Scanning, mass spectrometry

Figure 13.7. The image of a fingerprint taken from a glass sheet surface (10,000 x 10,000 j,m). (Reprinted from Szynkowska, M. I. et al., 2007. Preliminary Studies Using Scanning Mass Spectrometry (TOF-SIMS) in the Visualisation and Analysis of Fingerprints, Imaging Sci. J., 55 180-187. With permission from Maney Publishing.) (See color insert.)...

Data-dependent software programs allow real-time decisions to be made during an analysis. This approach features a preestablished threshold for the detection of a peak during full-scan mass spectrometry and MS/MS scan modes. If a peak of interest is detected in real-time, then the mass spectrometer is switched from full-scan mode to another scan mode to obtain more information from the same analysis. For example, the system may be automatically switched to the production mode during the analysis of a chromatographic peak to obtain substructural information. Thus, more detailed information is obtained in fewer analyses. This powerful... 

The development and use of various protein sequence databases for automated search routines (Eng et al., 1994 Clauser et al., 1999) are an essential component of protein analysis that uses mass spectrometry techniques. These programs (i.e., SEQUEST, MASCOT) require only a few peptides for matching therefore, the absence of a match for a particular peptide does not affect the search performance. Using protein database searches provides an efficient way of confirming a putative sequence from corresponding full-scan mass spectrometry and MS/MS data. 

For abbreviation of analyte names see Sect. Abbreviations . ACN acetonitrile, APCI atmospheric pressure chemical ionization, dial, microdialysis samples, ESI electrospray ionization, FA formic acid, iso isocratic, IT ion trap, lin range linear range, MeOH methanol, MRM multiple reaction monitoring, MS full scan mass spectrometry, n.s. not specified, OAc acetate, QqQ triple quadrupole mass spectrometer, SIM selected ion monitoring, Solv HPLC solvent, SQ single quadrupole mass spectrometer, T temperature Ratios given as v/v... 

Mullen, W. Larcombe, S. Arnold, K. Welchman, H. Crozier, A. 2010. Use of accurate mass full scan mass spectrometry for the analysis of anthocyanins in berries and berry-fed tissues. J. Agric. Food Chem. 58 3910-3915. 

Fully-automated systematic toxicologic analysis of drugs, poisons, and metabolites in whole blood, urine and plasma by gas chromatography-fuh scan mass spectrometry. J Chromatogr 1998 713 265-79. 

Li, N., Assmann,)., Schuhmann, W., and Muhler, M. (2007) Spatially resolved characterization of catalyst-coated membranes by distance-controlled scanning mass spectrometry utilizing catalytic methanol oxidation as gas-solid probe reaction. Analytical Chemistry, 79 (15), 5674-5681. 

Montaudo, G., Puglisi, C., Scamporrino, E., and Vitalini, D. Identification of Pyrolysis Products of Polysulfides by CAD-Linked Scanning Mass Spectrometry, /. Anal Appl Pyrolysis, 10, 283,1987. 

The GC/MS applications discussed above demonstrate clearly that ion traps provide excellent data for applications, despite a history of poor performance in early ion trap designs. Qualitative and quantitative analysis in heavy matrices are possible because increased ion trapping capacity and ion population control is available in modern instrumentation. The technology has been accepted for use with major USEPA methods as a routine analytical tool for challenging environmental samples. The analyzer is versatile, because scan modes such as MS/MS, liquid Cl, hybrid Cl, and full scan mass spectrometry can be performed on the same instrument. This instrumental versatility reduces cost and increases specificity by providing more information about the molecules under study. 

Why is it important to use a rapid-scanning mass spectrometry system for data collection from a high-resolution separation device ... 

Y.-S. Chang and J. T. Watson, Charge-remote fragmentation during FAB-CAD-B/E linked-scan mass spectrometry of (aminoethyl)triphenylphosphonium derivatives of fatty acids, J. Am. Soc. Mass Spectrom. 3, 769-775 (1992). 

EBR-II (USA) thermal conductivity, flame emission, Ge-Li gamma scan mass spectrometry... 

Van Thuyne W, Van Eenoo P, Delbeke FT (2008) bnplcanentation of gas chnunatography combined with simultaneously selected ion morritraing and full scan mass spectrometry in doping analysis. J Chromatogr A 1210 193—202... 

Desiderio DM, Sabbatini JZ. Field desorption collision activation linked scanning mass spectrometry of underivatized oligopeptides. Biol Mass Spectrom. 2005 8 565. 

Herrera Rivera Z, Oosterink E, Rietveld L, Schoutsen F, Stolker L. Influence of natural organic matter on the screening of pharmaceuticals in water by using liquid chromatography with full scan mass spectrometry. Anal Chim Acta 2011 700(1—2) 114—25. 

Methods have been reported to differentiate between isomeric 2, 3 -, and 5 -deoxynucleosldes using E.I. and C.l.-linked scanning mass spectrometry. 84... 

FIG. 4. TIC curve of urine extract in a case of multiple overdosage studied by repetitive scanning mass spectrometry. Drugs, metabolites and "artifacts identified are ... 

Desiderio, D. M., and I. Katakuse Fast Atom Bombardment-Collision Activated Dissociation-Linked Field Scanning Mass Spectrometry of the Neuropeptide Substance P. Analyt. Biochem. 129, 425 (1983). 

In Chapter 17, the combination of SECM with other techniqnes has been presented. Hybrid systems, like SECM-AFM, are useful for obtaining more information abont processes at an interface. In addition to these techniques, SECM can be combined with other methodologies that allow further sample analysis and afford the extraction of sample structural information, for instance, by coupling SECM with mass spectrometry (MS). Several approaches for scanning mass spectrometry have been reported for the spatial detection of different species at solid-liqnid, liquid-liquid, or air-solid interface. Both chemical " and electrochemical reactions have been characterized by these means. These approaches are based on the use of concentric capillaries that allow the flux of carrier gas or redox components to the substrate (i.e., through the outer capillary) and the extraction... 

Kottke, P. A., Degertekin, R L., Fedorov, A. G. Scanning mass spectrometry probe A scanning probe electrospray ion source for imaging mass spectrometry of submerged interfaces and transient events in... 

Li, N., Eckhard, K., Assmann, J., Hagen, V., Otto, H., Chen, X., Schuhmann, W., Muhler, M. Scanning mass spectrometry with integrated constant distance positioning. Review of Scientific Instruments 2006, 77, 084102. 

Bjom, E., Baxter, D. C., and Freeh, W. (2002) Calibration errors due to variation in peak characteristics in the measurement of transient signals by inductively coupled plasma-scanning mass spectrometry. J. Anal. At. Spectrom., 17,1582-8. 

Balsanek, W. J., Venable, J. D., and Holcombe, J. A. (2003) Generation of a square wave inductively coupled plasma scanning mass spectrometry signal using electrothermal vaporization sample introduction. J. Anal At. Spectrom., 18,59-64. 

---