Risk Profiles

Figures 12 and 13 illustrate two of the more commonly used methods for displaying societal risk results (1) an F-N curve and (2) a risk profile. The F-N curve plots the cumulative frequencies of events causing N or more impacts, with the number of impacts (N) shown on the horizontal axis. With the F-N curve you can easily see the expected frequency of accidents that could harm greater than a specified number of people. F-N curve plots are almost always presented on logarithmic scales because of...

While the F-N curve is a cumulative illustration, the risk profile shows the expected frequency of accidents of a particular category or level of consequence. The diagonal line is a line of constant risk defined such that the product of expected frequency and consequence is a constant at each point along the line. " As the consequences of accidents go up, the expected frequency should go down in order for the risk to remain constant. As the example illustrates, if a portion of the histogram sticks its head up above the line (i.e., a particular type of accident contributes more than its fair share of the risk), then that risk is inconsistent with the risk presented by other accident types. (Note There is no requirement that you use a line of constant risk other more appropriate risk criteria for your application can be easily defined and displayed on the graph.)... 

The F-N curve, the risk profile, and the risk contour are the three most commonly used methods of graphically presenting risk results. Normally, you will elect to use more than one of these methods when evaluating risk estimates for decision making. 

The main screen displays a 90 days history of the plant s risk profile in terms of CDF, release, or boiling. Movement of a slider positions the time interval that is desired. U has iwo... 

It may be more appropriate for the decision-making team to express preferences after the need for trade-off between the different compounds found has become apparent via the search results. Visualization and quantitative analysis techniques can then be used to reveal the trade-offs in the problem, facilitating the choice of a single compound, or a candidate and one or more backups that have different risk profiles. 

Once the preliminary analysis is completed, it is necessary to integrate it into a more complete analysis in which it will play an essential part. The results of this analysis are formalised by creating a risk profile or risk map. 

Risk Profile 10-Year Risk for CHD Need for Framingham Calculation... 

De Caterina R., Sicari R Bernini W et al. Benefit/risk profile of combined antiplatelet therapy with ticopidine and aspirin. Thromb Haemost 1991 65,504-10. 

Any analysis of risk should recognize these distinctions in all of their essential features. A typical approach to acute risk separates the stochastic nature of discrete causal events from the deterministic consequences which are treated using engineering methods such as mathematical models. Another tool if risk analysis is a risk profile that graphs the probability of occurrence versus the severity of the consequences (e.g., probability, of a fish dying or probability of a person contracting liver cancer either as a result of exposure to a specified environmental contaminant). In a way, this profile shows the functional relationship between the probabilistic and the deterministic parts of the problem by showing probability versus consequences. 

Scientific Committee on Food (SCF), European Commission (2002), Risk Profile on the Microbiological Contamination of Fruits and Vegetables Eaten Raw, Report. 

Healthy lifestyle is mandatory for all postmenopausal women together with adequate correction of detected risk factors. That is why this intervention is in the center of the diagram and concerns 100% of the women in this period. Then a decision must be made as to whether the woman s risk profile calls for any intervention beyond lifestyle improvement. The use of surrogate markers or risk scores can be useful in evaluating individual patients. 

Women with osteoporosis, either densitometric or established, and some cases of osteopenia with increased fracture risk require pharmacological intervention. Any intervention for osteoporosis is expected to be long lasting. Thus it is difficult to expect that interventions in young postmenopausal women could be maintained for the remainder of one s fife. The susceptibility to side effects changes either with the process of aging or the repeated use of a given product. Sequential treatment schedules, adapted to the risk profile of each period, would probably be more suitable. 

VII. Although politicians use risk profiles as being discrete transitions, these profiles actually represent a continuous phenomenon with a high degree of uncertainty. 

The chlorinated chemicals assessed do not have the same risk profile. For the more volatile chemicals the safety margins between the actual exposure and the level at which no effect on the environment would be expected is quite high. For more persistent chemicals there is a need to look to the environmental compartment where they can be accumulated (mainly in sediments and biota). For some of these chemicals the safety margin is quite low and in worst-case situations serious effects may occur. For the very persistent, bioaccumulative and toxic chemicals (like dioxins, PCBs and DDT), acceptable environmental concentrations are so low and difficult to control that the industry is committed to reducing as far as possible releases to the environment through application of Best Available Techniques (BAT), mainly with respect to dioxins. For other chemicals (PCBs, DDT), production has already been halted for some years. 

Mataragas, M., Skandamis, P. N., and Drosinos, E. H. (2008). Risk profiles of pork and poultry meat and risk ratings of various pathogen/product combinations. Inf. /. Food Microbiol. 126,1-12. 

Other terms used to describe this phase of the risk assessment process include problem dehnition, problem characterization, risk profiling (EC 2000), and scoping phase. ... 

Patients with high coronary-risk profile... 

Anderson KM, Odell PM, Wilson PW, Knnnel WB. Cardiovascnlar disease risk profiles. Am Heart J 1991 121 293-8. 

Young, J.M., Shytle, R.D., Sanberg, P.R., and George, T.P. (2001) Mecamylamine New therapeutic uses and toxicity/risk profile. Clin Ther 23 532-565. 

CONCEIVED and PRESENTED customized analytics designed to assess Asset Liability Management risk profiles, which led to increased sales of securities to banks, credit unions, and municipalities. 

All the previous information makes sense on a rational analysis basis, but as we know, for every buyer in the stock market, there is a seller. These individuals and institutions have different risk profiles—they have different expectations of the future. 

At the time of this writing, celecoxib (Celebrex) is the only COX-2 selective drug that is still available. It will be interesting to see if new COX-2 drugs can be developed that have an acceptable cardiovascular risk profile. Likewise, efforts continue to clearly identify patients who should not take these drugs because of an increased risk for heart attack or ischemic stroke. 

Thus, the risk analysis must be well prepared, meaning that the scope of the analysis must be clearly defined data must be available and evaluated, to define the safe process conditions and the critical limits. Then, and only then, the systematic search for process deviations from the safe conditions can be started. The identified deviations lead to the definition of scenarios, which can be assessed in terms of severity and probability of occurrence. This work can advantageously be summarized in a risk profile, enhancing the major risks that are beyond the accepted limits. For these risks, reduction measures can then be defined. The residual risk, that is, the risk remaining after implementation of the measures, can be assessed as before and documented in a residual risk profile showing the progress of the analysis and the risk improvement. These steps are reviewed in the next sections. 

The criteria mentioned in Tables 1.4 and 1.5 are given as an example of a possible practice, but as a part of the company s risk policy, they must be defined for each company with respect to its actual situation. Severity and probability of occurrence of an event form the two coordinates of the risk profile. 

At this stage, a second risk profile can be constructed, in a similar way to that shown in Section 1.3.1.6. This allows the identification of the risks that are now... 

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