N-terminal peptides

Species Strain Gene/ Protein No. of amino acids including N-terminal leader peptide/N-terminal leader peptide Lattice type GenBank accession no. 

Coincidentally, by aiming the peptide N-terminal amino group in our 3-D ligand-receptor complex toward Glu-347, rather than Asp-256,32 we identified a hydrophobic pocket as a possible component for interaction with Phe-43 in the agonist peptide motif. This hydrophobic cluster involves residues Phe-182, Leu-340, Tyr-337, and Phe-339 (Figure 9). Assignment of the stop and start residues for... 

Momordica cochinchinensis (Vietnamese squash) (Cucurbitaceae) [seed] MCoTl-III (30 aa 3.4 kDa 6 Cys linear peptide N-terminal pyroglutamyl) Trypsin (R6-I7) [541]... 

Lewis, A., Wilkie, J., Rutherford, T.J. and Gani, D. (1998) Design, construction and properties of peptide N-terminal cap templates devised to initiate a-helices. Part 2. Caps derived from N-[(2S)-2-chloropropionyl]-(2S)-Pro-(2S)-Pro-(2S,4S)-4-thioPro-OMe. /. Chem. Soc. Perkin Trans. 1 3777 -3793. 

Fig. 5. The structures of unusual SH2 domain-containing proteins. (A) Stereo diagram of the N-terminal region of SAP in complex with a tyrosine phosphorylated peptide from SLAM. Color-coding of secondary structures and residues is as in Fig. 2. Note that the SAP SH2 domain makes extensive contacts with the residues of the peptide N-terminal region to the pTyr, an unusual feature for SH2 domains. (B) Stereo diagram...

Remarkable advances in the field of peptide organocatalysis have been made in recent years. Asymmetric synthesis employing IV-allqrl imidazole-based peptides, N-terminal prolyl peptides, N-terminal primary amino peptides, supported N-terminal prolyl peptides as well as oligopeptides have become a facile tool in organic chemistry. 

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