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Acetylsalicylsalicylic acid

O-Acetylsalicylsalicylic acid [530-75-6] M 300.3, m 159". Crystd from dilute acetic acid. [Pg.92]

In addition to salicylic and acetic acids, very small quantities of acetylsalicylanhy-dride (0.0012 to 0.024%) and acetylsalicylsalicylic acid (0.03 to 0.1%) have been found in aspirin preparations. The former has been determined by gas chromatography,1 0 TLC170 and spectrophotometry,171 the latter by gas chromatography. 14 0,1 a controversy is still ongoing (cf. 152) whether the occasionally observed hypersensitivity against aspirin is caused by these two impurities and whether the basis of the adverse reaction is immunological. [Pg.30]

O-Acetylsalicylsalicylic acid [530-75-6] M 300.3, m 159 . Crystd from dilute acetic acid. iV-(4)-AcetylsulfaniIaniide [144-80-9] M 214.2, m 216 . Crystd from aqueous EtOH. [Pg.92]

Fig. 16. Formation of AT-salicyloyl amines by aminolysis of acetylsalicylic anhydride and acetylsalicylsalicylic acid... Fig. 16. Formation of AT-salicyloyl amines by aminolysis of acetylsalicylic anhydride and acetylsalicylsalicylic acid...
These results strongly suggest that the immunogenic effect of acetylsalicylic acid preparations as observed in experimental animals is due to acetylsalicylic anhydride and/or acetylsalicylsalicylic acid present as impurities in the preparations and not to the acetylsalicylic acid itself. By extrapolation of these findings to clinical acetylsalicylic acid allergy, it may appear that the impurities rather than the drug substance itself are responsible for the appearance of anti-salicyloyl antibodies in patients treated with acetylsalicylic acid. [Pg.62]

Ali SL (1976 a) Gas-chromatographic determination of traces of acetylsalicylic anhydride and acetylsalicylsalicylic acid in acetylsalicylic acid. Z Analyt Chem 278 365-366... [Pg.67]

Ali SL (1976 b) Application of gas-liquid chromatography and high-performance liquid chromatography to the analysis of trace amounts of salicylic acid, acetylsalicylic anhydride and acetylsalicylsalicylic acid in aspirin samples and aspirin formulations. J Chromatogr 126 651-663... [Pg.67]

Igarashi H, Koizumi K, Muranaka M (1978) Eliciting antigenicities of benzylpenicillin, ampicillin and carbenicillin preparations examined with the reagin-mediated passive cutaneous anaphylaxis system. Int Arch Allergy Appl Immunol 57 341-348 Jansson S-0, Andersson I (1977) Determination of salicylic acid, acetylsalicylic anhydride and acetylsalicylsalicylic acid in acetylsalicylic acid by high-performance liquid chromatography. Acta Pharm Suec 14 161-170... [Pg.70]

Reactive chemical impurities as byproducts of synthesis acetylsalicylsalicylic acid and acetylsalicylic anhydride in aspirin... [Pg.227]

Simultaneous acetylsalic lic add anhydride, acetylsalicylsalicylic acid, salicylic add, exdpients... [Pg.131]

Bundgaard, H. (1974) Acetylsalicylsalicylic acid a potentially immunogenic impurity in acetylsalicylic acid. J. Pharm. Pharmacol, 26, 18. [Pg.79]

See other pages where Acetylsalicylsalicylic acid is mentioned: [Pg.28]    [Pg.291]    [Pg.28]    [Pg.274]    [Pg.226]    [Pg.61]    [Pg.61]    [Pg.68]    [Pg.81]    [Pg.228]    [Pg.261]    [Pg.261]    [Pg.377]   
See also in sourсe #XX -- [ Pg.61 , Pg.81 , Pg.227 , Pg.228 , Pg.287 ]



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