Triiodothyronine serum

Burger A, Dinichert D, Nicod P, Jenny M, Lemarchand-Beraud T, Vallotton MB. Effect of amiodarone on serum triiodothyronine, reverse triiodothyronine, thyroxin, and thyrotropin. A drug influencing peripheral metabolism of thyroid hormones. J Clin Invest 1976 58(2) 255-9. 

Acute overdose of 13 g of propylthiouracil had no serious adverse effects, except for a temporary reduction in serum triiodothyronine (SEDA-5, 382). 

It has been suggested that thyroid status is a possible major regulator of metabolic rate. Herlihy et al. [38] found that CR reduces the 24-hour mean serum triiodothyronine (T3) level, but not the thyroxine (T4) level. CR appears to have this action because it attenuates the circadian amplitude in the concentrations of both hormones. However, Snyder et al. [39] found no effect of CR on either T4 or T3 in young rats and no consistent effect of CR on age-related changes in the concentrations of these two hormones. 

Sojka J E, Johnson M A, Bottoms G D 1993 Serum triiodothyronine, total thyroxine, and free thyroxine concentrations in horses. American Journal of Veterinary Research 54 52-55 Medical Economics Staff, PDR Staff and Physicians 2002 Physician s Desk Reference 2003, 57th edn. Thompson Healthcare, Montrale, NJ, pp. 569-571 Williams P D 1995 Equine Cushing s syndrome ... 

Phenytoin decreases the urinary excretion of 17-ketosteroids and 17-hydroxycorticosteroids by stimulating the conversion of cortisol to 6-P-hydroxycortisol it also diminishes serum FSH and the sperm count in semen, and thereby reduces fertility, Phenytoin also lowers the serum thyroxine concentration, probably by competitive displacement of thyroxine from its protein-binding sites free thyroxine also tends to be low. Serum triiodothyronine is low, probably as a result of stimulated metabohsm in the liver, but the concentration of TSH is unaffected by the altered thyroxine metabolism. 

Study (year) Serum triiodothyronine (pg/dl) Serum thyroxine (pg/dl) Serum TSH (uiU/mi)... 

A3. Abuid, J., Stinson, D. A., and Larsen, P. R., Serum triiodothyronine and thyroxine in the neonate and the acute increases in these hormones following delivery. J. Clin. Invest. 52, 1195-1199 (1973). 

B17. Brown, B. L., Ekins, R. P., ElUs, S. M., and Reith, W. S. A specific saturation assay technique for serum triiodothyronine. In In Vitro Procedures with Radioisotopes in Medicine, pp. 569-583. IAEA, Vienna, 1970. 

CIO. Chopra, I. J., Solomon, D. H., Chopra, U., Young, R. T., and Chua Teco, G. N., Alterations in circulating thyroid hormones and thyrotropin in hepatic cirrhosis Evidence for euthyroidism despite subnormal serum triiodothyronine. J. Clin. Endocrinol. Metab. 39, 501-511 (1974). 

F3. Fang, V. S., and Refetoff, S., Radioimmunoassay for serum triiodothyronine Evaluation of simple techniques to control interference from binding proteins. Clin. Chem. 20, 1150-1154 (1974). 

K6. Kirkegaard, C., Friis, T., and Siersbaek-Nielsen, K., Measurements of serum triiodothyronine by radioimmunoassay. Acta Endocrinol. (Copenhagen) 77, 71-81 (1974). 

M7. Mardell, R. J., A source of error in the automated serum triiodothyronine-uptake test. Clin. Chem. 16, 951-953 (1970). 

Wahner, H. W., Tj Hyperthyroidism. Mayo Clin. Proc. 47, 938-943 (1972). Wahner, H. W., and Gorman, C. A., Interpretation of serum triiodothyronine levels measured by the Sterling technic. N. Engl. J. Med. 284, 225-230 (1971). Watanalu, C.-L, Uematsu, M., and Horii, K.-L, Diphasic seasonal variation of the serum protein-bound iodine level. /. Clin. Endocrinol. Metab. 23, 383-386 (1963). 

Other Pharmacological Activity In mice orally administered 40 or 100 mg/kg neem leaf extract daily for 20 days, animals in the higher dose group had a decrease in serum triiodothyronine (T3) and increased serum thyroxine (T4) concentrations. No significant alterations of Tj or T4 levels were observed in the lower dose group (Panda and Kar 2000). 

Administration of "large doses" (dose not specified in English language abstract) of codonopsis in rats was reported to cause a reduction in weight gain and serum triiodothyronine (T3) levels, and an increase of reverse T3 and thyrotropin-releasing hormone (TRH) levels (Chen et al. 1989). 

An increase in serum triiodothyronine (Tj) and enhancement of the T3/T4 ratio were observed in mice orally administered a guggul extract at a dose of 0.2 g/kg daily for 15 days (Panda and Kar 1999). A ketosteroid isolated from guggul exhibited a strong thyroid-stimulatory action when administered to rats. Administration of 0.1 mg/kg caused an increase in iodine uptake by the thyroid and enhanced activities of thyroid peroxidase and protease (Tripathi et al. 1984). 

Administration of a dried hydroalcoholic extract of fenugreek seed in male mice and rats at doses of 110 mg/ kg for 15 days resulted in decreases in the serum triiodothyronine (T3) level and T3 T4 ratio but caused an increase in serum thyroxine (T4) level and body weight. The authors indicated that inhibition of T4 to T3 conversion was not peroxidation mediated and the inhibition in SOD activity could be the result of a decrease in the protein anabolic hormone, T3 (Panda et al. 1999). 

Dussault JH, Row VV, Lickrish G, Volp6 R, Studies of serum triiodothyronine concentration in maternal and cord blood Transfer of triiodothyronine across human placenta. J Clin Endocrinol 29 595 (1969)... 

Serum triiodothyronine (T3) was determined by RIA (separated by resin technique), with antibodies labelled by the Isotope Labelling Laboratory of the Atomic Energy Research Institute, Academia Sinica, Beijing. 

Iodine deficiency results predominantly in a reduction of serum thyroxine but serum triiodothyronine remains within the normal range. Only when iodine deficiency is extremely severe are the serum triiodothyronine levels compromised. 

Serum Triiodothyronine. Measurements in Human Serum by Radioimmunoassay with Corrobration by Gas-Liquid Chromatography J. Clin. Invest. 50(12) 2679-2688 (1971) CA 76 11770w... 

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