High-resolution scans mass spectrometry

Mol, H. G. J., Zomer, R, and de Koning, M. 2012. Quahtative aspects and validation of a screening method for pesticides in vegetables and fruits based on hquid chromatography coupled to full scan high resolution (Orbitrap) mass spectrometry. Anal. Bioanal. Chem. 403 2891-2908. 

Fung,E.N.,Xia,Y.Q.,Aubry,A.F.,Zeng,I,Qlah,T.,Jemal, M. (2011) Full-scan high resolution accurate mass spectrometry (HRMS) in regulated bioanalysis LC-HRMS for the quantitation of prednisone and prednisolone in human plasma./owma/ of Chromatography B Analytical Technologies in the Biomedical and Life Sciences,879 Tl), 2919-2927. 

Mol HGJ, Van Dam RCJ, Zomer P, MuIOct PPJ (2011) Soeening of plant toxins in food, feed and botanicals using full-scan high-resolution (Orbitrap) mass spectrometry. Food Addit Contam 28(10) 1405-1423... 

Gavrilov, K.L., Bennison, S.J., Mikeska, K.R., Chabala, J.M. and Levi-Setti, R., Silica and magnesia dopant distributions in alumina by high-resolution scanning secondary ion mass spectrometry ,, /. Am. Ceram. Soc., 1999 82(4) 1001-1008. 

Bouschen W, Spengler B (2007) Artifacts of MALDI sample preparation investigated by high-resolution scanning microprobe matrix-assisted laser desorption/ionization (SMALDI) imagine mass spectrometry. Int 1 Mass Spectrom 266 129-137. doi 10.1016/j. ijms.2007.07.017... 

The three-dimensional quadupole field ion trap - or Paul trap is a three-electrode device [see Figure 4.5(b)]. Ions are injected into the device and collected in packets from an ESI or MALDI source. The ion trap analyzer is capable of MS, MS" (MS = MS-MS-MS) and high-resolution scans (R = 20,000). The ion packets enter through an entrance-end cap and are analyzed by scanning the RF amplitude of the ring electrode. The ions are resonated sequentially from low to high m/z and are ejected from the ion trap through the exit-end cap electrode to a detector. Unlike the triple quadrupole (QqQ) mass spectrometer discussed previously, the ion trap performs tandem mass spectrometry (MS-MS) scan modes in the same analyzer. 

Why is it important to use a rapid-scanning mass spectrometry system for data collection from a high-resolution separation device ... 

Bouschen, W., Schulz, O., Eikel, D., and Spengler, B. (2010) Matrix vapor deposition/recrystallization and dedicated spray preparation for high-resolution scanning microprobe matrix-assisted laser desorption/ionization imaging mass spectrometry (SMALDl-MS) of tissue and single cells. Rapid Commun. Mass Spectrom., 24, 355-354. 

Polymer/additive analysis greatly benefits from high-resolution mass data, which often leads to unambiguous identification of (known) additives. However, the investment and operating costs of this instrument do not easily justify its (exclusive) use for the purpose of routine polymer/additive analysis. Analysis of organic polymer additives by means of mass spectrometry is aided by the utilisation of precursor ion and second-generation product ion (MS3) scanning experiments [169], A four-sector... 

TOF analyzers are especially compatible with MALDI ion sources and hence are frequently coupled in aMALDI-TOF configuration. Nevertheless, many commercial mass spectrometers combine ESI with TOF with great success. For proteomics applications, the quadrupole TOF (QqTOF) hybrid instruments with their superior mass accuracy, mass range, and mass resolution are of much greater utility than simple TOF instruments.21,22 Moreover, TOF instruments feature high sensitivity because they can generate full scan data without the necessity for scanning that causes ion loss and decreased sensitivity. Linear mode TOF instruments cannot perform tandem mass spectrometry. This problem is addressed by hybrid instruments that incorporate analyzers with mass selective capability (e.g., QqTOF) in front of a TOF instrument. 

The oxygen transfer from an ortho nitro group to a carbon-carbon triple bond has been studied by high-resolution mass spectrometry, linked scan techniques and chemical substitution81. Oxygen transfers to both acetylenic carbons were detected as parallel fragmentation pathways81. 

In general, the quadrupole instruments do not achieve the mass range and the high resolution of sector instruments. However, the mass range and resolution are adequate for unit-resolution mass spectrometry, and the rapid scan and sensitivity make them especially suitable for use with capillary gas chromatography (Fig. 2.46). 

The determination of TCDD in the final extract was by high resolution mass spectrometry multiple scan averaging. No gas chromatography was employed the sample was vaporized via the direct insertion probe (12.13). This method is inherently more prone to interferences than GC-MS (17.18) the response observed may not be due to TCDD. The results do serve as an indication, however, that if TCDD is present in human milk it is at 1 ppt or less. Thus any methods developed must be capable of this detection limit. 

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