Ruthenium tetraoxide compound

Epimerization of 50 at C-3 furnished carba-a-DL-allopyranose (60). Stepwise, 0-isopropylidenation of 50 with 2,2-dimethoxypropane afforded compound 56. Ruthenium tetraoxide oxidation of 56 gave the 3-oxo derivative 57, and catalytic hydrogenation over Raney nickel converted 57 into the 3-epimer 58 exclusively. Hydrolysis of 58, and acetylation, provided the pentaacetate 59, which was converted into 60 on hydrolysis. ... 

In contrast to those results, no useful discrimination between endo and exo hydroxyl groups could be found when employing ruthenium tetraoxide as an oxidant.213 Compounds 4,3, and 5 each affords the diketone 9 exclusively this was isolated as the bis(2,4-dinitrophenylhydrazone). 

Oxidation of organic compounds by ruthenium tetraoxide has been reviewed. The oxidation of various types of organic compounds such as alkanes, alkenes, allenes, aromatic rings, alcohols, amines, and sulfides has been discussed The cyclic oxoruthe-nium(VI) diesters that are formed in the initial step of the oxidation of alkenes are considered to be intermediates in the formation of 1,2-diols.70 The development of new and selective oxidative transformations under ruthenium tetroxide catalysis during the past 10 years has been reviewed. The state of research in this field is summarized and a systematic overview of the reactivity and the reaction mode of ruthenium tetroxide is given.71... 

The oxidation catalyst is believed to be ruthenium tetraoxide based on work by Engle,149 who showed that alkenes could be cleaved with stoichiometric amounts of ruthenium tetraoxide. Suitable solvents for the Ru/peracid systems are water and hexane, the alkene (if liquid) and aromatic compounds. Complex-ing solvents like dimethylformamide, acetonitrile and ethers, and the addition of nitrogen-complexing agents decrease the catalytic system s activity. It has also been found that the system has to be carefully buffered otherwise the yield of the resulting carboxylic acid drops drastically.150 The influence of various ruthenium compounds has also been studied, and generally most simple and complex ruthenium salts are active. The two exceptions are Ru-red and Ru-metal, which are both inferior to the others. Ruthenium to olefin molar ratios as low as 1/20000 will afford excellent cleavage yields (> 70%). vic-Diols are also... 

Carlsen PHJ, Katsuki T, Martin VS, Sharpless KB (1981) A Greatly Improved Procedure for Ruthenium Tetraoxide Catalyzed Oxidations of Organic Compounds. J Org Chem 46 3936... 

BENSULFOID (7704-34-9) Combustible solid (flash point 405°F/207°C). Finely divided dry materia forms explosive mixture with air. The vapor reacts violently with lithium carbide. Reacts violently with many substances, including strong oxidizers, aluminum powders, boron, bromine pentafluoride, bromine trifluoride, calcium hypochlorite, carbides, cesium, chlorates, chlorine dioxide, chlorine trifluoride, chromic acid, chromyl chloride, dichlorine oxide, diethylzinc, fluorine, halogen compounds, hexalithium disilicide, lampblack, lead chlorite, lead dioxide, lithium, powdered nickel, nickel catalysis, red phosphorus, phosphorus trioxide, potassium, potassium chlorite, potassium iodate, potassium peroxoferrate, rubidium acetylide, ruthenium tetraoxide, sodium, sodium chlorite, sodium peroxide, tin, uranium, zinc, zinc(II) nitrate, hexahydrate. Forms heat-, friction-, impact-, and shock-sensitive explosive or pyrophoric mixtures with ammonia, ammonium nitrate, barium bromate, bromates, calcium carbide, charcoal, hydrocarbons, iodates, iodine pentafluoride, iodine penloxide, iron, lead chromate, mercurous oxide, mercury nitrate, mercury oxide, nitryl fluoride, nitrogen dioxide, inorganic perchlorates, potassium bromate, potassium nitride, potassium perchlorate, silver nitrate, sodium hydride, sulfur dichloride. Incompatible with barium carbide, calcium, calcium carbide, calcium phosphide, chromates, chromic acid, chromic... 

The chemistry of ruthenium and osmium bears little resemblance to that of iron except in compounds such as sulfideror phosphides, and in complexes with ligands such as CO, PR3, or A5-C5H5. The higher oxidation states, VI and VIII, are much more readily obtained than for iron and there is an extensive and important chemistry of the tetraoxides, M04, oxohalides and oxo anions. There are analogies between the chemistries of Ru, Os and Re especially in oxo, nitrogen and nitrido compounds. 

Ruthenium and osmium tetraoxides and oxo anions provide some of the more unusual and useful features of the chemistry. The major compounds or ions are shown in Table 26-F-2. 

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