Metabolism selenium

Selenium metabolism and supplementation in patients with muscular dystrophy. Neurology 39, 655-659. 

Beilstein, M.A. and RD. Whanger. 1984. Effects of cyanide on selenium metabolism in rats. Jour. Nutr. 114 929-937. 

Selenium metabolism and degradation are significantly modified by interaction with heavy metals, agricultural chemicals, microorganisms, and a variety of physicochemical factors. 

Additional fundamental and basic research is required on selenium metabolism, physiology, recycling, interactions with other compounds or formulations, and chemical speciation in order to elucidate its nutritive role as well as its toxic effects. 

Heider, J. and Boeck, A. (1994) Selenium metabolism in microorganisms. Ado. Microbiol. Physiol, 35, 71-109. 

Patching, S.G. and Gardiner, RH.E. (1999) Recent developments in selenium metabolism and chemical speciation a review. /. Trace Elem. Electrolytes Health Dis., accepted for publication. 

LIG. 3 Routes of selenium metabolism in animals adapted from Jacques (2001), after Schrauzer (2000) Low and Berry (1996), and Daniels (1996). 

Beilstein, M.A. and Whanger, P.D. 1992. Selenium metabolism and glutathionine peroxidase activity in cultured human lymphoblasts. Biol. Trace Elem. Res. 35, 105-118. 

Jacques, K.A. 2001. Selenium metabolism in animals the relationship between dietary selenium form and physiological response. In Science and Technology in the Feed Industry (T.P. Lyons and... 

Olson, O.E. and Palmer, I.S. 1976. Selenoamino acids in tissues of rats administered inorganic selenium. Metabolism 25, 299. 

J. J. Wrench, Selenium metabolism in marine phytoplankters Tetraselmis tetrathele and Dunaliiella minuta, Mar. Biol., 49 (1978), 231-236. 

H. E. Ganther, Selenium metabolism, selenoproteins and mechanisms of cancer prevention complexities with thioredoxin reductase, Carcinogenesis, 20 (1999), 1657D1666. 

Coker, O.E. (1978) An investigation into selenium metabolism with reference to the interactions between vitamin E, selenium and other trace elements. Ph. D. Thesis, University of London. 

The exclusion of selenium from the proteins of accumulator plants is thought to be the basis for their selenium tolerance. Their selenium metabolism is based mainly on water-soluble nonprotein forms such as selenium methylselenomethionine (Jacobs, 1989). The garlic odor characteristic of selenium-accumulator plants reflects the volatile organic compounds dimethylselenide and dime-thyldiselenide. Plants can suffer selenium toxicity as a result of selenium competition with essential metabolites for biochemical sites, replacement of essential ions by selenium, mainly major cations, selenate occupation of the sites of essential groups such as phosphate and nitrate, or selenium substimtion in essential sulfur compounds. 

Ongoing investigations into selenium metabolism include state-of-the-art methods such as HPLC/ICPMS in combination with MS/MS. Data on the profile of selenium metabolites will elucidate the element s essential and toxic roles and relate individual Se species with observed health effects. 

Figure 12.4 The proposed selenium metabolism (GS- glutathione conjugate). From Gammelgaard,...

Ganther, H Roswell Park Memorial Institute Selenium metabolism and anti-carcinogenic action CRISP 2001... 

Ip, C Roswell Park Memorial Institute Mammary cancer prevention by novel selenium compounds selenium metabolism and cancer prevention CRISP 2001... 

Whanger, P Oregon State University Role of selenium and vitamin E in scour and immunity of newborn calves influence of pregnancy on selenium metabolism in women of low selenium status metabolic relationship between selenium and myopathy CRIS/UDSA 2001... 

Alfthan G, Aro A, Arviloimni H, et al. 1991. Selenium metabolism and platelet glutathione peroxidase activity in healthy Finnish men Effects of selenium yeast, selenite, and selenate. Am J Clin Nutr 53(1) 120-125. 

Cohen HJ, Avissar N. 1993. Molecular and biochemical aspects of selenium metabolism and deficiency. Prog Clin Biol Res 380 191-202. 

Daniels LA. 1996. Selenium metabolism and bioavailability. Biol Trace Elem Res 54 185-199. 

Ganther HE, Baumann CA. 1962. Selenium metabolism. I. Effects of diet, arsenic and cadmium. J Nutr 77 210-216. 

Garberg P, Thullberg M. 1996. Decreased glutathione peroxidase activity in mice in response to nafenopin is caused by changes in selenium metabolism. Chem Biol Interact 99 165-177. 

Heinrich MJ, Kelsey FE. 1955. Studies on selenium metabolism The distribution of selenium in the tissues of the mouse. J Pharmacol Exp Ther 114 28-32. 

Hirooka T, Galambos JT. 1966a. Selenium metabolism. III. Serum proteins, lipoproteins and liver injury. Biochim Biophys Acta 130 321-328. 

Janghorbani M, Christensen MJ, Nahapetian A, et al. 1982. Selenium metabolism in health adults Quantitative aspects using the stable isotope 74Se03(2-). Am J Clin Nutr 35 647-654. 

Krishnamurti CR, Ramberg CF, Jr, Shariff MA. 1989. Kinetic modeling of selenium metabolism in nonpregnant ewes. J Nutr 119(8) 1146-1155. 

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