Salicylate hypersensitivity

There are few contraindications to combination salicylic acid/TCA peeling. The combination regimen is tolerated in all skin types and all ra-cial/ethnic groups. General contraindications include salicylate hypersensitivity unrealistic patient expectations active inflammation/der-... 

Hypersensitivity to sulfonamides or chemically related drugs (eg, sulfonylureas, thiazide and loop diuretics, carbonic anhydrase inhibitors, sunscreens with PABA, local anesthetics) pregnancy at term lactation infants less than 2 months of age (except in congenital toxoplasmosis as adjunct with pyrimethamine) porphyria salicylate hypersensitivity. 

Ulcerative colitis Action 5-ASA derivative, anti-inflammatory, 1 leukotiiene synth Dose 2.25 g (3 caps) tid x 8-12 wk Caution [B, ] Severe renal/hepatic failure Contra Mesalamine or salicylates hypersensitivity Disp Caps SE Dizziness, HA, N, agranulocytosis, pancytopenia, renal impair, allergic Rxns Interactions Oral antibiotics may interfere W/ mesalamine release in the colon EMS Allergic Rxn can occur if pt is allergic to ASA or other salicylates OD Not reported but may cause V, tinnitus, confusion and vertigo symptomatic and supportive... 

General contraindications include salicylate hypersensitivity unrealistic patient expectations active inflammation/dermatitis of the site to be peeled acute viral infection pregnancy isotretinoin therapy within 6 months of peeling or history of poor or delayed wound healing. Having peeled more than 1,000 patients with sahcyhc acid, the author has observed no cases of salicylate hypersensitivity from topical peeling. 

In general, there are few contraindications to salicylic acid chemical peeling. General contraindications include salicylate hypersensitivity or allergy unrealistic patient expectations active inflammation/ dermatitis or infection at the salicylic acid peeling site acute viral infection pregnancy and isotretinoin therapy within 3 to 6 months of the peeling procedure. 

Fludrocortisone is contraindicated in patients with hypersensitivity to fludrocortisone and those with systemic fungal infections. Fludrocortisone is used cautiously in patients with Addison s disease infection, and during pregnancy (Pregnancy Category C) and lactation. Fludrocortisone decreases the effects of the barbiturates, hydantoins, and rifampin. There is a decrease in serum levels of the salicylates when those agents are administered with fludrocortisone... 

The keratolytics are contraindicated in patients with known hypersensitivity to the drugs and for use on moles, birthmarks, or warts with hair growing from them, on genital or facial warts, on warts on mucous membranes, or on infected skin. Prolonged use of the keratolytics in infants or patients with diabetes or impaired circulation is contraindicated. Salicylic acid... 

In addition to salicylic and acetic acids, very small quantities of acetylsalicylanhy-dride (0.0012 to 0.024%) and acetylsalicylsalicylic acid (0.03 to 0.1%) have been found in aspirin preparations. The former has been determined by gas chromatography,1 0 TLC170 and spectrophotometry,171 the latter by gas chromatography. 14 0,1 a controversy is still ongoing (cf. 152) whether the occasionally observed hypersensitivity against aspirin is caused by these two impurities and whether the basis of the adverse reaction is immunological. 

Isoprinosine Indomethacin Quinidine Salicylates Delayed-type hypersensitivity increases T-lymphocytes Rash, urticaria, asthma, granulocytopenia Fever, anaphylaxis, asthma Rash, urticaria... 

SODiUM SALiCYLATE Less effective than an equal dose of aspirin in reducing pain or fever. Patients hypersensitive to aspirin may be able to tolerate sodium salicylate. Each gram contains 6.25 mEq sodium. 

Hypersensitivity to salicylates or nonsteroidal anti-inflammatory drugs (NSAIDs). Use extreme caution in patients with history of adverse reactions to salicylates. Cross-sensitivity may exist between aspirin and other NSAIDs that inhibit prostaglandin synthesis, and aspirin, and tartrazine. Aspirin cross-sensitivity does not appear to occur with sodium salicylate, salicylamide, or choline salicylate. Aspirin hypersensitivity is more prevalent in those with asthma, nasal polyposis, chronic urticaria. 

Hypersensitivity to salicylates or any of the components of balsalazide capsules or balsalazide metabolites. 

Intestinal or urinary obstruction porphyria, hypersensitivity to sulfasalazine, its metabolites, salicylates, or sulfonamides. 

Adverse effects. Nausea, anorexia, vomiting, skin rash, diarrhea, hypersensitivity reactions including to ordinary salicylates, rarely blood dyscrasias, pancreatitis, hepatitis, interstitial nephritis. 

Some patients exhibit hypersensitivity to aspirin in the form of salicylism, which is accompanied by ringing in the ears (tinnitus), vertigo, and bronchospasm (especially in asthmatics). The use of salicylate-containing preparations is not the only source of this drug. Those sensitive to salicylates should be aware of salicylates in a number of foods, such as curry powder, licorice, prunes, raisins, and paprika. 

The arylpropionic acid derivatives are useful for the treatment of rheumatoid arthritis and osteoarthritis, for reduction of mild to moderate pain and fever, and for pain associated with dysmenorrhea. Side effects of the drugs are similar to but less severe than those described for the salicylates. Those who are sensitive to salicylates also may be sensitive to and have adverse reactions when taking ibuprofen and related drugs. Acute hypersensitivity to ibuprofen has been reported in patients with lupus. The hypersensitivity reaction to sulindac can be fatal. The use of sulindac has also been linked to cases of acute pancreatitis. The use of dimethylsulfoxide (DMSO) topically in combination with sulindac has been reported to induce severe neuropathies. The concurrent use of ibuprofen with aspirin reduces the antiinflammatory effects of both drugs. Ibuprofen is contraindicated in patients with aspirin sensitivity leading to bronchiolar constriction and in patients with an-gioedema. As with all NSAIDs, renal and liver function should be normal for adequate clearance of the drugs. 

Sulfasalazine is contraindicated in individuals with hypersensitivity to salicylates, sulfonamides, sulfonylureas, and certain diuretics (furosemide, thiazides, and carbonic anhydrase inhibitors). Because it can cause kernicterus, sulfasalazine is contraindicated in infants and children under 2 years of age. Sulfasalazine passes into breast milk and is therefore contraindicated for nursing mothers. Similarly, pregnant women near term should not use this drug, although it appears to be the safest of the DMARDs during early pregnancy. 

Contraindications Severe renal impairment, hypersensitivity to magnesium salicylate or any component of the formulation... 

Contraindications Impaired circulation, hypersensitivity to salicylic acid or any of its... 

Contraindications Bleeding disorders, hypersensitivity to salicylates or NSAIDs... 

Enyedi, A. J., Yalpani, N., Silverman, P. and Raskin, I. (1992). Localization, conjugation, and function of salicylic-acid in tobacco during the hypersensitive reaction to tobacco mosaic-virus. Proceedings of the National Academy of Sciences, USA 89 2480-2484. 

---