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SELDI mass spectrometry

As noted earlier in the chapter, ICP-MS is used for the determination of trace elements in many types of samples (see Chapter 35). However, it is known that the toxicity of an element may depend on the organic or inorganic state in which the element is present. In these cases it is more important to ascertain the concentrations of toxic species rather [Pg.184]


Wright, G. L., Cazares, L. H., Leung, S.-M., Nasim, S., Adam, B.-L., Yip, T.-T., Schellhammer, P. F., Gong, L., and Vlahou, A. (2000). ProteinChip surface enhanced laser desorption/ionization (SELDI) mass spectrometry a novel protein biochip technology for detection of prostate cancer biomarkers in complex protein mixtures. Prostate Cancer and Prostatic Diseases 2, 264-276. [Pg.124]

Ball, G., Mian, S., Holding, R, Allibone, R.O., Lowe, J., Ali, S., Li, G., McCardle, S., Ellis, I.O., Creaser, C., and Rees, R.C., An integrated approach utilizing neural networks and SELDI mass spectrometry for classification of human tumours and rapid identification of potential biomarkers. Bioinformatics, 18, 395 04, 2002. [Pg.234]

Zhukov TA, Johanson RA, Cantor AB, Clark RA, Tockman MS. Discovery of distinct protein profiles specific for lung tumors and pre-malignant lung lesions by SELDI mass spectrometry. Lung Cancer 2003 40(3) 267-279. [Pg.136]

Melle C, Osterloh D, Ernst G, Schimmel B, Bleul A, von Eggeling F. Identification of proteins from colorectal cancer tissue by two-dimensional gel electrophoresis and SELDI mass spectrometry. Int J Mol Med 2005 16(1) 1117. [Pg.137]

Protein Chip technology, it will be possible to simultaneously analyze protein profiles of body fluids such as serum and urine samples very rapidly. The SELDI mass spectrometry in conjunction with bioinformatics tools could greatly facilitate the discovery of new and improved toxicologic biomarkers. [Pg.871]

Wright, G.L. Cazares, L.H. Leung, S.M. et al. ProteinChip Surface Enhanced Laser Desorption/ionization (SELDI) Mass Spectrometry A Novel Protein Biochip Technology for Detection of Prostate Cancer Biomarkers in Complex Protein Mixtures, Prostate Cancer and Prostatic Dis., 2, 264-276 (2000). [Pg.119]

Forde, C.E. Gonzales, A.D. Smessaert, J.M. Murphy, G.A. Shields, S.J. Fitch, J.P McCutchen-Maloney, S.L. A Rapid Method to Capture and Screen for Transcription Factors by SELDI Mass Spectrometry, Biochem. Biophys. Res. Commun. 290, 1328-1335 (2002). [Pg.119]

Diamond DL, Zhang Y, Gaiger A, et al. Use of ProteinChip array surface enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) to identify thymosin beta-4, a differentially secreted protein from lymphoblastoid cell lines. J. Am. Soc. Mass Spectrom. 2003 14 760-765. [Pg.330]

Fetsch PA, Simone NL, Bryant-Greenwood PK, et al. Proteomic evaluation of archival cytologic material using SELDI affinity mass spectrometry potential for diagnostic applications. Am. J. Clin. Pathol. 2002 118 870-876. [Pg.331]

Proteomics has the potential to revolutionize diagnosis and disease management. Profiling serum protein patterns by means of surface-enhanced laser desorption/ion-isation time of flight (SELDI-TOFF) mass spectrometry is a novel approach to... [Pg.133]

Thulasiraman Y, Wang Z, Katrekar A, Lomas L, Yip TT. Simultaneous monitoring of multiple kinase activities by SELDI-TOF mass spectrometry. Methods Mol Biol 2004 278 205-214. [Pg.437]

The Bik glycoprotein has an isoelectric point (p/) of 2.1 and is composed of a peptide and two glycoconjugate portions [30]. The predicted peptide sequence of Bik is helpful to understanding protein function. The peptide has Kunitz-binding domains I and II attached to the N-terminal peptide tail [31-33] (Fig. 2). Protein mass spectrometry by surface-enhanced laser desorption ionization (SELDI) in combination with detection by Bik antibodies has demonstrated that substantial variation exists in the Bik molecule [13,14]. [Pg.228]

RC-MS stems from the observation that mass spectra of peptides and proteins can be generated by laser activation of chromatographic surfaces placed on MALDI targets. The product application of RC-MS, called surface-enhanced laser desorption ionization-time of fiight (SELDI-TOF), refers to a mass spectrometry method for measuring native proteins adsorbed (retained) on various chemical or biochemical surfaces (Figure 4.11). Although the concept of laser desorption of intact proteins is well established, it has been commercially exploited only recently as a means... [Pg.59]

Engwegen, J. Y., Gast, M. C., Schellens, J. H., and Beijnen, J. H. Clinical proteomics searching for better tumour markers with SELDI-TOF mass spectrometry. Trends Pharmacol. Sci. 27, 251-259, 2006. [Pg.66]

Label-free optical techniqnes for detecting bound proteins on microarrays have been recently reviewed. The advantage of these methods over labeling methods is that the native form of the analyte is preserved. These methods include SPR, surface-enhanced laser desorption/ionization mass spectrometry (SELDI-MS), atomic force microscopy " and fiber-optic methods. [Pg.298]

Surface-enhanced laser/desorption ionization mass spectrometry Protein-Chip . See Tang, N., Tomatore, P, and Weinberger, S.R., Current developments in SELDI affinity technology. Mass Spectrom. Rev. 23a, 34-44,2004. [Pg.207]

SELDI-TOF Fractionation based on selective binding to activated surfaces followed by MS determination of m.w., automatic fast sample processing combined widi mass spectrometry. Analytical... [Pg.727]


See other pages where SELDI mass spectrometry is mentioned: [Pg.184]    [Pg.109]    [Pg.184]    [Pg.109]    [Pg.96]    [Pg.328]    [Pg.366]    [Pg.367]    [Pg.13]    [Pg.337]    [Pg.120]    [Pg.404]    [Pg.73]    [Pg.71]    [Pg.104]    [Pg.221]    [Pg.43]    [Pg.60]    [Pg.60]    [Pg.227]    [Pg.259]    [Pg.270]    [Pg.3048]    [Pg.110]    [Pg.114]    [Pg.122]    [Pg.130]    [Pg.281]   
See also in sourсe #XX -- [ Pg.184 ]




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