Seaweed sulfated polysaccharides

Carrageenan. The term carrageenan [19000-07-1] is the generic description for a complex mixture of sulfated polysaccharides that are extracted from certain genera and species of the class Fhodophjceae red seaweed. 

Seaweed Various sulfated polysaccharides extracted from seaweed (i.e., Nothogenia fastigiata, Aghardhiella tenera) inhibit the virus adsorption process. 

Abstract The inhibitory action of polyanionic substances on virus replication was reported more than 50 years ago. Seaweeds, marine invertebrates, and higher plants represent abundant sources of novel compounds of proved antiviral activity. Natural sulfated polysaccharides (SPs) are potent in vitro inhibitors of a wide variety of enveloped viruses, such as herpes simplex virus (HSV) types 1 and 2, human immunodeficiency virus (HIV), human cytomegalovirus (HCMV), dengue virus (DENV), respiratory syncytial virus (RSV), and influenza A virus. Several polysulfate compounds have the potential to inhibit virus replication by blocking the virion binding to the host cell. In contrast, their in vivo efficacy in animal and human systemic infections has undesirable draw-... 

Keywords Antiviral activity Chemical structure Natural sulfated polysaccharides Polyanions Seaweeds... 

M. C. Matulewicz and A. S. Cerezo, Water-soluble sulfated polysaccharides from the red seaweed Chaetangiumfastigiatum. Analysis of the system and the structures of the a-D-( 1 —>3)-linked mannans, Carbohydr. Polym., 7 (1987) 121-132. 

Carrageenan Thermoreversible gelling agent Sulfated polysaccharide Red seaweeds... 

Carrageenan, a sulfated polysaccharide extracted from red seaweed, may be separated into a number of... 

Logeart D, Prigent-Richard S, Boisson-Vidal C, et al. (1997). Fucans, sulfated polysaccharides extracted from brown seaweeds, inhibit vascular smooth muscle cell por-liferation. IF Degradation and molecular weight effect. Euro. J. Cell Bio. 74 385-390. 

Marine algae are potentially prolific sources of highly bioactive components that might represent useful leads in the development of new pharmaceutical agents and functional foods. This chapter discusses the current literature on biological activities of sulfated polysaccharides, fucoidans, from brown seaweeds. The profound functional properties of fucoidans could be employed in pharmaceutical, nutraceutical functional food, and cosmeceutical... 

Fucose-containing sulfated polysaccharides from brown seaweeds might exhibit interesting biological properties (Matsuhiro et ah, 1996). The profound functional properties of the sulfated polysaccharides are probably due to the presence of sulfate groups in varying amounts. In addition. 

TABLE 12.1 Biological activities of fucose-rich sulfated polysaccharides and fucoidan isolated from various brown seaweeds... 

Over the years, isolation and purification of natural sulfated polysaccharides responsible for anticoagulant activity from different seaweed species had been reported (De Zoisa et ah, 2008). The ability of sulfated polysaccharides to interfere with biological systems has a longstanding record, as illustrated with heparin (Huynh et ah, 2001). In addition, anticoagulant and antithrombotic activities are among the most widely studied properties of sulfated polysaccharides. 

Athukorala et ah (2006) tested anticoagulant activity of fucose-contain-ing sulfated polysaccharide isolated from brown seaweed . cava... 

De Zoisa et al. (2008) reported the isolation and characterization of fucose-containing sulfated polysaccharide as an anticoagulant agent from the edible brown seaweed Sargassum fulvellum by means of a simple fermentation process and chromatography technique. According to their... 

In recent years, it has been reported that fucose-rich sulfated polysaccharides isolated from brown seaweeds exhibited antitumor activity which is one of the most important biological activities of seaweeds. 

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