Ruthenium acetate

Pyrido[],2-a]pyrimidine-3,7-dicarboxylate 396 was also obtained in the reaction of diazo compound 395 and methyl vinyl ketone in boiling benzene in the presence of a catalytic amount of ruthenium acetate. 

The drug candidate OPC-51803 is the first nonpeptide vasopressin V2-receptor-selective agonist that is in phase II clinical trials and the best chiral reduction to the intermediate acid (E) was with ruthenium acetate-[(5)-H8-BlNAP] that gave a 77 % ee (Figure 1.10). An improved catalyst system will be needed for large scale production. 

The binding of the trinuclear J,3-oxo-ruthenium acetate clusters to the metaflo-porphyrin ring can also improve the activity of the metalloporphyrin catalyst, by incorporating new electron-withdrawing/donor-, and/or ET properties. Because of... 

S Ruthenium acetate is available from Johnson Matthey, London. 

Triethylamine neutralizes acetic acid present in the crude acetate salt of ruthenium and acetic acid formed during the reductive hydrolysis of the ruthenium. Acetic acid slowly converts Ru3(CO)i2 into [Ru(C0)s(02CCH3)l2, consequently lowering the yield of Rus-(CO)l2. 

Asymmetric reduction with very high enantioselectivity has also been achieved with achiral reducing agents and optically active catalysts. Two approaches are represented by (1) homogeneous catalytic hydrogenation with the catalyst 2,2 -bis(diphenylphosphino)-1,1 -binaphthyl-ruthenium acetate, BINAP Ru(OAc)2, which reduces... 

Recent literature describes the synthesis of vinyl esters in the presence of platinum metal complexes. Complexes which have proven particularly suitable in this context are those of ruthenium (eq. (15)), such as, for example, cyclooc-tadienylruthenium halides [36], ruthenium carbonyl complexes, and ruthenium acetate complexes [37]. A characteristic feature of these is their high selectivity with regard to acetylene, so that the production of acetylene polymers is reduced. 

BASIC RUTHENIUM ACETATE AND MIXED VALENCE DERIVATIVES... 

Basic Ruthenium Acetate and Mixed Valence Derivatives 157... 

Figure 1. Structure of basic ruthenium acetate framework.

T riphenylphosphine—Diethyl azodi-carboxylate, 280, 645 Triphenylphosphine dibiomide, 645-646 Triphenylphosphine dichloride, 646-647 Triphenylphosphine dihaiides, 647-648 Triphenylphosphine diiodide, 648 Triphenylphosphine ditriflate, 648 Triphenylphosphite methiodide, 649 Triphenyl phosphite ozonide, 435 Triphenyl(prop-2-ynyl)phosphonium bromide, 494 Triphenylsilanol, 655, 656 Triphenylstannane, 649 Triphenyltin hydride, 649 Triphenylvinylsilane, 637 Triphosphopyridine nucleotide, 36-37 Tri- -propyl orthovanadate, 655 Tris-annelation, 410 Ttis(aquo)hexa-fi-acetato-p,-oxotri-ruthenium acetate, 425-426,650 Tris(dimethoxyboryl)methane, 328, 329 Tris(dimethylamino)borane, 554 Trishomocubanone, 108 Tris(neomenthyldiphenylphosphine)-chlororhodium, 416... 

Araki, K., S. Dovidauskas, H. Winnischofer, A.D.P. Alexiou, and H.E. Toma (2001). A new highly efficient tetra-electronic catalyst based on a cobalt porphyrin bound to four mu3-oxo-ruthenium acetate clusters. J. Electroanal. Chem. 498, 152-160. 

C66H63O13P3RU3, Ruthenium acetate tris(triphenylphosphine) adduct, 38B, 887... 

In a previous review [4], we focused on the electrocatalytic properties of well-characterized supermolecules, generated by the coordination of transition metal complexes, such as ruthenium polypyridines and triangular ruthenium acetate... 

Fig. 11 Scheme showing the photoinduced electron transfer from the porphyrin to a trigonal ruthenium acetate cluster complex dimer... 

A, B, and C were isolated and their structure confirmed by X-ray crystallographic analysis of their single crystals. First, the in situ generated ruthenium acetate catalyst reacts with isoquinolone to form the five-membered ruthenacycle A by an acetate-assisted deprotonation mechanism. Then, the alkyne insertion into the Ru-C bond affords a seven-membered ruthenacycle intermediate B. After the reductive elimination from B forming the C-N bond, a Ru(0) intermediate C was generated. Finally, the desired product was obtained from the decoordination of a Ru(0) species which regenerated the active Ru(OAc)2(p-cymene) initial complex on oxidation with copper acetate (Scheme 19) [185]. 

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