G protein signaling

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Neubig, R. R., and Siderovski, D. P. (2002). Regulators of G-protein signaling as new central nervous system drug targets. Nature Rev. Drug Disc. 1 187—196. 

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Bansal G, Xie Z, Rao S, Nocka KH, Druey KM Sup- 54 pression of immunoglobulin E-mediated allergic responses by regulator of G protein signaling 13. 

Papayannopoulou T, Priestley GV, Bonig H, Nakamoto B. The role of G-protein signaling in hematopoietic stem/progenitor cell mobilization. Blood 2003 101(12) 4739-4747. 

Alkhatib G, Locati M, Kennedy PE, Murphy PM, Berger EA. HIV-1 coreceptor activity of CCR5 and its inhibition by chemokines independence from G protein signaling and importance of coreceptor downmodulation. Virology 1997 234(2) 340-348. 

Mimics, K., Middleton, F. A., Stanwood, G. D., Lewis, D. A. and Levitt, P. (2001), Disease-specific changes in regulator of G-protein signaling 4 (RGS4) expression in schizophrenia , Mol. Psychiat.,... 

The SH2 DOMAIN links an activated (autophosphorylated) receptor to various downstream pathways. Each of the proteins has a common SH2 adaptor domain fused to another domain that performs the downstream function. The same signal can then activate multiple pathways. GNRP and GAP represent adaptors that can affect G-protein signaling (see the following section G-Protein Coupled Receptors ). 

Recent research has implicated GPy subunits in mediating G-protein signaling in the absence of activation of... 

An increasing number of G proteins and RGS proteins have been deleted or overexpressed in genetic mutant mice. Not surprisingly, some of these mice exhibit complex behavioral abnormalities and in some cases abnormal responses to psychotropic drugs. These data further highlight the importance of G protein signaling in the brain in health and disease and open new paths for investigation in the years ahead. 

Ross, E. M. and Wilkie, T. M. GTPase-activating proteins for heterotrimeric G proteins regulators of G protein signaling (RGS) and RGS-like proteins. Annu. Rev. Biochem. 69 795-827, 2000. 

Gold,S. J.,Ni,Y. G.,Dohlman,H. andNestler,E. J. Regulators of G protein signaling Region-specific expression of nine subtypes in rat brain. /. Neurosci. 7 8024-8037,1997. 

Blumer, J. B. and Lanier, S. M. Accessory proteins for G protein-signaling systems activators of G protein signaling and other nonreceptor proteins influencing the activation state of G proteins. Receptors Channels 9 195-204, 2003. 

Ross, E. M. Palmitoylation in G protein signaling pathways. Curr. Biol. 5 107-109,1995. 

PEPCK phosphoenolpyruvate carboxykinase RGS regulators of G protein signaling... 

Normalizes or inhibits secondary messenger systems (e.g, inhibits phos-phoinositide and adenylate cyclase signaling normalizes guanine nucleotidebinding protein [G protein] signal transduction system) ... 

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