membrane processes are based on molecular recognition properties. 

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Stationary phases with specific molecular recognition properties for D,L-enantiomers of peptides have been tailored using the molecular imprinting technique. A template molecule is added to suitable monomer(s), the system is polymerized, and the chiral template molecule is washed out [128]. 

Biffis A, Graham NB, Siedlaczek G, Stalberg S, Wulff G. The synthesis, characterization and molecular recognition properties of imprinted microgels. Macromol Chem Phys 2001 202 163-171. 

Due to their specific molecular recognition properties, MIPs have found their main application in analytical chemistry. As outlined in the introduction, the common preparation method of MIPs as bulk polymers, which are subsequently crushed, ground and sieved to obtain particles, is not well adapted to achieve a high separation performance. Thus, the preparation of monolithic MIPs seemed particularly attractive for separation science due to the permeability properties, the easy in situ preparation and the absence of retaining frits. On the other hand, the use of the monolith format is still limited and the strategy of MIP monolith preparation has been little developed in recent years. 

Crossley et al. (95JCS(CC)1077) covalently linked two tetraarylporphyrins through the methanodiazocine bridge of TB to prepare well-defined chiral cleft-containing molecules 36 and 37a,b (Figure 8), whose molecular recognition properties could be... 

Molecular Recognition Properties of Nor-Seco-Cucurbit[10]uril... 

The use of DNA molecules as wires in electronic systems may open a new opportunity in nanoelectronics. DNA has the appropriate molecular recognition features and well-characterized self-assembly. There is evidence to suggest that DNA is only a marginally better electron conductor than proteins [116-118], As a result, many studies have focused on various methods of DNA modification leading to improvement in its conductive properties. It is possible to enhance the conductivity of DNA by coating it with a thin film of metal atoms, but the molecular recognition properties of the DNA are then destroyed. An effective approach to this problem is the incorporation of metal ions into the DNA double helix [118-121], Preliminary results suggest that a metal ion-DNA complex may be a much better conductor than B-DNA, because the former shows a metallic conduction whereas the latter behaves like a wide-band gap semiconductor [118]. 

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