Technique of quantitative analysis

The technique of quantitative analysis is broadly based on the following three major heads, namely ... 

Part—I has three chapters that exclusively deal with General Aspects of pharmaceutical analysis. Chapter 1 focuses on the pharmaceutical chemicals and their respective purity and management. Critical information with regard to description of the finished product, sampling procedures, bioavailability, identification tests, physical constants and miscellaneous characteristics, such as ash values, loss on drying, clarity and color of solution, specific tests, limit tests of metallic and non-metallic impurities, limits of moisture content, volatile and non-volatile matter and lastly residue on ignition have also been dealt with. Each section provides adequate procedural details supported by ample typical examples from the Official Compendia. Chapter 2 embraces the theory and technique of quantitative analysis with specific emphasis on volumetric analysis, volumetric apparatus, their specifications, standardization and utility. It also includes biomedical analytical chemistry, colorimetric assays, theory and assay of biochemicals, such as urea, bilirubin, cholesterol and enzymatic assays, such as alkaline phosphatase, lactate dehydrogenase, salient features of radioimmunoassay and automated methods of chemical analysis. Chapter 3 provides special emphasis on errors in pharmaceutical analysis and their statistical validation. The first aspect is related to errors in pharmaceutical analysis and embodies classification of errors, accuracy, precision and makes... 

NIR spectroscopy became much more useful when the principle of multiple-wavelength spectroscopy was combined with the deconvolution methods of factor and principal component analysis. In typical applications, partial least squares regression is used to model the relation between composition and the NIR spectra of an appropriately chosen series of calibration samples, and an optimal model is ultimately chosen by a procedure of cross-testing. The performance of the optimal model is then evaluated using the normal analytical performance parameters of accuracy, precision, and linearity. Since its inception, NIR spectroscopy has been viewed primarily as a technique of quantitative analysis and has found major use in the determination of water in many pharmaceutical materials. 

This text is designed for college students majoring in chemistry and fields related to chemistry. It deals with the principles and techniques of quantitative analysis, that is, how to determine how much of a specific substance is contained in a sample. You will learn how to design an analytical method, based on what information is needed, how to obtain a laboratory sample that is representative of the whole, how to prepare it for analysis, what measurement tools are available, and the statistical significance of the analysis. Chapters 24-26 illustrate applications of techniques you have learned to the fields of clinical chemistry, genomics and pro-teomics, and environmental sampling and analysis. 

The techniques of quantitative analysis were advanced significantly by the German, Martin Klaproth (1743-1817). He devoted much attention to sources of error and their elimination. He published all his experimental data, such as weights of... 

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