Single quadrupole mass spectrometers

The ions formed are extracted by the extraction lens, EL, perpendicular to the electron beam. Due to the low energy spread of ions formed in an electron ionization source (< 1 eV) one single-focusing magnetic sector field mass spectrometer or quadrupole analyzer is sufficient for... 

Aside from the single mass filter, the most common configuration for quadrupole mass spectrometers is the triple-quadrupole instrument. This is the simplest tandem mass spectrometer using quadrupole mass filters. Typically, the... 

G. J. Opiteck, J. W. Jorgenson, M. A. Moseley III and R. J. Anderegg, Two-dimensional mia ocolumn HPLC coupled to a single-quadrupole mass spectrometer for the elucidation of sequence tags and peptide mapping , 7. Microcolumn Sep. 10 365-375 (1998). 

In general, the mass resolution required for most analyses is such that the singly charged isotope patterns of the detected ions are readily discernible. For applications involving molecular weights up to about 1500 Da, this can be provided by magnetic sector, quadrupole, and time-of-flight mass spectrometers. 

Currently PCR and mass spectrometry are performed by two separate instruments. However, there is no reason why PCR followed by simple automated cleanup and mass spectrometry cannot be incorporated into a single integrated instrument. Essentially every configuration of the modern ESI mass spectrometer has been used successfully for the analysis of PCR products, from the highest to the lowest resolution involving. Fourier transform ion cyclotron resonance (FTICR), triple quadrupole, quadrupole-time of flight (Q-TOF), and ion trap.22-24 MS discriminates between two structurally related PCR products by MW difference. Mass accuracy is needed to differentiate the... 

Voyskner, R. D. Pack, T. Investigation of collisional-activation decomposition process and spectra in the transport oregion of an electrospray single-quadrupole mass-spectrometer. Rapid Comm. Mass Spectrom. 1991, 5, 263-268. 

Like sector analyzers, quadrupole analyzers are well suited for continuous ion sources such as ESI, but are not well-suited for pulsed ionization methods. Quadmpole mass spectrometers are generally substantially cheaper and smaller than sector instruments and Qq-TOFs. They are very often used in combination with GC and LC, and single or triple quadmpole mass filters are very common benchtop instruments for routine measurements. 

SSQ 70 series single-stage quadrupole-mass spectrometer... 

In addition to the diversity of ionisation techniques available, mass spectrometers offer a selection of mass analyser configurations. Of note are single (MS) and triple quadrupole (MS—MS) instruments, ion trap analysers (MS)n, time-of-flight (ToF) analysers, sector field analysers, and Fourier transform-ion cyclotron resonance (FTICR) instruments. 

Detection modes of single and triple quadrupole mass spectrometers... 

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