Strategies Toward Noncovalent Side Chain Functionalization of Polymeric Scaffolds

STRATEGIES TOWARD NONCOVALENT SIDE CHAIN FUNCTIONALIZATION OF POLYMERIC SCAFFOLDS 

Side chain functionalization of covalently functionalized pol5mers can take place either by prepolymerization functionalization, which is the functionality that has been bestowed to the monomer, or by postpolymerization functionalization, which is after the polymerization, when the polymer backbone is subsequently functionalized with the desired moiety (Pollino and Week 2005). Although both approaches have been employed successfully in covalent pol5mer chemistry, the first approach can be synthetically more demanding but always yields 100% functionalization, which is not the case for most postpolymerization functionalization strategies. 

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