Scaffold polymerization

Guo R, et al. A transient cell-shielding method for viable MSC delivery within hydrophobic scaffolds polymerized in situ. Biomaterials 2015 54 21-33. 

SARA is a scaffolding protein that regulates the subcellular localization of inactivated R-Smads, potentially scaffolding the TGF-P receptor kinase to the Smad 2 substrate. Filamins are a family of actin polymerization proteins that also form scaffolds for a range of signaling proteins including SAP kinases such as MKK-4, small GTPases Rho and Ras, as well as Smad 2 and Smad 5. 

Multiple applications for resilin-like polypeptides have garnered renewed research interest since the report of the first recombinant resilin in 2005. The excellent mechanical properties of the resilin-like polypeptides has directed investigation toward their use as high-performance materials and in tissue engineering applications. It is widely acknowledged that cells interact and take cues from their microenvironment and, therefore, the development of polymeric scaffolds to mimic the extracellular matrix and drive desired cell or tissue responses has been of wide interest. To this end, our laboratories have developed a modular resilin-like polypeptide (RLP12) (see Fig. 20) that contains not only twelve repeats of the... 

Advances in Tissue Engineering Approaches to Treatment of Intervertebral Disc Degeneration Cells and Polymeric Scaffolds for Nucleus Pulposus Regeneration... 

The polymerization of several different protected monomers was executed with the molybdenum initiator. Two types of norbornene templates were generated as mixtures of diastereomers one class possessed a single saccharide substituent attached through either an endo or exo ester group, and the other was equipped with two carbohydrate residues appended to the bicyclic scaffold... 

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