Shiga toxin expression

Paton, A. W., Morana, R., and Paton, J. C. (2001). Neutralization of shiga toxins Stxl, Stx2, and Stx2e by recombinant bacteria expressing mimics of globotriose and globotetraose. Infect. Immun. 69,1967-1970. 

L. rhamnosus GG Inhibition of virulence factor expression Reduces expression of genes encoding shiga toxin Carey et al. (2008)... 

Carey, C. M., Kostryznska, M., Ojha, S., and Thompson, S. (2008). The effect of probiotics and organic acids on Shiga-toxin 2 gene expression in enterohemorrhagic Escherichia coli 0157 H7.. Microbiol. Methods [Epub.]. 

K. N. Guzman, C.A. Towards a vaccine candidate against shigella dysenteriae 1 expression of the shiga toxin B-sub-unit in an attenuated shigella flexneri AroD carrier strain. Microbial Pathogenesis 1996, 21, 277-288. 

As in other organs, ABCBl is the best investigated transporter in the liver. It was demonstrated that turpentine-induced APR leads to a 50-70% reduction of ABCBl expression and function in rat liver tissue 48 h after treatment [103]. Similar results were observed in studies of endotoxin-triggered inflammation in which both constitutive and induced expression were affected in rodents [104]. Further experiments have shown that reduction of ABCBl expression is also linked to a reduction in ABCBl function. In two distinct experimental setups, Shiga-toxin II and endotoxin administration to rats prompted a substantial reduction in ABCBl function (assessed by hepatobiliary doxorubicin and "TC-sestamibi clearance), accompanied by a significant reduction in ABCBl protein expression [69, 105]. Likewise, endotoxin-treated mice displayed decreased liver-mediated doxorubcin clearance as a result of... 

Ryd, M., Verma, N. and Lindberg, A.A. (1992) Induction of a humoral immune response to a Shiga toxin B subunit epitope expressed as a chimeric LamB protein in a Shigella flexneri live vaccine strain. Microb Pathog, 12, 399 07. 

Shiga toxin, which is produced by Shigella dysenteriae, and the homologous Shiga-like toxins (SLTs) ofE. coli, can cause serious clinical complications in humans infected by these organisms. The functional toxin receptor on mammalian cells is the glycolipid Gb3 [a-D-Gal(l 4) j3-D-Gal(l -> 4) 8-d-G1c(1 0-cer-amide)], and the high incidence of complications such as acute kidney failure in children correlates with the expression of Gb3 in the... 

Zhao, Y.L. et al. (2002) Shiga-like toxin II modifles brain distribution of a P-glycoprotein substrate, doxorubicin, and P-glycoprotein expression in mice. Brain Research, 956 (2), 246—253. 

---